ID G7IK73_MEDTR Unreviewed; 1052 AA.
AC G7IK73; A0A0C3UXW6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Glutamate receptor 3.4 {ECO:0000313|EMBL:AES63955.2};
GN OrderedLocusNames=MTR_2g015270 {ECO:0000313|EMBL:AES63955.2};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES63955.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES63955.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES63955.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES63955,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES63955.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES63955,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES63955}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES63955};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; CM001218; AES63955.2; -; Genomic_DNA.
DR RefSeq; XP_003593704.2; XM_003593656.2.
DR AlphaFoldDB; G7IK73; -.
DR STRING; 3880.G7IK73; -.
DR PaxDb; 3880-AES63955; -.
DR EnsemblPlants; AES63955; AES63955; MTR_2g015270.
DR Gramene; AES63955; AES63955; MTR_2g015270.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_007358_0_2_1; -.
DR Proteomes; UP000002051; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR CDD; cd13686; GluR_Plant; 1.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 3.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF457; GLUTAMATE RECEPTOR 3.4; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 2.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF00497; SBP_bac_3; 2.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 2.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 2.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037090-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AES63955.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 459..791
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DISULFID 739..795
FT /evidence="ECO:0000256|PIRSR:PIRSR037090-50"
SQ SEQUENCE 1052 AA; 119232 MW; 7893F0621B0D8927 CRC64;
MHYLSTFPQA LARIWLFFVL LVPFALIYGI RDETMNSDNK VISIGVIIDG DSRIGKEQEV
AMDIAAQSYN NTSKNYKLAL YFKNSTKDTL KAIKIAEEMI NVQKVQVIIG MQTWQEAAMV
AEVGSKAQVP VISFVAPTIT PPLMEARWPF LVRLANTGTA YIKCIAEIVQ AYSWKKVVVI
YEDNGYGGDY GMLALLAEAL QDVDSMIEHR LVLPPISSLQ DPEELVSEEM LKLKQTQSRV
FIVLKSSLEM AIHVFKEASK VGLVDKESAW MIPESIANLL DSVNKSAISY MEGALGIKTY
YSERSREYKE FEAQFRRTFW SKNPEEDNRY PGFYALQAYD SINIVTQALN RMTSRKNSSP
KTLLREILSC NFLGLSGHIQ LESGQLMQKN LVLRIVNVAG KSYKELCFWT QQHGFTTIHH
AGQGGNKVAG NTKCFRGVRW PGNWARIPKG WNMPTEKNPL RIAVRSRTSF SRFVKVVYGQ
NGEPDKYTGF CIEIFEHVLN HLGYDLPYSY YPIDGTYNDL VQLVYNKTYD AVVGDMTIIE
ERLPYVDFTV PYAESGLSMI VPMKPGESAW MFMKPFTLEL WLVTGAILIY TMLVVWYLER
EPNPEFQLST ALWFTFSSLF FAHRAEMHSN LTRVVMVSWL FLVLIVTSSY TASLSSMLTV
KQLRPNVTDI QWLKNNNKKI GCDGDSFVRT FLEKVEKFKP ENIINITDEY KYNDAFSNNS
IAAAFLELPY EKVFVSKYCK RYTGFTPRTR FGGFGFMFQK GSPLVKDVSK AILHLSEKAE
LKRLEEKWLI SSQDCSNNVT SSNETNSLNL GSLWVLYVMS GATSTICVLI QTIKWLKSNQ
PHEDLPPEEG NGTPSDERVW KKAITFAKQI YSKKHNNSSK EQDVIDCSSR SGHASIADTP
EHSEELASIP KDVISIGVIV DVNSRIGKEQ ELAEIASQSY SNTSKNYKLV LYFQNSTKDT
LKAIKIAEEM INVQKVQVII GMHTWPEAAI MEDIGSKAQV PIISFAAPTI TPPLMNNRWP
FLVRLANNGT TYIKCIAEIV HAYCWKRVVV IC
//
