ID G5K9F4_9STRE Unreviewed; 453 AA.
AC G5K9F4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=23S rRNA (Uracil-5-)-methyltransferase RumA {ECO:0000313|EMBL:EHI64502.1};
DE EC=2.1.1.- {ECO:0000313|EMBL:EHI64502.1};
GN Name=rumA_1 {ECO:0000313|EMBL:EHI64502.1};
GN ORFNames=STRPS_0373 {ECO:0000313|EMBL:EHI64502.1};
OS Streptococcus pseudoporcinus LQ 940-04.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=875093 {ECO:0000313|EMBL:EHI64502.1, ECO:0000313|Proteomes:UP000003217};
RN [1] {ECO:0000313|EMBL:EHI64502.1, ECO:0000313|Proteomes:UP000003217}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LQ940-04 {ECO:0000313|Proteomes:UP000003217};
RX PubMed=24625962; DOI=10.1093/gbe/evu048;
RA Richards V.P., Palmer S.R., Pavinski Bitar P.D., Qin X., Weinstock G.M.,
RA Highlander S.K., Town C.D., Burne R.A., Stanhope M.J.;
RT "Phylogenomics and the dynamic genome evolution of the genus
RT Streptococcus.";
RL Genome Biol. Evol. 6:741-753(2014).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01024}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHI64502.1}.
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DR EMBL; AEUY02000005; EHI64502.1; -; Genomic_DNA.
DR RefSeq; WP_007894741.1; NZ_AEUY02000005.1.
DR AlphaFoldDB; G5K9F4; -.
DR STRING; 361101.GCA_900102825_01578; -.
DR GeneID; 58554932; -.
DR OrthoDB; 9804590at2; -.
DR Proteomes; UP000003217; Unassembled WGS sequence.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001510; P:RNA methylation; IEA:GOC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.40.50.1070; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR030390; MeTrfase_TrmA_AS.
DR InterPro; IPR030391; MeTrfase_TrmA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002792; TRAM_dom.
DR InterPro; IPR010280; U5_MeTrfase_fam.
DR NCBIfam; TIGR00479; rumA; 1.
DR PANTHER; PTHR11061:SF48; 23S RRNA (URACIL(747)-C(5))-METHYLTRANSFERASE RLMC; 1.
DR PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1.
DR Pfam; PF01938; TRAM; 1.
DR Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR PROSITE; PS50926; TRAM; 1.
DR PROSITE; PS01230; TRMA_1; 1.
DR PROSITE; PS01231; TRMA_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01024};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01024};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01024}.
FT DOMAIN 1..59
FT /note="TRAM"
FT /evidence="ECO:0000259|PROSITE:PS50926"
FT ACT_SITE 408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10015"
FT ACT_SITE 408
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 283
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 312
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 333
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 381
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
SQ SEQUENCE 453 AA; 51191 MW; 7720148DD9FA3583 CRC64;
MLKKNDIVEV VIEDLSHQGS GIAKVDGFVF FVENALPTER ITMRVLKLNK KIGFGKVEDY
LEKSPHRNEN LDLAYLRTGI ADFGHLAYEE QLLFKAKQVK DNLYKTAGIK AVELLPTIGM
EQPYAYRNKA QIPVRRVNGQ LETGFFRKNS HDLLPISDFY IQDKEIDKLI LFVRNLLRRF
QVSPYNEADQ SGLIKNLVVR RGHYSGQMML VFVTSRPKVF RVEQMVQLIT EAFPQVVSIM
QNVNDQNSNA IFSKDFKVLY GQDYITDSIL GNDYMISAQS FYQVNTVMAE KLYQTAIDFS
DLSADDVVID AYSGIGTIGL SFAKKVKKVY GVEVIEAAVK DARKNAERNG IRNAEFLVGS
AEAAMEKWSK EGIKPSVILV DPPRKGLTES FIKASAAMAP KKITYVSCNP ATMARDIKHY
QELGYNLIKA QPVDLFPHTH HVECIALIQR VKS
//