ID G7E6C7_MIXOS Unreviewed; 1313 AA.
AC G7E6C7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Mo05073 {ECO:0000313|EMBL:GAA98387.1};
GN ORFNames=E5Q_05073 {ECO:0000313|EMBL:GAA98387.1};
OS Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC Mixiales; Mixiaceae; Mixia.
OX NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA98387.1, ECO:0000313|Proteomes:UP000009131};
RN [1] {ECO:0000313|Proteomes:UP000009131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC {ECO:0000313|Proteomes:UP000009131};
RX PubMed=21478649; DOI=10.2323/jgam.57.63;
RA Nishida H., Nagatsuka Y., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL J. Gen. Appl. Microbiol. 57:63-67(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA98387.1}.
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DR EMBL; BABT02000150; GAA98387.1; -; Genomic_DNA.
DR RefSeq; XP_014569106.1; XM_014713620.1.
DR STRING; 764103.G7E6C7; -.
DR GeneID; 26264700; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_260512_0_0_1; -.
DR InParanoid; G7E6C7; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000009131; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113:SF369; CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000009131}.
FT DOMAIN 855..980
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1052..1293
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..380
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1313 AA; 142080 MW; 68AC8A83D7887CEC CRC64;
MDFFKRKGRP STLVVPSAVS TSASVQLQEG NARADLATAP GTMTASSSSS ESFKSSKEAV
SSSSSDAQHG QQYSERRLVL PDTVSAKEAD TFMPDELLRA LDRDPSLSPK PALLGQSAGL
AKSLGPPVSG QSLNSGTIGL MDDHGQAVQV AFPTNQTTPT RSNGSRRTTG IGPSHSDGIA
AAELPTLPAM SPFAMTASPS STPSPHPTGV LAAQSTYHPS AADSRQSAIK SVLQQSFAAD
PIAPTAVTVP ATLLTPVKTT SRPITASLSP SQRLHAAMFG EPELDPVTSE PHSLLPNAPS
TSEESPHSRS TSLEMTSAKK SIYPTDYTDR KSMPAFISQA PQSVVQSTSE DMLETSLPRE
NHVVDIMQAR HRRSSETLTR TNQEEELSPL ESAEERAFPS VGASPTSPGS SFTDRLRSHR
LRAAGPDLSL RQDEEAPSPP PKSPHMLPPI HDASTKRSTA KPASSTSQVS SQQRAMLAAL
ITSEQPQQSS IAPPLTASTA SRTSMSSTER SIAGEHHWQS TLDRDRLGSD TPQRRSHADF
VIAVIGARGV GKTTIIHRGL RKPLGTEIRG EPGGIICYSA AVIAGGQNRL IEVYELTDEH
VSMSTSGLSL PNAVPQIDGA MLCYDASNPG ALTGLRGLLN AFWRRGGVNL IVLACKSSPI
ESQNAVLPMR AAEMCTVYGA GIVQLDGGLA DPSKKTRNSF GWLIRSILET RGLQVGADSS
SRGSKTLSAQ AESRTWTEME PRDVPEHSRH SSPAAYLRRQ SVDRQGPPRN DLGLGTVQSA
PVNGEPQDRT TSLESRLSIS EDSREASTPR SRHSVVSVSS KSSAGAPSSA GSILIDRRSS
TQGNSILGGY SGRSVAADVY HSTDEVIDKF LFAAVTGNDE QQVVLFLIIY RRFAAPAHVL
KKLIERYEFV STRLKSDPVL SRYAHTRLCS VLADWLEYYP GDFTSVRVRA LIKPFLEGLV
LQAYVSRYAI ELLPMLRKLE DADDLDNYWA CPDPSVESPV PEAVEAIAPP QIPANASSIA
SRLSVRPSTD TSRIIHQSSN LLATAISLLN DTEDAIAEQI SRLTWRAYLV MSSRDLIRYI
LAPRNPTDPS GSRLRAANNP VTRAISWVNH LSNWVASVIL ILPRAKMRAR MMEKMIGVAV
RLRETDNYDA LMGLLAGLNC QPLYRLENTL DLIKDRPLFK KFKSLNRLMS STRSFSAYRM
ALSTSRPFVI PYIGCHLQDL ARLDEGKSDM RSGLINWTKF QQMAKSAATV FDCHKFAPEL
AVDQGVTNRV MNDAIFDLND NALYELSYQY QPRATSASSA PSALRRMFDN VRS
//
