ID G7MDY2_MACMU Unreviewed; 1030 AA.
AC G7MDY2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Rho guanine nucleotide exchange factor 2 {ECO:0000256|ARBA:ARBA00017262};
DE AltName: Full=Guanine nucleotide exchange factor H1 {ECO:0000256|ARBA:ARBA00031760};
GN ORFNames=EGK_01403 {ECO:0000313|EMBL:EHH15329.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH15329.1};
RN [1] {ECO:0000313|EMBL:EHH15329.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH15329.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Cytoplasmic vesicle
CC {ECO:0000256|ARBA:ARBA00004541}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
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DR EMBL; CM001253; EHH15329.1; -; Genomic_DNA.
DR AlphaFoldDB; G7MDY2; -.
DR Proteomes; UP000013456; Chromosome 1.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd20877; C1_ARHGEF2; 1.
DR CDD; cd13393; PH_ARHGEF2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037806; ARHGEF2_PH.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF20; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 84..131
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 279..476
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 516..615
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 727..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1030
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 116223 MW; 37AC843D7F87A737 CRC64;
MLSKSVSMSG INCLLDWSDP DGNLSQSSAI DLGKRCSQLE GHSGTWAGSS LRRTFSFLLG
MTGKAKTREK EKMKEAKDAR YTNGHLFTTI SVSGMTMCYA CNKSITAKEA LICPTCNVTI
HNRCKDTLAN CTKVKQKQQK AALLKNNTAL QSVSLRSKTT IRERPSSAIY PSDSFRQSLL
GSRRGRSSLS LAKSVSTTNI AGHFNDESPL GLRRILSQST DSLNMRNRTL SVESLIDEEV
IYNELMSDFE MDEKDFAADS WSLAVDSSFL QQHKKEVMKQ QDVIYELIQT ELHHVRTLKI
MTRLFRTGML EELQLEPGVV QGLFPCVDEL SDIHTRFLSQ LLERRRQALC PGSTRNFVIQ
RLGDLLISQF SGPSAEQMRK TYSEFCSRHT KALKLYKELY ARDKRFQQFI RKVTRSAVLK
RHGVQECILL VTQRITKYPV LISRILQHSH GIEEERQDLT TALGLVKELL SNVDQDIYEL
EKGARLQEIY NRMDPRAQTP VPGKGPFGRE ELLRRKLIHD GCLLWKTATG RFKDVLMLLM
TDVLVFLQEK DQKYIFPTLD KPSVVSLQNL IVRDIANQEK GMFLISAAPP EMYEVHTASR
DDRSTWIRVI QQSVRICPSR EDFPLIETED EAYLRRIKME LQQKDRALVE LLREKVGLFA
EMTHFQAEED GGSGMALPTL PRGLFRSESL ESPRGERLLQ DAIREVEGLK DLLVGPGVEL
LLTPREPALP LEPDSGGNTS PGVTANGEAR TFNGSIELCR ADSDSSQRDR NGNQLRSPQE
EALQRLVNLY GLLHGLQAAV AQQDTLMEAR FPEGPERREK LCRANSRDGE AGRAGAAPVA
PEKQATELAL LQRQHALLQE ELRRCRRLGE ERATEAGSLE ARLRESEQAR ALLEREAEEA
RRQLAALGQT EPLPAEAPWA RRPVDPRRRS LPAGDALYLS FNPPQPNRGT DRLDLPVTTR
SVHRHFEDRE RQELGSPEER LQDSSDPDTG SEEEGSSRLS PPHSPRDFTR MQDIPEETES
RDGEAVASES
//
