ID G7DY60_MIXOS Unreviewed; 445 AA.
AC G7DY60;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=GPN-loop GTPase {ECO:0000256|RuleBase:RU365059};
DE EC=3.6.5.- {ECO:0000256|RuleBase:RU365059};
GN Name=Mo02175 {ECO:0000313|EMBL:GAA95520.1};
GN ORFNames=E5Q_02175 {ECO:0000313|EMBL:GAA95520.1};
OS Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC Mixiales; Mixiaceae; Mixia.
OX NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA95520.1, ECO:0000313|Proteomes:UP000009131};
RN [1] {ECO:0000313|Proteomes:UP000009131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC {ECO:0000313|Proteomes:UP000009131};
RX PubMed=21478649; DOI=10.2323/jgam.57.63;
RA Nishida H., Nagatsuka Y., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL J. Gen. Appl. Microbiol. 57:63-67(2011).
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU365059}.
CC Nucleus {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA95520.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BABT02000062; GAA95520.1; -; Genomic_DNA.
DR RefSeq; XP_014570030.1; XM_014714544.1.
DR AlphaFoldDB; G7DY60; -.
DR STRING; 764103.G7DY60; -.
DR GeneID; 26268206; -.
DR eggNOG; KOG1532; Eukaryota.
DR HOGENOM; CLU_037460_1_3_1; -.
DR InParanoid; G7DY60; -.
DR OMA; MIIVFNK; -.
DR OrthoDB; 5475185at2759; -.
DR Proteomes; UP000009131; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd17870; GPN1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030230; Gpn1/Npa3/XAB1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF8; GPN-LOOP GTPASE 1; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU365059};
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Reference proteome {ECO:0000313|Proteomes:UP000009131}.
FT REGION 378..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..413
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 49382 MW; 5023C4891526A4D6 CRC64;
MPDFTKSGSI ILVQRLDLAR PKHLRQRLVK RTIGGGDRTC VGPDMISLDQ VKDDVRLLYI
VITSAAPLRN ETSMNEATSS SAVAAQQPTC IIVIGMAGSG KTTFLQRLNS HLHSQSKPPY
ILNLDPAVSH LPFKANIDIR DTVDYSEVMK QYNLGPNGGI LTALNLFTTK FDQVLGFVEK
RAGSHKHVLL DTPGQIEIFT WSASGAIITD SLASSLPTCV AYIIDTPRTT APATFMSNML
YACSILYKTR LPFILVFNKT DVTPHHFALE WMRDFEAFQD ALQQNRQSTD EPGFMNSLLN
SMSLMLDEFY KHLRAVGVSA MTGAGFDDFL RAVDEARKEY ENDYKPELDR LRAEKAAQSA
KNKDEQIQRL VQDMKLSGGQ NEVLSRPSVR ADPAAVGPDE LDQDEDEGEL LERDDEGAPP
PRIPGRRLPG GIYEDDNGGR WPAPR
//
