ID G7MZB6_MACMU Unreviewed; 984 AA.
AC G7MZB6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Signal peptide, CUB and EGF-like domain-containing protein 2 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=EGK_18937 {ECO:0000313|EMBL:EHH28492.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH28492.1};
RN [1] {ECO:0000313|EMBL:EHH28492.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH28492.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CM001260; EHH28492.1; -; Genomic_DNA.
DR AlphaFoldDB; G7MZB6; -.
DR Proteomes; UP000013456; Chromosome 8.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..41
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 320..358
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 359..399
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 794..906
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 324..334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH28492.1"
FT NON_TER 984
FT /evidence="ECO:0000313|EMBL:EHH28492.1"
SQ SEQUENCE 984 AA; 108412 MW; E74C79C858361B23 CRC64;
DVDECAQGLD DCHANALCQN TPTSYKCSCK PGYQGEGREC EDIDECGNEL NGGCVHDCLN
IPGNYRCTCF DGFMLAHDGH NCLDVDECLE NNGGCQHTCV NVMGSYECCC KEGFFLSDNQ
HTCIHRSEEG LSCMNKDHGC SHICKEAPRG SVACECRPGF ELAKNQRDCI LTCNHGNGGC
QHSCEDTADG PECSCHPQYK MHTDGRSCLE REDTVLEVTE SNATSVVDGD KRVKRRLLME
TCAVNNGGCD RTCKDTSTGV HCSCPVGFTL QLDGKTCKDI DECQTRNGGC DHFCKNTVGS
FDCSCKKGFK LLTNEKSCQD MDECSLDRTC DHSCINHPGT FACACNQGYT LYGFTHCGDT
NECSVNNGGC QQVCVNTVGS YECQCHPGYK LHWNKKDCVE VKGLLPTSVS PRVSLHCGKS
GGGDGCFLRC HSGIHLSSGL QGAYSVTCGS SSPLRSKQQK SNDSAFGDVN TVRTSVTFKL
NEGKCSLKKA ELFPEGLRPA LPEKHSSVKE SFRYVNLTCS SGKQVPGAPG RPSASKEMFI
TVQFELETNQ KEVTASCDLS CIVKRTEKRL RKAIRTLRKA VHREQFHLQL SGMNLDVAKK
PPRTSERQAE SCGVGQGHGE NQCVSCRAGT YYDGAQERCI LCPNGTFQNE EGQITCEPCP
RPGTSGTLKT PESWNVSECG GLCQPGEYSA DGFAPCQLCA LGTFQPEAGR TSCFPCGGGL
LTKHQGATSF QDCETRVQCS PGHFYNTTTH RCIRCPAGTY QPEFGKDNCV SCPGNTTTDF
DGSTNITQCK NRRCGGELGD FTGYIESPNY PGNYPANTEC TWTINPPPKR RILIVVPEIF
LPIEDDCGDY LVMRKTSSSN SVTTYETCQT YERPIAFTSR SKKLWIQFKS NEGNSARGFQ
VPYVTYDEDY QELIEDIVRD GRLYASENHQ EILKDKKLIK ALFDVLAHPQ NYFKYTAQES
REMFPRSFIR LLRSKVSRFL RPYK
//
