ID G5NH17_SALET Unreviewed; 399 AA.
AC G5NH17;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Multidrug resistance protein A {ECO:0000313|EMBL:EHC53538.1};
GN ORFNames=LTSEINV_4202 {ECO:0000313|EMBL:EHC53538.1};
OS Salmonella enterica subsp. enterica serovar Inverness str. R8-3668.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=913075 {ECO:0000313|EMBL:EHC53538.1, ECO:0000313|Proteomes:UP000003532};
RN [1] {ECO:0000313|EMBL:EHC53538.1, ECO:0000313|Proteomes:UP000003532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R8-3668 {ECO:0000313|EMBL:EHC53538.1,
RC ECO:0000313|Proteomes:UP000003532};
RX PubMed=21859443; DOI=10.1186/1471-2164-12-425;
RA den Bakker H.C., Moreno Switt A.I., Govoni G., Cummings C.A., Ranieri M.L.,
RA Degoricija L., Hoelzer K., Rodriguez-Rivera L.D., Brown S., Bolchacova E.,
RA Furtado M.R., Wiedmann M.;
RT "Genome sequencing reveals diversification of virulence factor content and
RT possible host adaptation in distinct subpopulations of Salmonella
RT enterica.";
RL BMC Genomics 12:425-425(2011).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHC53538.1}.
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DR EMBL; AFCO01001382; EHC53538.1; -; Genomic_DNA.
DR AlphaFoldDB; G5NH17; -.
DR PATRIC; fig|913075.3.peg.3258; -.
DR BioCyc; SENT913075:G120P-3463-MONOMER; -.
DR Proteomes; UP000003532; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR005694; MFP_proteobact.
DR NCBIfam; TIGR00998; 8a0101; 1.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..355
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 178..298
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 131..189
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 399 AA; 43615 MW; BD6458534FC43158 CRC64;
MNNKIVENNM SVNAEIQTPQ QPAKKKGKRK TALLLLTLLF VIIAVAYGIY WFLVLRHIEE
TDDAYVAGNQ VQIMAQVSGS VTKVWADNTD FVKEGDVLVT LDQTDAKQAF EKAKTALASS
VRQTHQLMIN SKQLQANIDV QKTALAQAQS DLNRRVPLGN ANLIGREELQ HARDAVASAQ
AQLDVAIQQY NANQAMILNS KLEDQPAVQQ AATEVRNAWL ALERTRIVSP MTGYVSRRAV
QPGAQISPTT PLMAVVPATD LWVDANFKET QLANMRIGQP VTIITDIYGD DVKYTGKVVG
LDMGTGSAFS LLPAQNATGN WIKVVQRLPV RVELDARQLE QHPLRIGLST LVTVDTANRD
GQVLASQVRT TPVAESNARE INLAPVNKLI DDIVQANAG
//
