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Database: UniProt
Entry: G6A189_9PROT
LinkDB: G6A189_9PROT
Original site: G6A189_9PROT 
ID   G6A189_9PROT            Unreviewed;       502 AA.
AC   G6A189;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   05-JUL-2017, entry version 39.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HIMB100_00020580 {ECO:0000313|EMBL:EHI48474.1};
OS   SAR116 cluster alpha proteobacterium HIMB100.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; SAR116 cluster.
OX   NCBI_TaxID=909943 {ECO:0000313|EMBL:EHI48474.1, ECO:0000313|Proteomes:UP000004261};
RN   [1] {ECO:0000313|EMBL:EHI48474.1, ECO:0000313|Proteomes:UP000004261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=strain HIMB100 {ECO:0000313|Proteomes:UP000004261};
RX   PubMed=22675578; DOI=10.4056/sigs.1854551;
RA   Grote J., Bayindirli C., Bergauer K., Carpintero de Moraes P.,
RA   Chen H., D'Ambrosio L., Edwards B., Fernandez-Gomez B., Hamisi M.,
RA   Logares R., Nguyen D., Rii Y.M., Saeck E., Schutte C., Widner B.,
RA   Church M.J., Steward G.F., Karl D.M., Delong E.F., Eppley J.M.,
RA   Schuster S.C., Kyrpides N.C., Rappe M.S.;
RT   "Draft genome sequence of strain HIMB100, a cultured representative of
RT   the SAR116 clade of marine Alphaproteobacteria.";
RL   Stand. Genomic Sci. 5:269-278(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EHI48474.1}.
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DR   EMBL; AFXB01000010; EHI48474.1; -; Genomic_DNA.
DR   RefSeq; WP_009605752.1; NZ_AFXB01000010.1.
DR   EnsemblBacteria; EHI48474; EHI48474; HIMB100_00020580.
DR   PATRIC; fig|909943.3.peg.2122; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004261; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004261};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004261}.
FT   DOMAIN      198    329       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      409    478       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     206    213       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   502 AA;  56510 MW;  2D50C634EEE5327A CRC64;
     MTDLDAKNQE MAMKGTIRRQ PFAGATGDQP SESPLAERHD GPDKASLHMG WQRISHKLKG
     DLGEAKWKAW IKPLTCEAID DSLLILRADT SFLRDRVLSN YAEKLRLLAK SEFDGVQAVD
     VVLHGAERAS PLASQSAPAG DYPPRMTSAM GKTEATPHLA GPVEGLDSRL TFDNFIVGKP
     NQLAFAIAKR VAESAEATYN PLFLYGGVGL GKTHLMHAIA WEINHRQPHR KVMYLSAEKF
     MYRFIRALRY RDMMSFKEQF RSVDVLMIDD VQFISGKDST QEEFFHTFNA LVEDGRQVVL
     SADKSPTDLS GMEERLRSRL GWGMVADIHP ADYELRLGIL QARRDKSGVD VSDKVLDFLA
     RKITSNIREI EGAFNRIVAH ATLVGREITV ETSRELLADL LRASSRRITV DDIQKQVASH
     FHIRVADMFS ARRSRQIARP RQIAMYLAKN LTSLSYPEIG RRFGNRDHTT IMHAVRKVEE
     LMVTDTELAN DVNLLKSVLS DH
//
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