ID G7GU20_9ACTN Unreviewed; 725 AA.
AC G7GU20;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Putative drug resistance protein {ECO:0000313|EMBL:GAB07095.1};
GN ORFNames=GOAMR_61_01930 {ECO:0000313|EMBL:GAB07095.1};
OS Gordonia amarae NBRC 15530.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1075090 {ECO:0000313|EMBL:GAB07095.1, ECO:0000313|Proteomes:UP000006023};
RN [1] {ECO:0000313|EMBL:GAB07095.1, ECO:0000313|Proteomes:UP000006023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 15530 {ECO:0000313|EMBL:GAB07095.1,
RC ECO:0000313|Proteomes:UP000006023};
RA Takarada H., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Gordonia amarae NBRC 15530.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB07095.1}.
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DR EMBL; BAED01000061; GAB07095.1; -; Genomic_DNA.
DR AlphaFoldDB; G7GU20; -.
DR STRING; 1075090.GOAMR_61_01930; -.
DR eggNOG; COG0477; Bacteria.
DR Proteomes; UP000006023; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17502; MFS_Azr1_MDR_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR004638; EmrB-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00711; efflux_EmrB; 1.
DR PANTHER; PTHR23501:SF197; COMD; 1.
DR PANTHER; PTHR23501; MAJOR FACILITATOR SUPERFAMILY; 1.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01036; TCRTETB.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006023};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 62..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..541
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 27..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 76692 MW; 80DFE2412ECC0543 CRC64;
MPDESDNSAL FRENAANLTP AARSCAYDDA NSEEEHVTST TAEAGPSESS GGLTVSVTQR
NWIFGTIVVG MLLAALDSTI VSTALPTIVG DLGGGGHMSW VVTSYLLAQT VSTVLAGKFG
DLYGRKAIFI SAIVVFIVGS FFCGLAGNMA WLIIARAVQG IGGGAITVTA TALIADVIPL
RDRGKYQGAL GAVFGVTTVI GPLLGGLFTD HLSWRWAFYI NVPIALIVIP LALKTIPGIS
ERIQSKIDYL GIIFVSLGAV AVTLGLSWGG SEYDWGSVQI IGLFVGSAVS FVIFVFAERR
AAEPILPMHL FAKRVFTICS ILSFIVGFAM MGAMTFLPTF LQYVQGTSAT DSGLRMLPMV
IGLLITSILA GGYVGKTGQY KMFPIAGSAV IALGLFLLSL MDENTSILVT SLYIFIIGLG
IGLTMQVLTL VVQNTASYAD LGTATSAVTF FRTLGMSFGA SVMGTLYSNK LSSDLPGAIM
SAKLTDPAAA TSPVSLHKLP DAQKAPIIHA YADALHNVFL WVVPVAILAL LLAVFMPQVP
MREAAKESAT GPSEGFGMPE QVSSRVQLET IVGRILRRHG RDAILRNVIA DSGRDIDVAT
AWGLLSVGIR SRFLGVSMSQ SSLEQRIGLP EGVLSSFYDS IVEKGYLTRD GDTLNLTDGG
RSEVETLARA WRDWLVGQVR DWLPEDADAA DDATLAADVT AALDRIGRRA LEESNQTGGG
GYVLA
//
