ID G7NJ68_MACMU Unreviewed; 357 AA.
AC G7NJ68;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=tRNA N(3)-methylcytidine methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037755};
GN ORFNames=EGK_08852 {ECO:0000313|EMBL:EHH25090.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH25090.1};
RN [1] {ECO:0000313|EMBL:EHH25090.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH25090.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase.
CC {ECO:0000256|PIRNR:PIRNR037755}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC {ECO:0000256|PIRNR:PIRNR037755}.
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DR EMBL; CM001268; EHH25090.1; -; Genomic_DNA.
DR AlphaFoldDB; G7NJ68; -.
DR Proteomes; UP000013456; Chromosome 16.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR026113; METTL2/6/8-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22809:SF4; TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2A; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR PIRSF; PIRSF037755; Mettl2_prd; 4.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
KW Transferase {ECO:0000256|PIRNR:PIRNR037755}.
FT DOMAIN 247..290
FT /note="Methyltransferase type 11"
FT /evidence="ECO:0000259|Pfam:PF08241"
SQ SEQUENCE 357 AA; 41327 MW; 0D3061C7EA48EDA4 CRC64;
MAGTREAELA IQRLLEEGVA RSKFSRYRKL SVSGSGVMAG SYPEGAPAVL ADKRQQFGNR
FLSDPARVFH HNAWDNVEWS EEQAAAAERK VQENSTQRVC QEKQVDYEIN AHKYWNNFYK
IHENGFFKDR HWLFTEFPEL APSQNQNHLK DWFLENKRSE VPECRNNEDG PSLIMEEQHK
CSSKSLEHKT ETPPVEENVT QKISDLEICA DEFPGSSATY RILETNPEYD PSRCFAFVHD
LCDEEKSYPV PKGSLDIIIL IFVLSAIVPD KMQKAINRLS RLLKPGGMML LRDYGRYDMA
QLRFKKEELD MLFTTAGLEK VQNLVDRRLQ VNRGKQLTMY RVWIQCKYCK PLLSSTS
//
