ID G7N135_MACMU Unreviewed; 1071 AA.
AC G7N135;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 08-NOV-2023, entry version 44.
DE RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
DE Flags: Fragment;
GN ORFNames=EGK_20049 {ECO:0000313|EMBL:EHH19360.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH19360.1};
RN [1] {ECO:0000313|EMBL:EHH19360.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH19360.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR EMBL; CM001261; EHH19360.1; -; Genomic_DNA.
DR AlphaFoldDB; G7N135; -.
DR HOGENOM; CLU_010702_0_0_1; -.
DR Proteomes; UP000013456; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 975..993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 709..753
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH19360.1"
FT NON_TER 1071
FT /evidence="ECO:0000313|EMBL:EHH19360.1"
SQ SEQUENCE 1071 AA; 120267 MW; A7B871F39C1AAB54 CRC64;
DGSRGSRPLA KGSREEVKAP RAGGSAAEDL RLPSTSFALT GDSAHNQAMV HWSGHNSSVI
LILTKLYDFN LGSVTESSLW RSTDYGTTYE KLNDKVGLKT VLSYLYVNPT NKRKIMLLSD
PEIESSILIS SDEGATYQKY RLTFYIQSLL FHPKQEDWVL AYSLDQKLYS SMDFGRRWQL
MHERITPNRF YWSVAGLDKE ADLVHMEVRT TDGYAHYLTC RIQECAETTR NGPFARSIDI
SSLVVQDEYI FIQVTTGGRA SYYVSYRREA FAQIKLPKYS LPKDMHIIST DENQVFAAVQ
EWNQNDTYNL YISDTRGIYF TLAMENIKSS RGLMGNIIIE LYEVAGIKGI FLANKKVDDQ
VKTYITYNKG RDWRLLQAPD VDLRGSPVHC LLPFCSLHLH LQLSENPYSS GRISSKETAP
GLVVATGNIG PELSYTDIGV FISSDGGNTW RQIFDEEYNV WFLDWGGALV AMKHTPLPVR
HLWVSFDEGH SWDKYGFTSV PLFVDGALVE AGMETHIMTV FGHFSLRSEW QLVKVDYKSI
FSRHCTKEDY QTWHLLNQGE PCVMGERKIF KKRKPGAQCA LGRDHSGSVV SEPCVCANWD
FECDYGYERH GESQCVPAFW YNPASPSKDC SLGQSYLNST GYRRIVSNNC TDGLREKYTA
KAQMCPGKAP RGLHVVTTDG RLVAEQGHNA TFIILMEEGD LQRTNIQLDF GDGIAVSYAN
FSPIEDGIKH VYKSAGIFQV TAYAENNLGS DTAVLFLHVV CPVEHVHLRV PFVAIRNKEV
NISAVVWPSQ LGTLTYFWWF GNSTKPLITL DSSISFTFVA EGTNTITVQV AAGNALIQDT
KEIAVHEYFQ SQLLSFSPNL DYHNPDIPEW RQDIGNVIKR ALVKVTSVPE DQILIAVFPG
LPTSAELFIL PPKNLTERRK GNEGDLEQIV ETLFNALNQN LVQFELKPGV QVIVYVTQLT
LAPLVDSSAG HSSSAMLMLL SVVFVGLAVF LIYKFKRKIP WINIYAQVQH DKEQEMIGSV
SQSENAPKIT LSDFTEPEEL LDKELDTRVI GGIATIANSE STKEIPNCTS V
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