ID G5Q3C5_SALMO Unreviewed; 461 AA.
AC G5Q3C5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Type 3 secretion system secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Short=T3SS secretin {ECO:0000256|HAMAP-Rule:MF_02219};
GN Name=sctC {ECO:0000256|HAMAP-Rule:MF_02219};
GN ORFNames=LTSEMON_2485 {ECO:0000313|EMBL:EHC78860.1};
OS Salmonella enterica subsp. enterica serovar Montevideo str. S5-403.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=913242 {ECO:0000313|EMBL:EHC78860.1, ECO:0000313|Proteomes:UP000003221};
RN [1] {ECO:0000313|EMBL:EHC78860.1, ECO:0000313|Proteomes:UP000003221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S5-403 {ECO:0000313|EMBL:EHC78860.1,
RC ECO:0000313|Proteomes:UP000003221};
RX PubMed=21859443; DOI=10.1186/1471-2164-12-425;
RA den Bakker H.C., Moreno Switt A.I., Govoni G., Cummings C.A., Ranieri M.L.,
RA Degoricija L., Hoelzer K., Rodriguez-Rivera L.D., Brown S., Bolchacova E.,
RA Furtado M.R., Wiedmann M.;
RT "Genome sequencing reveals diversification of virulence factor content and
RT possible host adaptation in distinct subpopulations of Salmonella
RT enterica.";
RL BMC Genomics 12:425-425(2011).
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC with an apparent central pore in the outer membrane.
CC {ECO:0000256|HAMAP-Rule:MF_02219}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle. This subunit is part of the
CC base, which anchors the injectisome in the bacterial cell envelope.
CC Forms a stable homooligomeric complex. {ECO:0000256|HAMAP-
CC Rule:MF_02219}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004442, ECO:0000256|HAMAP-Rule:MF_02219,
CC ECO:0000256|RuleBase:RU004004}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC subfamily. {ECO:0000256|ARBA:ARBA00007032, ECO:0000256|HAMAP-
CC Rule:MF_02219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHC78860.1}.
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DR EMBL; AFCS01000590; EHC78860.1; -; Genomic_DNA.
DR AlphaFoldDB; G5Q3C5; -.
DR PATRIC; fig|913242.3.peg.2166; -.
DR Proteomes; UP000003221; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.120; -; 2.
DR Gene3D; 3.55.50.30; -; 1.
DR HAMAP; MF_02219; Type_III_secretin; 1.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR004846; T2SS/T3SS_dom.
DR InterPro; IPR004845; T2SS_GspD_CS.
DR InterPro; IPR003522; T3SS_OM_pore_YscC.
DR NCBIfam; TIGR02516; type_III_yscC; 1.
DR PANTHER; PTHR30332; PROBABLE GENERAL SECRETION PATHWAY PROTEIN D; 1.
DR PANTHER; PTHR30332:SF4; TYPE 3 SECRETION SYSTEM SECRETIN; 1.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 1.
DR PRINTS; PR01337; TYPE3OMGPROT.
DR PROSITE; PS00875; T2SP_D; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|HAMAP-Rule:MF_02219};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02219};
KW Protein transport {ECO:0000256|HAMAP-Rule:MF_02219};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_02219};
KW Translocation {ECO:0000256|ARBA:ARBA00023010, ECO:0000256|HAMAP-
KW Rule:MF_02219};
KW Transport {ECO:0000256|HAMAP-Rule:MF_02219, ECO:0000256|RuleBase:RU004004}.
FT DOMAIN 142..231
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 295..454
FT /note="Type II/III secretion system secretin-like"
FT /evidence="ECO:0000259|Pfam:PF00263"
SQ SEQUENCE 461 AA; 49835 MW; ED3D2F6F324F6178 CRC64;
MPLAEVLHLL SENYDTAITI SPLITATFSG KIPPGPPVDI LNNLAAQYDL LTWFDGSMLY
VYPASLLKHQ VITFNILSTG RFIHYLRSQN ILSSPGCEVK EITGTSAVEV SGVPSCLTRI
SQLASVLDNA LIKRKDSAVS VSIYTLKYAT AMDTQYQYRD QSVVVPGVVS VLREMSKTSV
PASSTNNGSP ATQALPMFAA DPRQNAVIVR DYAANMAGYR KLITELDQRQ QMIEISVKII
DVNAGDINQL GIDWGTAVSL GGKKIAFNTG LNDGGASGFS TVISDTSNFM VRLNALEKSS
QAYVLSQPSV VTLNNIQAVL DKNITFYTKL QGEKVAKLES ITTGSLLRVT PRLLNDNGTQ
KIMLNLNIQD GQQSDTQSET DPLPEVQNSE IASQATLLAG QSLLLGGFKQ GKQIHSQNKI
PLLGDIPVVG HLFRNDTTQV HSVIRLFLIK ASVVNNGISH G
//
