ID   G7GZ68_9ACTN            Unreviewed;       440 AA.
AC   G7GZ68;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Putative peptidase S8 family protein {ECO:0000313|EMBL:GAB08893.1};
GN   ORFNames=GOARA_021_01300 {ECO:0000313|EMBL:GAB08893.1};
OS   Gordonia araii NBRC 100433.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1073574 {ECO:0000313|EMBL:GAB08893.1, ECO:0000313|Proteomes:UP000035088};
RN   [1] {ECO:0000313|EMBL:GAB08893.1, ECO:0000313|Proteomes:UP000035088}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 100433 {ECO:0000313|EMBL:GAB08893.1,
RC   ECO:0000313|Proteomes:UP000035088};
RA   Yoshida Y., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA   Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia araii NBRC 100433.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC       Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB08893.1}.
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DR   EMBL; BAEE01000021; GAB08893.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7GZ68; -.
DR   STRING; 1073574.GOARA_021_01300; -.
DR   Proteomes; UP000035088; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR023834; T7SS_pept_S8A_mycosin.
DR   NCBIfam; TIGR03921; T7SS_mycosin; 1.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          68..369
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        77
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        108
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        322
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   440 AA;  44175 MW;  CAAA5227F7B3AD58 CRC64;
     MGTAPVGANP FGPPAVAFVA PPDEAGPPGR AEQRTRCAVP VASSRVTPAT RAVRALLDID
     RLHRISTGRG QTVAIIDTGV TPHPRLPAVR DGGDYVTARG GRDDCDAHGT LVAGLIAARP
     GGADGFVGLA PDVALISIRQ SSAAFSPARR ADDRTEATVG SGYGSVASLA AAVMRAVRLG
     ATVVNISEVA CSPSAARSAL GDAGLGAALR HAVDRNVVVV VAAGNVSGEG GCREQNPTSS
     RAQRWSAVRT VATPAWFSDY VLTVASVDST TGAPSPFSLA GPWVSIAAPG TDLTSLDSRP
     GRSGLVSGIS GSDGAVPISG TSFAAAYVAG TVALVRARHP ELDAHAVMKR ITATATGHGD
     VPDARVGHGL IDPLAALTAE IPASEGVAAV RFRPAPSAPA RSSIPSIVAV GGAIALVVAL
     AVMSGCLRSR HRITPFDDGL
//