ID G6EIL4_9SPHN Unreviewed; 403 AA.
AC G6EIL4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:EHJ58956.1};
GN ORFNames=NSU_4185 {ECO:0000313|EMBL:EHJ58956.1};
OS Novosphingobium pentaromativorans US6-1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1088721 {ECO:0000313|EMBL:EHJ58956.1, ECO:0000313|Proteomes:UP000004030};
RN [1] {ECO:0000313|EMBL:EHJ58956.1, ECO:0000313|Proteomes:UP000004030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=US6-1 {ECO:0000313|EMBL:EHJ58956.1,
RC ECO:0000313|Proteomes:UP000004030};
RX PubMed=22275104; DOI=10.1128/JB.06476-11;
RA Luo Y.R., Kang S.G., Kim S.J., Kim M.R., Li N., Lee J.H., Kwon K.K.;
RT "Genome sequence of benzo(a)pyrene-degrading bacterium Novosphingobium
RT pentaromativorans US6-1.";
RL J. Bacteriol. 194:907-907(2012).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHJ58956.1}.
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DR EMBL; AGFM01000064; EHJ58956.1; -; Genomic_DNA.
DR AlphaFoldDB; G6EIL4; -.
DR STRING; 1088721.JI59_02890; -.
DR PATRIC; fig|1088721.3.peg.4122; -.
DR eggNOG; COG0183; Bacteria.
DR Proteomes; UP000004030; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF144; ACYL-COA THIOLASE-RELATED; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000004030};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EHJ58956.1}.
FT DOMAIN 16..272
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 280..401
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 100
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 359
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 389
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 403 AA; 41540 MW; E55C9F1081D0A855 CRC64;
MQKGKVMAQI SANDPIVILS YARTPMGGLQ GVFADVSATD LGATAVKAAV ERSGVAGEDV
ERIYMGCVLP AGLGQAPARQ AALKAGLPKS VQATTVNKVC GSGMQTVIMG AEALASGSLD
LIIAGGMESM TNAPYLSKKH RSGARAGHDT LYDHMFLDGL EDAYEGGSMG SFAQVTADEY
QLTRENQDDF SIESLRRAQE AITSGAFKDE VVPVTVKTRK GEVVVDTDEQ PPKGNPDKIR
TLRAAFAKDG TITAASSSSI SDGAAAVVMS RASVAAAKGL KPVATVVGVA AHAHEPAKFT
TAPVGAITKL LDKVGWQLSD VDLFEVNEAF ACVAMFAMHD LGIPHDKINI HGGATALGHP
IGASGTRIIV TLINALKDKG LKRGVASLCI GGGEATAIAV ELA
//
