ID   G7N7H9_MACMU            Unreviewed;       821 AA.
AC   G7N7H9;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=p92 {ECO:0000313|EMBL:EHH20914.1};
GN   ORFNames=EGK_03860 {ECO:0000313|EMBL:EHH20914.1};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH20914.1};
RN   [1] {ECO:0000313|EMBL:EHH20914.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CR-5 {ECO:0000313|EMBL:EHH20914.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC       {ECO:0000256|ARBA:ARBA00008418}.
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DR   EMBL; CM001263; EHH20914.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7N7H9; -.
DR   Proteomes; UP000013456; Chromosome 11.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR   CDD; cd11290; gelsolin_S1_like; 1.
DR   CDD; cd11289; gelsolin_S2_like; 1.
DR   CDD; cd11292; gelsolin_S3_like; 1.
DR   CDD; cd11293; gelsolin_S4_like; 1.
DR   CDD; cd11288; gelsolin_S5_like; 1.
DR   CDD; cd11291; gelsolin_S6_like; 1.
DR   Gene3D; 3.40.20.10; Severin; 6.
DR   Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR036180; Gelsolin-like_dom_sf.
DR   InterPro; IPR007122; Villin/Gelsolin.
DR   InterPro; IPR003128; Villin_headpiece.
DR   InterPro; IPR036886; Villin_headpiece_dom_sf.
DR   PANTHER; PTHR11977:SF33; ADVILLIN; 1.
DR   PANTHER; PTHR11977; VILLIN; 1.
DR   Pfam; PF00626; Gelsolin; 6.
DR   Pfam; PF02209; VHP; 1.
DR   PRINTS; PR00597; GELSOLIN.
DR   SMART; SM00262; GEL; 6.
DR   SMART; SM00153; VHP; 1.
DR   SUPFAM; SSF55753; Actin depolymerizing proteins; 4.
DR   SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 2.
DR   SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR   PROSITE; PS51089; HP; 1.
PE   3: Inferred from homology;
KW   Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203}.
FT   DOMAIN          755..821
FT                   /note="HP"
FT                   /evidence="ECO:0000259|PROSITE:PS51089"
SQ   SEQUENCE   821 AA;  91913 MW;  A596FBF5CB51C69C CRC64;
     MSLTSAFRAV DNDPGIIVWR IEKMELALVP VRAHGNFYEG DCYVILSTRR VASLLSQDIH
     FWIGKDSSQD EQSCAAIYTT QLDDYLGGSP VQHRETVPTH YQKVTHPVYF GCSLSYKKGG
     VASGMKHVET NTYNMKRLLH VKGKRNIRAT EVEMSWDSFN RGDVFLLDLG KVIIQWNGPE
     SNSGERLKAM LLAKDIRDRE RGGRAEIGVI EGDKEAASPE LMKVLQDTLG RRSIIKPAVP
     DEIIDQQQKS NIMLYHVSDS PGQLAVTEVA TRPLVQDLLN HDDCYILDQS GTKIYVWKGK
     GATKAEKQAA MSKALGFIKM KGYPSSTNVE TVNDGAESAM FKQLFQKWSV KDQTMGLGKT
     FSIGKIAKVF QDKFDVTLLH TKPEVAAQER MVDDGSGKVE VWRIENLELV PVEYQWYGFF
     YGGDCYLVLY TYEVNGKPHH ILYIWQGRHA SQDELAASAY QAVEVDRQFD GAAVQVRVRM
     GTEPRHFMAI FKGKLVIFEG GTSRKGNAEP DPPVRLFQIH GNDKSNTKAV EVPAFASSLN
     SNDVFLLRTQ AEHYLWYGKG SSGDERAMAK ELASLLCDGS ENTVAEGQES AEFWDLLGGK
     TPYASDKRLQ QEILDVQSRL FECSNKTGQF IVTEITDFTQ DDLNPGDVML LDTWDQVFLW
     IGAEANATEK KSALATAQQY LLTHPSGRDP DTPILIIKQG SEPPIFTGWF LAWDPNIWSA
     GKSYEQLKEE LGDAAAIMQI TADMKNATLS VNSIDSESKY YPIAVLLKNQ NQELPEDVNP
     AKKENYLSEQ DFVSVFGITR GQFAALPGWK QLQMKKEKGL F
//