ID   G7N3M0_MACMU            Unreviewed;       876 AA.
AC   G7N3M0;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   22-FEB-2023, entry version 34.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
DE   Flags: Fragment;
GN   ORFNames=EGK_02946 {ECO:0000313|EMBL:EHH20152.1};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH20152.1};
RN   [1] {ECO:0000313|EMBL:EHH20152.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CR-5 {ECO:0000313|EMBL:EHH20152.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM001262; EHH20152.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7N3M0; -.
DR   Proteomes; UP000013456; Chromosome 10.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13284; PH_OSBP_ORP4; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972:SF194; OXYSTEROL-BINDING PROTEIN 2; 1.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          141..233
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          348..375
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        60..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EHH20152.1"
FT   NON_TER         876
FT                   /evidence="ECO:0000313|EMBL:EHH20152.1"
SQ   SEQUENCE   876 AA;  97430 MW;  011E188EF9016E84 CRC64;
     STSGSGPEPK PQPQPVPEPE RGPLSEQVSE AVSEAVPRSE PVSETTSEPE PGAGQASELL
     QGSRPGSESS SGVGAGPFTK AASEPLSRSV GSAPFLRPES GSLPALKPLP LLRSGQAKTP
     LGVPMSGTGT TSSAPLALLP LDSFEGWLLK WTNYLKGYQR RWFVLGNGLL SYYRNQGEMA
     HTCRGTINLS TAHIDTEDSC GILLTSGARS YHLKAGSEVD RQQWITALEL AKAKAVRVMN
     THSDDSGDDD EATTPADKNE LHHTLKNLSL KLDDLSTCND LIAKHGAALQ RSLTELDGLK
     IPSESGEKLK VVNERATLFR ITSNAMINAC RDFLELAEIH SRKWQRALQY EQEQRVHLEE
     TIEQLAKQHN SLERAFRSAP GRPANPSKSF IEVSLHLGSH SQDEEDEDTE YFDAMEDSTS
     FITVITEAKE DSRKTEGSTG TSSVDWSSAD NVLDGASLVP KGSSKVKRRV RIPNKPNYSL
     NLWSIMKNCI GRELSRIPMP VNFNEPLSML QRLTEDLEYH HLLDKAVHCA SSVEQMCLVA
     AFSVSSYSTT VHRIAKPFNP MLGETFELDR LDDMGLRSLC EQVSHHPPSA AHYVFSKHGW
     SLWQEITISS KFRGKYISIM PLGAIHLEFQ ASGNHYVWRK STSTVHNIIV GKLWIDQSGD
     IEIVNHKTND RCQLKFLPYS YFSKEAARKV TGVVSDSQGK AHYVLSGSWD EQMECSKVVH
     SSPSSPSSDG KQKTVYQTLS AKLLWKKYPL PENAENMYYF SELALTLNEH EEGVAPTDSR
     LRPDQRLMEK GCWDEANTEK QRLEEKQRLS RRRRLEACGP GSSCSSEEAE KEADAYTPLW
     FEKRLDPLTG EMACVYKGGY WEAKEKQDWH MCPNIF
//