ID G7NI96_MACMU Unreviewed; 450 AA.
AC G7NI96;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Keratin, type I cytoskeletal 25 {ECO:0000256|ARBA:ARBA00040316};
DE AltName: Full=Cytokeratin-25 {ECO:0000256|ARBA:ARBA00041715};
DE AltName: Full=Keratin-25 {ECO:0000256|ARBA:ARBA00042483};
DE AltName: Full=Type I inner root sheath-specific keratin-K25irs1 {ECO:0000256|ARBA:ARBA00043217};
GN ORFNames=EGK_08663 {ECO:0000313|EMBL:EHH24922.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH24922.1};
RN [1] {ECO:0000313|EMBL:EHH24922.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH24922.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CM001268; EHH24922.1; -; Genomic_DNA.
DR AlphaFoldDB; G7NI96; -.
DR Proteomes; UP000013456; Chromosome 16.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF160; KERATIN, TYPE I CYTOSKELETAL 25; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754}.
FT DOMAIN 79..394
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 83..117
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 252..358
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 450 AA; 49102 MW; 9DCEBFC490EED041 CRC64;
MSLRLSSASR RSCPRPTTGS LRLSGGGTSF GAGNACGISG IGSSFSCALG GSSSGGNAAG
GNPCAGFTVN EGGLLSGNEK VTMQNLNDRL ASYLDNVRAL EEANADLEQK IKGWYEKFGP
GSCRGLDHDY SRYFPIIDDL KNQIIASTTS NANAVLQIDN ARLTADDFRL KYENELALHQ
SVEADVNGLR RVLDEITLCR TDLEIQYETL SEEMTYLKKN HKEEMQVLQC AAGGNVNVEM
NAAPGVDLTV LLNNMRAEYE ALAEQNRRDA EAWFNEKSAS LQQQISEDVG ATTSARNELT
EMKRTLQTLE IELQSLLATK RSLEGSLTET ESNYCAQLAQ IQAQIGALEE QLHQVRTETE
GQKLEYEQLL DIKLHLEKEI ETYCLLIGGD DGACKSGGYK SKDYGSGNVG SQVKDSAKAI
VVKKVLEEVD QRSKILTTRL HSLEEKSQSN
//
