ID   G7MQJ6_MACMU            Unreviewed;       439 AA.
AC   G7MQJ6;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   22-FEB-2023, entry version 43.
DE   RecName: Full=Transcription factor AP-2-alpha {ECO:0000256|ARBA:ARBA00020965};
DE   AltName: Full=AP-2 transcription factor {ECO:0000256|ARBA:ARBA00033361};
DE   AltName: Full=Activating enhancer-binding protein 2-alpha {ECO:0000256|ARBA:ARBA00030545};
DE   AltName: Full=Activator protein 2 {ECO:0000256|ARBA:ARBA00030711};
GN   ORFNames=EGK_14461 {ECO:0000313|EMBL:EHH17944.1};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH17944.1};
RN   [1] {ECO:0000313|EMBL:EHH17944.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CR-5 {ECO:0000313|EMBL:EHH17944.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the AP-2 family.
CC       {ECO:0000256|ARBA:ARBA00007770}.
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DR   EMBL; CM001256; EHH17944.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7MQJ6; -.
DR   HOGENOM; CLU_035175_4_1_1; -.
DR   Proteomes; UP000013456; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   InterPro; IPR004979; TF_AP2.
DR   InterPro; IPR008121; TF_AP2_alpha_N.
DR   InterPro; IPR013854; TF_AP2_C.
DR   PANTHER; PTHR10812; TRANSCRIPTION FACTOR AP-2; 1.
DR   PANTHER; PTHR10812:SF8; TRANSCRIPTION FACTOR AP-2-ALPHA; 1.
DR   Pfam; PF03299; TF_AP-2; 1.
DR   PRINTS; PR01749; AP2ATNSCPFCT.
DR   PRINTS; PR01748; AP2TNSCPFCT.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          213..407
FT                   /note="Transcription factor AP-2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03299"
FT   REGION          16..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          416..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..69
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   439 AA;  48261 MW;  167DF286ACBBFA9D CRC64;
     MKMLWKLTDN IKYEDCEDRH DGTSNGTARL PQLGTVGQSP YTSAPPLSHT PNADFQPPYF
     PPPCQPIYPQ SQDPYSHVND PYSLNPLHAQ PQPQHPGWPG QRQSQESGLL HTHRGLPHQL
     SGLDPRRDYR RHEDLLHGPH ALSSGLGDLS IHSLPHAIEE VPHVEDPGIN IPDQTVIKKG
     PVSLSKSNSN AVSAIPINKD NLFGGVVNPN EVFCSVPGRL SLLSSTSKYK VTVAEVQRRL
     SPPECLNASL LGGVLRRAKS KNGGRSLREK LDKIGLNLPA GRRKAANVTL LTSLVEGEAV
     HLARDFGYVC ETEFPAKAVA EFLNRQHSDP NEQVTRKNML LATKQICKEF TDLLAQDRSP
     LGNSRPNPIL EPGIQSCLTH FNLISHGFGS PAVCAAVTAL QNYLTEALKA MDKMYLSNNP
     NSHTDNNAKS SDKEEKHRK
//