ID   G6A1K1_9PROT            Unreviewed;       470 AA.
AC   G6A1K1;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Leucyl aminopeptidase {ECO:0000313|EMBL:EHI48586.1};
GN   ORFNames=HIMB100_00021710 {ECO:0000313|EMBL:EHI48586.1};
OS   SAR116 cluster alpha proteobacterium HIMB100.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; SAR116 cluster.
OX   NCBI_TaxID=909943 {ECO:0000313|EMBL:EHI48586.1, ECO:0000313|Proteomes:UP000004261};
RN   [1] {ECO:0000313|EMBL:EHI48586.1, ECO:0000313|Proteomes:UP000004261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=strain HIMB100 {ECO:0000313|Proteomes:UP000004261};
RX   PubMed=22675578; DOI=10.4056/sigs.1854551;
RA   Grote J., Bayindirli C., Bergauer K., Carpintero de Moraes P., Chen H.,
RA   D'Ambrosio L., Edwards B., Fernandez-Gomez B., Hamisi M., Logares R.,
RA   Nguyen D., Rii Y.M., Saeck E., Schutte C., Widner B., Church M.J.,
RA   Steward G.F., Karl D.M., Delong E.F., Eppley J.M., Schuster S.C.,
RA   Kyrpides N.C., Rappe M.S.;
RT   "Draft genome sequence of strain HIMB100, a cultured representative of the
RT   SAR116 clade of marine Alphaproteobacteria.";
RL   Stand. Genomic Sci. 5:269-278(2011).
CC   -!- SIMILARITY: Belongs to the peptidase M17 family.
CC       {ECO:0000256|ARBA:ARBA00009528}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHI48586.1}.
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DR   EMBL; AFXB01000010; EHI48586.1; -; Genomic_DNA.
DR   AlphaFoldDB; G6A1K1; -.
DR   STRING; 909943.HIMB100_00021710; -.
DR   PATRIC; fig|909943.3.peg.2237; -.
DR   eggNOG; COG0260; Bacteria.
DR   OrthoDB; 9809354at2; -.
DR   Proteomes; UP000004261; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00433; Peptidase_M17; 1.
DR   Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR011356; Leucine_aapep/pepB.
DR   InterPro; IPR043472; Macro_dom-like.
DR   InterPro; IPR000819; Peptidase_M17_C.
DR   InterPro; IPR048816; Peptidase_M17_N_1.
DR   PANTHER; PTHR11963:SF53; AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR   Pfam; PF00883; Peptidase_M17; 1.
DR   Pfam; PF21337; Peptidase_M17_N_1; 1.
DR   PRINTS; PR00481; LAMNOPPTDASE.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR   PROSITE; PS00631; CYTOSOL_AP; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW   ECO:0000313|EMBL:EHI48586.1}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004261}.
FT   DOMAIN          310..317
FT                   /note="Cytosol aminopeptidase"
FT                   /evidence="ECO:0000259|PROSITE:PS00631"
SQ   SEQUENCE   470 AA;  49796 MW;  7F649D372A41C28C CRC64;
     MTILSCRTGL TPFSEDSLTL FVVEEHQFEA FMAARSEQQQ QWMTANSFTA KPGRHICLPD
     QSGEIAGAVV ITGQATLWDI AGAATALPIK SWAPDLSFAP ETDLSTLQLG WGLAQYRYAP
     HKQDDRDKKL PLLALDETQI STDSSALVLG THISREMVNR PANQMTPEGI EAAAREVAEA
     CSAEIKVVSG AALPDYAPAL HIVGRAAEIG PRMIELNWGD SGPAITLVGK GISFDSGGLD
     IKPSKAMEIM KKDMGGAAHV LGIAAALMTA GVACRLRVLI AAAENAISAQ SMRPLDVIDT
     AAGIAVEVGN TDAEGRLVLA DALYHALQDE THPEPAFLLD FATLTGAARI ALGTECPALF
     CNQPETGQTL MALGAELHDP VWQLPLFDAY DRYLDSGQAG LSSTGNAGGY GGAITAALFL
     RRFTGRTVNW AHIDVMAWNL SAQPGRPKGG EAMGLRTSFA YIKKLADAAQ
//