ID G7E1H0_MIXOS Unreviewed; 834 AA.
AC G7E1H0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=alpha-1,2-Mannosidase {ECO:0000256|RuleBase:RU361193};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361193};
GN Name=Mo03351 {ECO:0000313|EMBL:GAA96680.1};
GN ORFNames=E5Q_03351 {ECO:0000313|EMBL:GAA96680.1};
OS Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC Mixiales; Mixiaceae; Mixia.
OX NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA96680.1, ECO:0000313|Proteomes:UP000009131};
RN [1] {ECO:0000313|Proteomes:UP000009131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC {ECO:0000313|Proteomes:UP000009131};
RX PubMed=21478649; DOI=10.2323/jgam.57.63;
RA Nishida H., Nagatsuka Y., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL J. Gen. Appl. Microbiol. 57:63-67(2011).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR601382-2};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 47 family.
CC {ECO:0000256|ARBA:ARBA00007658, ECO:0000256|RuleBase:RU361193}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA96680.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BABT02000106; GAA96680.1; -; Genomic_DNA.
DR RefSeq; XP_014565205.1; XM_014709719.1.
DR AlphaFoldDB; G7E1H0; -.
DR STRING; 764103.G7E1H0; -.
DR GeneID; 26266420; -.
DR eggNOG; KOG2429; Eukaryota.
DR HOGENOM; CLU_003818_2_1_1; -.
DR InParanoid; G7E1H0; -.
DR OMA; LPEVWDM; -.
DR OrthoDB; 942598at2759; -.
DR Proteomes; UP000009131; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:UniProt.
DR CDD; cd00538; PA; 1.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR044674; EDEM1/2/3.
DR InterPro; IPR001382; Glyco_hydro_47.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR036026; Seven-hairpin_glycosidases.
DR PANTHER; PTHR45679:SF5; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR45679; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2; 1.
DR Pfam; PF01532; Glyco_hydro_47; 1.
DR Pfam; PF02225; PA; 1.
DR PRINTS; PR00747; GLYHDRLASE47.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF48225; Seven-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR601382-2};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosidase {ECO:0000256|RuleBase:RU361193};
KW Hydrolase {ECO:0000256|RuleBase:RU361193};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601382-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000009131};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..834
FT /note="alpha-1,2-Mannosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009955658"
FT DOMAIN 708..794
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT ACT_SITE 132
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 273
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 368
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 387
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT BINDING 473
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-2"
SQ SEQUENCE 834 AA; 92341 MW; 4A8B1B7BDA0FFC23 CRC64;
MRWRTSYWSV IACVWLCVSA GGRARAGPAM SNERKRQLRE LTRETFNHGM RHYMRVAYPQ
AELRPLSCQP LGPSPDPTDE INDVVGHFPL TLIDALDTFV VFQDKAGFER AVKDVLRQLS
SFDMDSKVQV FEVTIRVMGG LLSAHIFASD ETRGFAISGY KGELLSLAQD LGERLLPAFQ
YSLTGMPFAR INLRHGISRT ESTETCTAGA GSLLLEFATL SRLTDNPIYE QVARKAFFSL
WAKRSALNLL GNTIDLQTGA WIYGIASVGA GIDSFMEYMI KAYVLLGDEE YWNVFAESYD
AIQQHVKSSE GHWYRGVNMH SGKIAQTHID SLGAFWPGTQ VLAGDVESAI KGHLVYANIW
ARYSGLPETF SIQNREAVSA GYPLRPEFIE STLYLYRATG DPYYLFVGER FIEDFVNRTR
VDCGLASLKN VKTGGHDDRM HSFVLSETLK YAYLLFDESN PVHKDESNAV WSTEGHYLAV
DRHKLNHSTH PLVSTSPQRG ALRATCVNPV QPTPWTTSIA ARGDADVARA LVNWDVSESF
ALQTGMWSPY SQCAKPELEQ YVRPSTVEVV FSPNGQVEDP NPGADKVIML SNGFVVRKME
GLRLTLTQRP DSGGAYDITR ISQYMIPKGA TVFFADPSVL DAFRHDPQST QEVRLKTRYL
DTAGRHAVES HLGMRATFGP NPLLPNVLSQ THFARNAPMR SLIKPSSTTY GCHPYSVARP
ANPKASGPVV FLLRGHCTFV DKAYYAAQSG ASGLIVSSDH DEALQASGDG EPVDLLAKLS
VPLITVSNST GTRLDELLSV SNRSIQIEAM PPELVPDSKI QINNCLLLNV KLLE
//