ID G5JSE5_STRCG Unreviewed; 932 AA.
AC G5JSE5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=STRCR_2144 {ECO:0000313|EMBL:EHI75341.1};
OS Streptococcus criceti HS-6.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=873449 {ECO:0000313|EMBL:EHI75341.1, ECO:0000313|Proteomes:UP000004322};
RN [1] {ECO:0000313|EMBL:EHI75341.1, ECO:0000313|Proteomes:UP000004322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS-6 {ECO:0000313|EMBL:EHI75341.1,
RC ECO:0000313|Proteomes:UP000004322};
RA Stanhope M.J., Durkin A.S., Hostetler J., Kim M., Radune D., Singh I.,
RA Town C.D.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHI75341.1}.
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DR EMBL; AEUV02000002; EHI75341.1; -; Genomic_DNA.
DR AlphaFoldDB; G5JSE5; -.
DR STRING; 873449.STRCR_2144; -.
DR eggNOG; COG0827; Bacteria.
DR eggNOG; COG1002; Bacteria.
DR Proteomes; UP000004322; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 497..609
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
FT DOMAIN 720..862
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 932 AA; 106607 MW; AC27829D2337C4EB CRC64;
MDERFKVDLF RFAIADDEQF INKTRVLRLN FWKRIKEDTK CRKIINKIFF KEPSYTDESS
ERYGDVISAV LDTLVLRYIL VRILEGRFGY ENDLAKKSVA KIGLGTSLSI DQLLESKAHF
DQQQKDELFA SKKKAAQLSL FDLLPDEIDI QAVSEIQDEQ SAYMEEMYGG DLYVSDIAKA
ATQIEGTLSE AEYALIWNVT SSTDLDFDLD DVTPGTIGEQ YEQTLQMKLV QDEAGNWVYS
KDNEKQRSQG SFYTSAQITD YIIEQTLGKR LSEIKHKLID KESSENQKIK ILRDTLNLKM
ADISSGGGTF LAGAVRKLGD WYTELEKVED IKELLPKISN FKSAIEFQKY AVNHMIYGVD
LDLKALIVSS FALTLESLGD TQGKLPELIG RTLIHQNSLV SLVPESLKLE WFAAYKDDIA
KLYTEKKKWL SKKSNDFFEV KAKLQQIFAD MASEHLRSKK YAKESLENVF VDKHMEVLEF
NLPEVFFDKN GNYSGGFDII FGNPPYIQLQ GNFSDIEQGL YSNLGEFESF QKRGDIYGLF
FERGVHLLKP NGLLGFITSN KYLRSGYGKT LRNFFLERTN PLLLVNLGSG MFGGATVDTS
ILVLEKSTNQ NKLKAIDLSK RSNNPKERLE NMSDYIMQNK ASISYVRNES WIILSSIEQS
IKSKIESIGT PLKNWEISIN YGIKTGFNEA FIINADKRNE ILENCQTDDE RQRTAELIRP
ILRGRDIKRY SYMMAKLYVI AAYKGINEII TKKYPAIYSY LSQYENQLRQ RGQCEGTPDK
PGSKQHHWTE LDNNISLEKL DDFSKQKIVY REISNNTDAC IVEPNIVTNN KCYIITGKHL
IYLLTILNST IFNKFILSRA NSTGGKGPDF MKNISIPIPT DDIEVLLENL YNKRISCGNG
DNIEKIDKNT NNIVYSIFEL SSTEIEYIET VN
//
