ID G7JS40_MEDTR Unreviewed; 1801 AA.
AC G7JS40; A0A0C3X7B6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=1-phosphatidylinositol-3-phosphate 5-kinase {ECO:0000256|ARBA:ARBA00012009};
DE EC=2.7.1.150 {ECO:0000256|ARBA:ARBA00012009};
GN OrderedLocusNames=MTR_4g124590 {ECO:0000313|EMBL:AES92138.2};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES92138.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES92138.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES92138.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES92138,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES92138.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:AES92138.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES92138,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES92138}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES92138};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001220; AES92138.2; -; Genomic_DNA.
DR RefSeq; XP_003609941.2; XM_003609893.2.
DR STRING; 3880.G7JS40; -.
DR PaxDb; 3880-AES92138; -.
DR EnsemblPlants; AES92138; AES92138; MTR_4g124590.
DR Gramene; AES92138; AES92138; MTR_4g124590.
DR eggNOG; KOG0230; Eukaryota.
DR HOGENOM; CLU_000480_4_0_1; -.
DR Proteomes; UP000002051; Chromosome 4.
DR GO; GO:0010008; C:endosome membrane; IBA:GO_Central.
DR GO; GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010256; P:endomembrane system organization; IEA:EnsemblPlants.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009555; P:pollen development; IEA:EnsemblPlants.
DR GO; GO:0007033; P:vacuole organization; IEA:EnsemblPlants.
DR CDD; cd03334; Fab1_TCP; 1.
DR CDD; cd17300; PIPKc_PIKfyve; 1.
DR Gene3D; 3.30.810.10; 2-Layer Sandwich; 1.
DR Gene3D; 3.50.7.10; GroEL; 1.
DR Gene3D; 3.30.800.10; Phosphatidylinositol Phosphate Kinase II Beta; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR InterPro; IPR044769; PIKfyve_PIPKc.
DR InterPro; IPR027483; PInositol-4-P-4/5-kinase_C_sf.
DR InterPro; IPR002498; PInositol-4-P-4/5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45748; 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED; 1.
DR PANTHER; PTHR45748:SF21; 1-PHOSPHATIDYLINOSITOL-3-PHOSPHATE 5-KINASE; 1.
DR Pfam; PF00118; Cpn60_TCP1; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF01504; PIP5K; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00330; PIPKc; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52029; GroEL apical domain-like; 1.
DR SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR PROSITE; PS51455; PIPK; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00781};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PROSITE-
KW ProRule:PRU00781}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00781};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00781}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 36..102
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1451..1775
FT /note="PIPK"
FT /evidence="ECO:0000259|PROSITE:PS51455"
FT REGION 677..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1245..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1801 AA; 200909 MW; B08D85DDFDFB96D8 CRC64;
MGTPDKKISD LVDVVRSWIP RRVEPPNVSR DFWMPDQSCP LCYECDSQFT VFNRRHHCRI
CGRVFCAKCT ANFVPSSPRE PNIGREDWER IRVCNYCFKQ WEKGVAAVDN VTPSATPCLS
PSPSSTSLVS SKSSCTCHSS SSTAGSVPYS TGSYQCVPSS PHQSSQMNLI TDEQENLNSG
MSTNPSEAVE NLNSNQYGYC FNRSDDEDDD YGVYHSDTES RHYSRINDYD DLVNIQGIDR
VYGPHIMHSD GDNIQERSSS CLAPPQNLEL DGTDGVQALG KEADEHDHTD ECETSPYQEE
ANNMEPVDFE NNGLLWLPPE PEDEEDDREA ALFDDDEDEG STGEWGYLRS SASFGSGEFR
SRDKSGENNR KAMKNVVEGH FRALVAQLLQ VESLTVDDDG KESWLDIITT LSWEAATLLK
PDTSRGGGMD PGGYVKVKCI ACGHRNESMV VKGIVCKKNV AHRRMTSKID KPRFIILGGA
LEYQRVSNQL SSVDTLLQQE MDHLKMAVTK IAAHHPNVLL VEKSVSRYAQ EYLLAKDISL
VLNIKRPLLE RIARCTGAQI VPSVDHLSSQ KLGYCEAFHV DKFFEEHGSA GQGGKKLTKT
LMFFEDCPKP LGCTILLKGS NGDELKKPII WRWKHLFLAD EGASPLEFPL KSPITVALPD
KPSSIVKSIS TIPGFSSVTG RGHQGAQTNK EGPKCNDGYK THRTLPSCSG SIERSLAGES
IHMHEISGDV SQLAQDMSSS HCNSFLTNTA FEKDGKERPK ESLHCRQDEG TKTMIHADII
SDFFGTLEPS GRDGNNHIKA VSLASNQGPD PESPIVKHDD NNNNFDNDMI HSKEDFPPST
SDHQSILVFL STRCVWKGTV CERSHLVRIK YYGSSDKPLG RFLKDQLFDE KYTCRSCEMP
PEAHVHCYTH RQGSLTISVK KLSEFPLPGE GEGKIWMWHR CLKCPRVNGF PPATRRVVMS
DAAWGLSFGK FLELSFSNHA AASRVANCGH SLHRDCLRFY GFGKMVACFR YASIDLNSVY
LPPSKLEFNY DSQDWLQKEA HEVHNKAEIL FSEVCSALNQ ISEKFSGSVL QEGGKAVADF
RHLIVELKEI LQKEKEESEV GGLRCCDSSF CIKRAIAGGL MVDVLELCKL RRHILILSFV
WDQRLIYASN QGKITFSEDS KNSYQKVKSI GSKEKAVETD VVTRSARSHS SSDSFLLETK
PDGNLDLENS SHLSQSGEMI KGEDKSKDIG QSKFDLSLSH DANINDKSNS SEFGGAIRRR
RTSSEGGSRN VANLSDTLDA AWTGENHPEN ILYEENGCPA PDVAAVTVHS PTVIATAKSN
LDNYTAGIGG TETGNTHDSK LHSKGLDTRW SGMPFANSYS FDKTSAFNTQ KLVDYNFVHI
LSFRELDRQT GARLLLPVGI NDTIVPVYDD EPTSVIAHVL VSKDYHIQMS DSDRPKDSLE
SSVSLPLFDS TSLLSLNSLD ETITNSYRSF GSSEESMTLS TSGSRMVGDS LLYSKDFHAR
VSFNDDSSLG KVKYNVTCYY AKRFEALRRT CCPSELDFVR SLSRCKKWGA QGGKSNVFFA
KTLDDRFIVK QVTKTELESF IKFAPAYFKY LSESISTGSP TCLAKILGIY QVTSKHLKGG
KETKMDVLVM ENLLYRRNIR RLYDLKGSSR SRYNPDTSGS NKVLLDQNLI EAMPTSPIFV
GNKAKRLLER AVWNDTAFLA SIYVMDYSLL VGVDEEKHEL VLGIIDFMRQ YTWDKHLETW
VKTSGILGGP KNTSPTVISP QQYKKRFRKA MSLYFLMVPD QWSPPSLQTS ESQNDLCDEN
S
//
