ID G7NQ24_MACMU Unreviewed; 1940 AA.
AC G7NQ24;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Trinucleotide repeat containing adaptor 6A {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGK_12611 {ECO:0000313|EMBL:EHH31522.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH31522.1};
RN [1] {ECO:0000313|EMBL:EHH31522.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH31522.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SIMILARITY: Belongs to the GW182 family.
CC {ECO:0000256|ARBA:ARBA00007302}.
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DR EMBL; CM001272; EHH31522.1; -; Genomic_DNA.
DR Proteomes; UP000013456; Chromosome 20.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd12711; RRM_TNRC6A; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR019486; Argonaute_hook_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR032226; TNRC6_PABC-bd.
DR InterPro; IPR034924; TNRC6A_RRM.
DR PANTHER; PTHR13020; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6; 1.
DR PANTHER; PTHR13020:SF28; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6A PROTEIN; 1.
DR Pfam; PF10427; Ago_hook; 1.
DR Pfam; PF16608; TNRC6-PABC_bdg; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 1049..1178
FT /note="Argonaute hook"
FT /evidence="ECO:0000259|Pfam:PF10427"
FT DOMAIN 1483..1756
FT /note="TNRC6 PABC binding"
FT /evidence="ECO:0000259|Pfam:PF16608"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1227..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1301..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1402..1434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1556..1613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1702..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 989..1035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1301..1343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1704..1718
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1940 AA; 207613 MW; 394ED5E6F55B5306 CRC64;
MEEKKKKKDD KKKKEAAQKK ATEQKIKVMF STPFLLLGLV PEQIKPSVSQ PQPANSNNGT
STATSTNNNA KRATANNQQP QQQPQQQQQQ PQQQPQPQQP QQQPQALPRY PREVPPRFRH
QEHKQLLKRG QHFPVIAANL GSAVKVLNSQ SESSALTNQQ PQNNGEVQNS KNQSDINHST
SGSHYENSQR GLVSSTSDSS TNCKNAVVSD LSEKEAWPSV PGSDPELASE CMDADSASSS
ESERNITIMA SGNTGGEKDG LRNSTGLGSQ NKFVVGSSSN NVGHGSSTGP WGFSHGAIIS
TCQVSVDAPE SKSESSNNRM NAWGTVSSSS NGGLNPSTLN SASNHGAWPV LENNGLALKG
PVGSGSSGIN IQCSTIGQMP NNQSINSKVS GGSTHGTWGS LQETCESEVS GTQKVSFSGQ
PQNITTEMTG PNNTTNFMTS SLPNSGSVQN NELPSSNTGA WRVSTMNHPQ MQAPSGMNGT
SRSHLSNGES KSGGSYGTTW GAYGSNYSGD KCSGPNGQAN GDTVNATLMQ PGVNGPMGTN
FQVNTNKGGG VWESGAANSQ SASWGSGNGA NSGGSRRGWG TPAQNTGTNL PSGEWNKLPS
NQHSNDSANG NGKKFTNGWK STEEEDQGSA TSQTNEQSSV WAKTGATVES DGSTESTGRL
EEKGTGESQS RDRRKIDQHT LLQSIVNRTD LDPRVLSNSG WGQTPIKQNT AWDTETSPRG
ERKTDNGTEA WGSSATQTFN SGACIDKTSP NSNDTSSVSG WGDPKPALRW GDSKGSNCQG
GWEDDSAATG MVKSNQWGNC KEEKAAWNDS QKNKQGWGDG QKSSQGWSVS ASDSWGETSR
SNHWGEANKK SSSGGSDSDR SVSGWNELGK TSSFTWGNNI NPNNSSGWDE SSKPTPSQGW
GDPPKSNQSL GWGDSSKPVS SPDWNKQQDI VGSWGIPPAT GKPPGTGWLG GPIPAPTKEE
EPTGWEEPSP ESIRRKMEID DGTSAWGDPS KYNYKNVNMW NKNVPNGNSR SDQQAQVHQL
LTPASAISNK EASSGSGWGE PWGEPSTPAT TVDNGTSAWG KPIDSGPSWG EPIAAASSTS
TWGSSSVGPQ ALSKSGPKSM QDGWCGDDMP LPGNRPTGWE EEEDVEIGMW NSNSSQELNS
SLNWPPYTKK MSSKGLSGKK RRRERGMMKG GNKQEEAWIN PFVKQFSNIS FSRDSPEENV
QSNKMDLSGG MLQDKRMEID KHSLNIGDYN RTVGKGPGSR PQISKESSME RNPYFDKDGI
VADESQNMQF MSSQSMKLPP SNSALPNQAL GSIAGLGMQN LNSVRQNGNP SMFGVGNTAA
QPRGMQQPPA QPLSSSQPNL RAQVPPPLLS PQVPVSLLKY APNNGGLNPL FGPQQVAMLN
QLSQLNQLSQ ISQLQRLLAQ QQRAQNQRSV PSGNRPQQDQ QGRPLSVQQQ MMQQSRQLDP
NLLVKQQTPP SQQQPLHQPA MKSFLDNVMP HTTPELQKGP SPINAFSNFP IGLNSNLNVN
MDMNSIKEPQ SRLRKWTTVD SISVNTSLDQ NSSKHGAISS GFRLEESPFV PYDFMNSSTS
PASPPGSIGD GWPRAKSPNG SSSVNWPPEF RPGEPWKGYP NIDPETDPYV TPGSVINNLS
INTVREVDHL RDRNSGSSSS LNTTLPSTSA WSSIRASNYN VPLSSTAQST SARNSDSKLT
WSPGSVTNTS LAHELWKVPL PPKNITAPSR PPPGLTGQKP PLSTWDNSPL RVGGGWGNSD
ARYTPGSSWG ESSSGRITNW LVLKNLTPQI DGSTLRTLCM QHGPLITFHL NLPHGNALVR
YSSKEEVVKA QKSLHMCVLG NTTILAEFAS EEEISRFFAQ SQSLTPSPGW QSLGSSQSRL
GSLDCSHSFS SRTDLNHWNG AGLSGTNCGD LHGTSLWGTP HYSTSLWGPP SSSDPRGISS
PSPINAFLSV DHLGGGGESM
//
