ID G7NFK7_MACMU Unreviewed; 598 AA.
AC G7NFK7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Mitoguardin 2 {ECO:0000256|ARBA:ARBA00040959};
DE AltName: Full=Protein FAM73B {ECO:0000256|ARBA:ARBA00041863};
GN ORFNames=EGK_07295 {ECO:0000313|EMBL:EHH23756.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH23756.1};
RN [1] {ECO:0000313|EMBL:EHH23756.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH23756.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
CC -!- SIMILARITY: Belongs to the mitoguardin family.
CC {ECO:0000256|ARBA:ARBA00008969}.
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DR EMBL; CM001267; EHH23756.1; -; Genomic_DNA.
DR AlphaFoldDB; G7NFK7; -.
DR Proteomes; UP000013456; Chromosome 15.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008053; P:mitochondrial fusion; IEA:InterPro.
DR InterPro; IPR019392; Miga.
DR PANTHER; PTHR21508; MITOGUARDIN; 1.
DR PANTHER; PTHR21508:SF4; MITOGUARDIN 2; 1.
DR Pfam; PF10265; Miga; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REGION 166..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 64939 MW; 623E110A1D70B50E CRC64;
MEGAGVLAVS SARGYLALWR GPLVCVFLSF WGVDGAQDPA SNQLKTFSLE ALGPEDFAWG
IGPAMAFRRA EGTSMIQALA MTVAEIPVFL YTTFGQSAFS QLRLTPGLRK VLFATALGTV
ALALAAHQLK RRRRRKKQAG PEMGGEQLGT VPLPILLARK VPSVKKGYSG RRVQSPSSKS
NDTLSGISSI EPSKHSGSSH SVASMVAVNS SSPTAACSGP WDARGMEESL TTSDGNAESL
YMQGMELFEE ALQKWEQALS VGQRGDSGST PTPRDGLRNP ETASEPLSEP ESQRKEFAEK
LESLLHRAYH LQEEFGSTFP ADSMLLDLER TLMLPLTEGS LRLRADDEDS LTSEDSFFSA
TELFESLQTG DYPIPLSRPA AAYEEALQLV KEGKVLCRTL RTELLGCYSD QDFLAKLHCV
RQAFEGLLED KSNQLFFGKV GRQMVTGLMT KAEKSPKGFL ESYEEMLSYA LQPETWATTR
LELEGRGVVC MSFFDIVLDF ILMDAFEDLE NPPASVLAVL RNRWLSDSFK ETVGRCPAPR
PTLAHISPCG CLAPFPLSLA LAPGLGPHPL DPGLPGLGDR SLLWRSLQGA PLLPGAPV
//
