ID G6C7M5_9STRE Unreviewed; 324 AA.
AC G6C7M5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=tagatose-bisphosphate aldolase {ECO:0000256|ARBA:ARBA00012905};
DE EC=4.1.2.40 {ECO:0000256|ARBA:ARBA00012905};
DE Flags: Fragment;
GN ORFNames=HMPREF9184_00299 {ECO:0000313|EMBL:EHI77717.1};
OS Streptococcus sp. oral taxon 058 str. F0407.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=861455 {ECO:0000313|EMBL:EHI77717.1, ECO:0000313|Proteomes:UP000006417};
RN [1] {ECO:0000313|EMBL:EHI77717.1, ECO:0000313|Proteomes:UP000006417}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0407 {ECO:0000313|EMBL:EHI77717.1,
RC ECO:0000313|Proteomes:UP000006417};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC Evidence={ECO:0000256|ARBA:ARBA00000567};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2. {ECO:0000256|ARBA:ARBA00005191}.
CC -!- SIMILARITY: Belongs to the aldolase LacD family.
CC {ECO:0000256|ARBA:ARBA00008679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHI77717.1}.
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DR EMBL; AGAE01000021; EHI77717.1; -; Genomic_DNA.
DR AlphaFoldDB; G6C7M5; -.
DR STRING; 861455.HMPREF9184_00299; -.
DR eggNOG; COG3684; Bacteria.
DR HOGENOM; CLU_058971_0_1_9; -.
DR UniPathway; UPA00704; UER00716.
DR Proteomes; UP000006417; Unassembled WGS sequence.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-EC.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:InterPro.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR HAMAP; MF_00734; LacD; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR NCBIfam; TIGR01232; lacD; 1.
DR PANTHER; PTHR39340; SULFOFRUCTOSEPHOSPHATE ALDOLASE; 1.
DR PANTHER; PTHR39340:SF1; SULFOFRUCTOSEPHOSPHATE ALDOLASE; 1.
DR Pfam; PF01791; DeoC; 1.
DR SMART; SM01133; DeoC; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lactose metabolism {ECO:0000256|ARBA:ARBA00022736};
KW Lyase {ECO:0000256|ARBA:ARBA00023239}.
FT NON_TER 324
FT /evidence="ECO:0000313|EMBL:EHI77717.1"
SQ SEQUENCE 324 AA; 35927 MW; 274253CD2C37A91A CRC64;
MTIKNKEVSM SKLQLSPNKV ACLKKLSDEN GIISALAFDQ RDALKRLMAQ YQTEEPTVAQ
MEELKVLVAD ELTKYASSML LDPEYGLPAT KALDANAGLL LAYEKTGYDT TSTKRLPDCL
DVWSAKRIKE QGADAVKFLL YYDVDSADEL NQQKQAYIER IGSECVAEDI PFFLEILAYD
EKIADAGSAE YAKVKPHKVI GAMKVFSDPR FNIDVLKVEV PVNVKYVEGF GDGEIVYTRE
EAAAFFKAQD EATNLPYIYL SAGVSAKLFQ ETLVFAHESG ANFNGVLCGR ATWAGSVEAY
IKDGEAAARE WLRTTGFENI DELN
//
