ID G5QX61_SALSE Unreviewed; 522 AA.
AC G5QX61;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=LTSESEN_1349 {ECO:0000313|EMBL:EHC91946.1};
OS Salmonella enterica subsp. enterica serovar Senftenberg str. A4-543.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=913082 {ECO:0000313|EMBL:EHC91946.1, ECO:0000313|Proteomes:UP000005065};
RN [1] {ECO:0000313|EMBL:EHC91946.1, ECO:0000313|Proteomes:UP000005065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A4-543 {ECO:0000313|EMBL:EHC91946.1,
RC ECO:0000313|Proteomes:UP000005065};
RX PubMed=21859443; DOI=10.1186/1471-2164-12-425;
RA den Bakker H.C., Moreno Switt A.I., Govoni G., Cummings C.A., Ranieri M.L.,
RA Degoricija L., Hoelzer K., Rodriguez-Rivera L.D., Brown S., Bolchacova E.,
RA Furtado M.R., Wiedmann M.;
RT "Genome sequencing reveals diversification of virulence factor content and
RT possible host adaptation in distinct subpopulations of Salmonella
RT enterica.";
RL BMC Genomics 12:425-425(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
CC Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the LRR-containing bacterial E3 ligase family.
CC {ECO:0000256|ARBA:ARBA00009868}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHC91946.1}.
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DR EMBL; AFCU01000449; EHC91946.1; -; Genomic_DNA.
DR AlphaFoldDB; G5QX61; -.
DR PATRIC; fig|913082.3.peg.1042; -.
DR BioCyc; SENT913082:G120J-2788-MONOMER; -.
DR Proteomes; UP000005065; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR Gene3D; 1.20.58.90; -; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.20.58.360; Shigella T3SS effector IpaH defines; 1.
DR Gene3D; 1.20.1270.130; Shigella T3SS effector IpaH domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029487; NEL_dom.
DR PANTHER; PTHR47114; -; 1.
DR PANTHER; PTHR47114:SF2; OLIGODENDROCYTE-MYELIN GLYCOPROTEIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF14496; NEL; 1.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 227..435
FT /note="NEL"
FT /evidence="ECO:0000259|Pfam:PF14496"
SQ SEQUENCE 522 AA; 59751 MW; 0AAA46C046B46D04 CRC64;
MELSINRITE LPERLPSALQ SLDLFHNKIS SLPENLPEEL RYLSVYDNRI RTLPEHLPSG
ITHLNVQSNS LTALPETLPP GLKNLEAGEN ALTSLPASLP PELQFLDVSK NQITVLPETL
PPTITTLDVS RNALSNLPEN LPAALQIMQA SRNRLVRLPE SLPRFRGEGP RPTRIIVEHN
PFSERTIQNM QRLMSSAGYQ GPEVFFAMGD FSIVRVTRPL HQAVQGWLTN LEEEDVNQWR
AFETEVNAAA FSMFLDRLSD TQNTRHPDFK EQVSAWLMRL ADDSTLRETA FFIAMDATIS
CEDRVTLAYH QMQEATLVHD AERGAFDSHL AELIMAGREI FRLEQIESLA REKVKRLFFI
DEVEVYLGFQ NQLRESLSLT TMTQDMRFYN VSGITESDLD DAEIRIKIAE NRDFHKWFAL
WGPWHKVLER IAPEEWREMM DKRAECIETD EYQSRVNAEL EALRIADDSD AERAIGKKIM
EEINQSLCTE LMENILLKKE VSSLPRGSPP SCLSSLMSAY WR
//
