ID G7E1U1_MIXOS Unreviewed; 1616 AA.
AC G7E1U1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN Name=Mo03471 {ECO:0000313|EMBL:GAA96801.1};
GN ORFNames=E5Q_03471 {ECO:0000313|EMBL:GAA96801.1};
OS Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC Mixiales; Mixiaceae; Mixia.
OX NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA96801.1, ECO:0000313|Proteomes:UP000009131};
RN [1] {ECO:0000313|Proteomes:UP000009131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC {ECO:0000313|Proteomes:UP000009131};
RX PubMed=21478649; DOI=10.2323/jgam.57.63;
RA Nishida H., Nagatsuka Y., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL J. Gen. Appl. Microbiol. 57:63-67(2011).
CC -!- SIMILARITY: Belongs to the Rho GDI family.
CC {ECO:0000256|ARBA:ARBA00009758}.
CC -!- SIMILARITY: Belongs to the cAMP-dependent kinase regulatory chain
CC family. {ECO:0000256|ARBA:ARBA00005753}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA96801.1}.
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DR EMBL; BABT02000106; GAA96801.1; -; Genomic_DNA.
DR STRING; 764103.G7E1U1; -.
DR eggNOG; KOG0220; Eukaryota.
DR eggNOG; KOG1113; Eukaryota.
DR eggNOG; KOG3205; Eukaryota.
DR HOGENOM; CLU_242929_0_0_1; -.
DR InParanoid; G7E1U1; -.
DR Proteomes; UP000009131; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0005094; F:Rho GDP-dissociation inhibitor activity; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd12098; DD_R_ScPKA-like; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 1.20.890.10; cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain; 1.
DR Gene3D; 2.70.50.30; Coagulation Factor XIII, subunit A, domain 1; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000406; Rho_GDI.
DR InterPro; IPR024792; RhoGDI_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF02115; Rho_GDI; 1.
DR Pfam; PF02197; RIIa; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00394; RIIa; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF47391; Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 2.
DR PROSITE; PS00889; CNMP_BINDING_2; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW cAMP-binding {ECO:0000256|ARBA:ARBA00022566};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009131};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1123..1263
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1266..1386
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1384..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1091
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1616 AA; 176767 MW; 6469C7A5864ADDFB CRC64;
MSVRPPSTRP PTAALSIRRP TTAASTRETT NGGDADWVVA VFEAKGSHRQ VAVAAIDVER
SLCFLSQVCD TQTYVKTLHI IQQRYPATLV LPSQVTTTML TVDSPSASSV GPSPVLSSLT
ILSRLIKNNF EMTPLHGLAK KHWAIDQGIE LIDKLALDEP AKMTLLATVT ENTLALAAFA
GLIRHLEGHH RILYANNSLK IVFTALEGTM VLGTDTLRDL ELLQNTMDGS SKKTLFDLLN
SCMTPMGTRL LRNNITSPSA DRFTLNKRLD AVQELVINRD TLETCRQALH KLAKTDYDKV
IGKISTNKPR DFRGQGDPAR EAEKKISTVL QLRTLLESLP SIALSIDASS SDLLKDLASG
LRGQADVILD SLRDTINEDV VTSFQEGKGQ LALRNVRVYA IRSERKLLLD VARVTYKENM
QDLLDMANEM SAIAGTTVNL VPVSSGFAFS CSKDGLPGGV LPKGCTEGKA KSGKRIQFAS
ADLKKRNARL QQSLEEVFLL SDEAIDELIE GIKQHLAFLF QCVEAISTLD VIASLAYVAT
IEGWTRPEFE NAMAIKAGRH PLVERYQMRD RNDFIPNDTY ISNNRSFQLI TGINAAGKTV
FTKQVALLVI MAQLGSFVPA DLASFGIHDA LLTRLNNDDD LGKSLSTFAV EMRSASMITL
ALDAFRAPLV VIDELGRGTD PVAGFGLCHA IAEEIIKKRA FCLFVTHFRE LTLSLFGYSN
VAQFHLEAKA RRSSSAFSFE YRHHVQQGSN AETHYGSLSD SLPVCSPDAE VKTGLEAAKL
VDLPSSMLDF AHQVSDKLAH LERKSRIDAQ STRDEVRRKE MLRIVDQLEE LALARELSDV
EIGDRMRVLQ ADLVEGLVRS SFAGRGQIKA DVKLENRPAC AGRWSTFVAV MTSTYSSILN
DLNRDVARNQ PADIWQFCAN WFNARLEEQR AATRPVERSV TPADQSRPIS PPANVIPAMR
SSPTKREVIR KKSNPSMLGA AYSFGGLGSG IAPADPAPSP FSETPPALKH QTADSFGHDH
PVVSGNGRAN SGLRNEMPSA WQRSGRPRAP MTSAPSDDEG DSGGDDGPSS PGPPPNYNIG
RRTSVSAESL DPDAAQTALP KTVIPKTASQ RQRIEHSIEH NLLFRNLDED QYNDVLNAMK
EVRVPTGSEV IVQGAVGDYF YVVEEGVFEV WVRPSSAGTY GPDGQRASGP NYGKDSDAKH
VATIESGGSF GELALMYNAP RSATVVAVSA TSTLWALDRV TFRSILMEHT SRKRRMYETF
LSEVPILVSL ESHERAKIAD ALEARIYEEG EAIVKEGEVG KNFYIIESGS CEVTKRRPTG
EERVVILRKG DYFGELALLN SAPRAATVRA IGDRVRVATL GSRAFHRLLG PCVEILQRRA
GSYNSAPAAE PRRGLPGNTR SIQPDTAGPR SRGLGMVTAE QHWNRHHARP QVTMTDVDDA
DLVSESQYKA PAAPKDLEKL EFRDDSLKKQ EEALGVGANA TGKARVTVLA LVLTSDSRPE
PIVLDLTKPL PEAPLVIKEG ATYTAELRFQ VEDALVSGLR YLQVVKRAGI KVDRIEAMIG
SFAPSAQVLS KKFESEEAPS GMIVRTGTYN VRSRCTDDDG TICADFAWSF KIGKDW
//
