ID G7MDG7_MACMU Unreviewed; 400 AA.
AC G7MDG7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Pleckstrin homology domain-containing family O member 1 {ECO:0000256|ARBA:ARBA00019333};
DE Flags: Fragment;
GN ORFNames=EGK_01219 {ECO:0000313|EMBL:EHH15164.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH15164.1};
RN [1] {ECO:0000313|EMBL:EHH15164.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH15164.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CM001253; EHH15164.1; -; Genomic_DNA.
DR AlphaFoldDB; G7MDG7; -.
DR Proteomes; UP000013456; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd13317; PH_PLEKHO1_PLEKHO2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043448; PKHO1/2.
DR PANTHER; PTHR15871; PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15871:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY O MEMBER 1; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 12..123
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 209..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH15164.1"
FT NON_TER 400
FT /evidence="ECO:0000313|EMBL:EHH15164.1"
SQ SEQUENCE 400 AA; 45146 MW; CEC0BEC9D231CD83 CRC64;
QGPQDGNQQP APPEKVGWVR KFCGKGIFRE IWKNRYVVLK GDQLYISEKE VKDEKNIQEV
FDLSDYEKCE ELRKSKSRSK KNHSKFTLAH SKQPGNTAPN LIFLAVSPEE KESWISALNS
AITRAKNRIL DEVTVEEDSY LAHPTRDRAK IQHSRRPPTR GHLMAVASTS TSDGMLTLDL
IQEEDPSPEE PTSCAESFRV DLDKSVAQLA GSRRRADSDR IQPSADRASS LSRPWEKPDK
GATYTPQAPK KLTPTEKGRC ASLEEILSQR DAAPARTLQL QAEEPPSPAP PHPGQLSRIQ
DLVARKLEKT QELLAEVQGL GDGKRKAKDP PRSPPDSESE QLLLETERLL GEASSNWNQA
KRVLQEVREL RDLYRQMDLQ TPDSHLRQTT PHSQYRKSLM
//
