ID G7DWX8_MIXOS Unreviewed; 1785 AA.
AC G7DWX8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Actin cytoskeleton-regulatory complex protein PAN1 {ECO:0000256|ARBA:ARBA00015110};
DE AltName: Full=Actin cytoskeleton-regulatory complex protein pan1 {ECO:0000256|ARBA:ARBA00020728};
GN Name=Mo01730 {ECO:0000313|EMBL:GAA95075.1};
GN ORFNames=E5Q_01730 {ECO:0000313|EMBL:GAA95075.1};
OS Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC Mixiales; Mixiaceae; Mixia.
OX NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA95075.1, ECO:0000313|Proteomes:UP000009131};
RN [1] {ECO:0000313|Proteomes:UP000009131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC {ECO:0000313|Proteomes:UP000009131};
RX PubMed=21478649; DOI=10.2323/jgam.57.63;
RA Nishida H., Nagatsuka Y., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL J. Gen. Appl. Microbiol. 57:63-67(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA95075.1}.
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DR EMBL; BABT02000054; GAA95075.1; -; Genomic_DNA.
DR RefSeq; XP_014566682.1; XM_014711196.1.
DR STRING; 764103.G7DWX8; -.
DR GeneID; 26266362; -.
DR eggNOG; KOG0998; Eukaryota.
DR eggNOG; KOG4305; Eukaryota.
DR HOGENOM; CLU_235129_0_0_1; -.
DR InParanoid; G7DWX8; -.
DR OMA; DATVYKY; -.
DR OrthoDB; 2734911at2759; -.
DR Proteomes; UP000009131; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00052; EH; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR46006:SF5; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF12763; EF-hand_4; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00027; EH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 2.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50031; EH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000009131};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 260..349
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 293..328
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 1036..1053
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 1201..1260
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1471..1649
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1688..1777
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1372..1395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1409..1441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..651
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..878
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..985
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1097
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1292
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1785 AA; 193836 MW; 3774B562F934FBF9 CRC64;
MQGYGQQPYY GQQPQQQPQQ AGQAYGQPMQ PQATGYPGMQ QQPGSFYGAQ AQAQQQQPPP
MLQQPSFLST QPTGYGAMGM MQPQPTGYMR PQPTGFGGSQ LGSNLPAPGQ PSMYMQQQQQ
QSQATRPNVV SAQGNFMSGP STGQLTPMPQ MQRPMSTGYP GQATNVSGLM PQQTGYPGSS
VFGPGAMMGG GMGAIGSTFV NTFLPANPAQ VPQYQQMGGH LQFNTSGLGG QSLQQTVAQR
NEQQLGTANV KVPWALTADE KKNYDQIFRA WDVQGTGFIS GQMSKEVFGQ AGIDRDDLMK
IWNLADTENR GKLNLAEFHV AMGLIYRRLN GNPVPDILPA ELVPPSARDL DTSVDFLKDL
LKNDNQQRAA SASKFPDISG NGSVNKAKVH SFRDTASPPT RKDATIYKHD DTDTTTYRSG
SRHIDRSRVR FGGNTSSDLD DMKRQLSSSE AMLRDTRSNE EEDEALQDEK DELMLQIRRV
QEDIERNRRA RPSDRKDTER RKLERDLDYL RLDKLPQLED KIAEREKQKA RERRKEAIER
DERANRKRFD LPPRSSRKKP SSRYDSADDD DDEDYASRRR DDRRSARSSR RRDSDSGGSS
PDRRDRPRSR DRKPASPPPK AREAPAKPAP SSPKPAVSSP PPPPPPQSPP ALQTAEDRAA
FIRAEAQRRV QERLKALGLS SGSAAAPSPD TSLAARMQRE QAEAAERSAQ ADKDASEREA
QRQLRLEKER MKDVKAEEAQ IKLASNAVQQ VSDEVTGSSM AAPSSTGAVQ KAAREALERE
EASVREQAEA LEREKAARQA HIAKLEEEVA AAKEQEANFA RSKAAFSAKP AAKAAPPPPP
ASRKRAPLAS MATAPASAPV PPQAPPAPPA PQIPAPSPPA AARAVVEAPA ALPAPSAPAQ
PAGSSSSNPF HRMGASVSPQ PIANGTGSNP FYRPNGASPA LSNTPSEPPR APAFKKPATD
DDDGWDAPKE TSDNDSSDDE GALSSRARRA GLANVIFGGI MPPTSRPASS QATEAPKPPP
APKAPVVIAT TSEPPPRGAL LGEIQGGLKL RKAQTNDRST AGIAGRVIGD PSPPVQTYVQ
PPSPVAPPTP ITEQPRSVPA PVLPSAESSD DEADFADASA GLQRSASPDP APSDNYDRSR
SERCYAVYPY DDPSKPGDIS VDENAVLKTH RALDNTDWLY AIAESGSAKG WLPATYVQPV
TNSRHTKALY AYQATSSEEI DLNEGETIEV FGDSDSDWTK AIKAGRIGLV PSAYLESEGS
KAMDLSPPIQ SRSDSASSAD DDDEESDSDS EDRQADAEAR QKERMRVLEA AGLLQKTRLE
RRAAPEPPPK SSPLTKPIRA SSASEDAARA TDDAYDRWQK LQKDLPAVPP IASVPVLSTP
PAADRTSPVL SDTHKSSRTA ALLSWVTGAT QGRSSAGSPS TDKLRVSGPL NRSRSGSDVT
SIPAVTSAMG RSWSSLIEPS ALQDVPDQER KRQESIFELI ETEKAYVRNL QLTVQTFYAP
LEPVLGSEAS QAIFANLESI LVFNTMLLSD LEARQADARL YVDRIGDVVL RHAQDLEVYL
PYCSNQSNAN TCLTELKRSN AQVAKICEES RIKDLELEHF LLLPMQRLTR YPLLLQHILH
YTDEHHPDQV DLAKSTAIAE AVLKTTNENI RRQESDSVLA HLSQTLHFAG SSTGIDLTGN
TRRQGPRLML QEGTLTKIRS TRSSKLQAYL CNDILLLVSP PDQIYKNPLP LEECSVHADN
RDDCTFQVRY HGTTVRLRAG TARLAMAWLK DITKAQADCL AARSS
//
