ID G7N097_MACMU Unreviewed; 1612 AA.
AC G7N097;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=PDZ domain-containing protein {ECO:0000259|PROSITE:PS50106};
DE Flags: Fragment;
GN ORFNames=EGK_19345 {ECO:0000313|EMBL:EHH28823.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH28823.1};
RN [1] {ECO:0000313|EMBL:EHH28823.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH28823.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the LAP (LRR and PDZ) protein family.
CC {ECO:0000256|ARBA:ARBA00007772}.
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DR EMBL; CM001260; EHH28823.1; -; Genomic_DNA.
DR Proteomes; UP000013456; Chromosome 8.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF44; PROTEIN SCRIBBLE HOMOLOG; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00595; PDZ; 4.
DR SMART; SM00364; LRR_BAC; 9.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50106; PDZ; 4.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 679..766
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 813..901
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 961..1050
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1057..1145
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 366..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1184..1209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1236..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1477..1525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1547..1571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..643
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1410
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH28823.1"
FT NON_TER 1612
FT /evidence="ECO:0000313|EMBL:EHH28823.1"
SQ SEQUENCE 1612 AA; 172405 MW; F67AB538C2DE495B CRC64;
PQPFFRLLNL RKLGLSDNEI QRLPPEVANF MQLVELDVSR NDIPEIPESI KFCKALEIAD
FSGNPLSRLP DGFTQLRSLA HLALNDVSLQ ALPGDVGNLA NLVTLELREN LLKSLPASLS
FLVKLEQLDL GGNDLEVLPD TLGALPNLRE LWLDRNQLSA LPPELGNLRR LVCLDVSENR
LEELPAELGG LVLLTDLLLS QNLLRRLPDG IGQLKQLSIL KVDQNRLCEV TEAIGDCENL
SELILTENLL MALPRSLGKL TKLTNLNVDR NHLETLPPEI GGCVALSVLS LRDNRLAVLP
PELAHTAELH VLDVAGNRLQ SLPFALTHLN LKALWLAENQ AQPMLRFQTE DDARTGEKVL
TCYLLPQQPP SSLEDAGQQG SLSESWSDAP PSRVSVIQFL EAPTGDEDAE EAAAEKRGLQ
RRATPHPSEL KVMKRSIEGR RSEACPCQPD PGSPLPVEEE KRLSAESGLS EDSRPSASTV
SEAEPEGPSA EARGGSQQEA TSAGGEEDAE EDYEEPAVHF AEDALLPGDD RETNEGQPEA
PWTLPGGRQR LIRKDTPHYK KHFKISKLPQ PEAVVALLQG MQPDGEGPVA PGGWHNGPHA
PWAPRAQKEE EEEEEEGSPR EEEEEEEEEE ESRAEEEAST EEEDKEGAVA SAPSVKGVSF
DQANNLLIEP ARIEEEELTL TILRQTGGLG ISIAGGKGST PYKGDDEGIF ISRVSEEGPA
ARAGVRVGDK LLEVNGVALQ GAEHHEAVEA LRGAGTAVQM RVWRERMVEP ENAVTITPLR
PEDDYSPRER RGGGLRLPLL PAESPGPLRQ RHVACLARSE RGLGFSIAGG KGSTPYRAGD
AGIFISRIAE GGAAHRAGTL QVGDRVLSIN GVDVTEARHD HAVSLLTAAS PTIALLLERE
AGGPLPPSPP PHSSSLPTAA VAITSTTTTS ITTATPGEPG LPSLAPSLLA ATLEGPYPVE
EIRLPRAGGP LGLSIVGGSD HSSHPFGVQE PGVFISKVLP RGLAARSGLR VGDRILAVNG
QDMRDATHQE AVSALLRPCL ELSLLVRRDP APPGLRELCI QKAPGERLGI SIRGGARGHA
GNPRDPTDEG IFISKVSPTG AAGRDGRLRV GLRLLEVNQQ SLLGLTHGEA VQLLRGVGDT
LTVLVCDGFD AGSSAALEVS PGVIANPFAA GISHRNSLES ISSIDRELSP EGPGKEKEPP
GQTLHWGPEA TEATGRGLQP LKLDYRALAA VPSAGGVQRV PSGAAGAKMA EAPCSPSGQQ
TPQPPSPDEL PVNVKQAYRA FAAVPTSHPP EDALAQPPTP GPAASPEQLS FRERQKYFEL
EVRVPQAEGP PKRVSLVGAD DLRKMQEEEA RKLQQKRAQM LRDVAEAGAE AGLALDGEAL
GEEEQEDEEP PWAGPSPSSR QSPASPPPLG SGAPVRTAKA ERRHQERLRV QSPEPPVPER
ALSPAERRAL EAEKRALWRA ARMKSLEQDA LRAQMVLSRS QEGRGMRGPL ERLAEAPSPA
PTPSPTPLED LGPQTSTSPG RLPLSGKKFD YRAFAALPSS RPVYDIQSPD FAEELRSLEP
SPSPGPQEED GEVALVLLGR PAPGAVGPED VALCSSRRPV RPGRRGLGPV PS
//
