ID G7NG86_MACMU Unreviewed; 840 AA.
AC G7NG86;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Very low-density lipoprotein receptor {ECO:0000313|EMBL:EHH24140.1};
DE Flags: Fragment;
GN ORFNames=EGK_07743 {ECO:0000313|EMBL:EHH24140.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH24140.1};
RN [1] {ECO:0000313|EMBL:EHH24140.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH24140.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CM001267; EHH24140.1; -; Genomic_DNA.
DR AlphaFoldDB; G7NG86; -.
DR Proteomes; UP000013456; Chromosome 15.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 8.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipoprotein {ECO:0000313|EMBL:EHH24140.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EHH24140.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 765..786
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 363..398
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 448..491
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 492..534
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 535..578
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 579..623
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 6..18
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 13..31
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 25..40
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 45..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 52..70
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 107..122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 127..139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 134..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 146..161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 166..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 173..191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 212..224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 219..237
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 245..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 252..270
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 264..279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 293..311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 367..377
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH24140.1"
FT NON_TER 840
FT /evidence="ECO:0000313|EMBL:EHH24140.1"
SQ SEQUENCE 840 AA; 92694 MW; 68169D80CA5ED3B3 CRC64;
GRKAKCEPSQ FQCTNGRCIT LLWKCDGDED CVDGSDEKNC VKKTCAESDF VCNNGQCVPN
RWKCDGDPDC EDGSDESPEQ CHMRTCRINE ISCAAHSTQC IPVSWRCDGE NDCDSGEDEE
NCGNITCSPS EFTCSSGRCI SRNFVCNGQD DCSDGSDELD CAPPTCGVHE FQCSTSSCIP
ISWVCDDDAD CSDQSDESLE QCGRQPVIHT KCPASEIQCG SGECIHKKWR CDGDPDCKDG
TSRTCRPDQF ECEDGSCIHG SRQCNGIRDC VDGSDEVNCK NVNQCLGPGK FKCRSGECID
ISKVCNQEQD CRDWSDEPLK ECHINECLVN NGGCSHICKD LVIGYECDCA AGFELIDRKT
CGDIDECQNP GICSQICINL KGGYKCECSR GYQMDLATGV CKAVGKEPSL IFTNRRDIRK
IGLERKEYIQ LVEQLRNTVA LDADIAAQKL FWADLSQKAI FSASIDDKVG RHVKMIDNVY
NPAAIAVDWV YKTIYWTDAA SKTISVATLD GTKRKFLFNS DLREPASIAV DPLSGFVYWS
DWGEPAKIEK AGMNGFDRRP LVTVDIQWPN GITLDLIKSR LYWLDSKLHM LSSVDLNGQD
RRIVLKSLEF LAHPLALTIF EDRVYWIDGE NEAVYGANKF TGSELATLVN NLNDAQDIIV
YHELVQPSGK NWCEEDMENG GCEYLCLPAP QINDHSPKYT CSCPNGFNLE ENGRDCQSTA
TTVTYSETKD TNTTEISPTS GLVPGGINVT TAVSEVSVPP KGTSAAWAIL PLLLLVMAAV
GGYLMWRNWQ HKNMKSMNFD NPVYLKTTEE DLSIDIGRHS ASVGHTYPAI SVVSTDDDLA
//
