ID G7MFW7_MACMU Unreviewed; 928 AA.
AC G7MFW7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Glutamate receptor {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGK_00568 {ECO:0000313|EMBL:EHH14612.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH14612.1};
RN [1] {ECO:0000313|EMBL:EHH14612.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH14612.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
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DR EMBL; CM001253; EHH14612.1; -; Genomic_DNA.
DR AlphaFoldDB; G7MFW7; -.
DR Proteomes; UP000013456; Chromosome 1.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF174; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 2.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 574..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..854
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 401..811
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 411..475
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 928 AA; 104207 MW; 3D402BAFEFF51CA6 CRC64;
MELLFIEVGE AGRRGDPVLD MSDLMCVSVI QLVMLACDQL ALGVVAIFGP SQGSCTNAVQ
SICNALEVPH IQLRWKHHPL DNKDTFYVNL YPDYASLSHA ILDLVQYLKW RSATVVYDDS
TGLIRLQELI MAPSRYNIRL KIRQLPVDSD DSRPLLKEMK RGREFRIIFD CSHTMAAQIL
KQAMAMGMMT EYYHFIFTTL DLYALDLEPY RYSGVNLTGF RILNVDNPHV SAIVEKWSME
RLQAAPRAES GLLDGVMMTD AALLYDAVHI VSVCYQRAPQ MTVNSLQCHR HKAWRFGGRF
MNFIKEDLTW APPSHDFRAG THLSASKIDV VHEKAQWEGL TGRIVFNKTS GLRTDFDLDI
ISLKEDGLEK VGVWSPADGL NITEVAKGRG PNVTDSLTNR SLIVTTVLEE PFVMFRKSDR
TLYGNDRFEG YCIDLLKELA HILGFSYEIR LVEDGKYGAQ DDKGQWNGMV KELIDHGCGE
FEPTEVEPGG DINLALEEGH SAAGLNLSQY EGHCWDLSRK ADLAVAPLTI THVREKAIDF
SKPFMTLGVS ILYRKPNGTN PSVFSFLNPL SPDIWMYVLL AYLGVSCVLF VIARFSPYEW
YDAHPCNPGS EVVENNFTLL NSFWFGMGSL MQQGSELMPK ALSTRIIGGI WWFFTLIIIS
SYTANLAAFL TVERMESPID SADDLAKQTK IEYGAVKDGA TMTFFKKSKI STFEKMWAFM
SSKPSALVKN NEEGIQRALT ADYALLMEST TIEYVTQRNC NLTQIGGLID SKGYGIGTPM
GSPYRDKITI AILQLQEEDK LHIMKEKWWR GSGCPEEENK EASALGIQKI GGIFIVLAAG
LVLSVLVAVG EFVYKLRKTA EREQRSFCST VADEIRFSLT CQRRVKHKPQ PPMMVKTDAV
INMHTFNDRR LPGKDSMACS TSLAPVFP
//
