ID G7NQU9_MACMU Unreviewed; 3789 AA.
AC G7NQU9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Autosomal dominant polycystic kidney disease 1 protein {ECO:0000313|EMBL:EHH31323.1};
DE Flags: Fragment;
GN ORFNames=EGK_12374 {ECO:0000313|EMBL:EHH31323.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH31323.1};
RN [1] {ECO:0000313|EMBL:EHH31323.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH31323.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; CM001272; EHH31323.1; -; Genomic_DNA.
DR Proteomes; UP000013456; Chromosome 20.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0001822; P:kidney development; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd00146; PKD; 14.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000434; PC1.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR006228; Polycystin_cat.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR NCBIfam; TIGR00864; PCC; 1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR PANTHER; PTHR46730:SF3; POLYCYSTIN-1; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00801; PKD; 14.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR Pfam; PF01822; WSC; 1.
DR PRINTS; PR00500; POLYCYSTIN1.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SMART; SM00369; LRR_TYP; 1.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00089; PKD; 15.
DR SMART; SM00321; WSC; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF49299; PKD domain; 13.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50093; PKD; 12.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
DR PROSITE; PS51212; WSC; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2998..3018
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3204..3225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3245..3267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3478..3500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3506..3525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3593..3612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..199
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 227..287
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 343..459
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 884..946
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 976..1055
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1053..1141
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1162..1219
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1244..1309
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1335..1395
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1413..1477
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1499..1561
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1645..1731
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1757..1816
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2005..2074
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2072..2759
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 3041..3156
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 3354..3388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH31323.1"
FT NON_TER 3789
FT /evidence="ECO:0000313|EMBL:EHH31323.1"
SQ SEQUENCE 3789 AA; 407318 MW; D2D27B1886419C53 CRC64;
DVSHNLLRAL DVGLLANLSQ LSELDISNNK ISTLEEGIFA NLFNLSEINL SGNPFECDCG
LVWLPRWAEE QQVRVVQPEA ATCAGPGSLA GQPLLGIPLL DSDCGEEYIA CLPDNSSGTV
AAVAFSAAHE GLLQPEACSA FCFSTGRGLA ALSEQGWCLC GAAQPSSASF ACLSFCSGPP
PPPALDCGGP TLLQHVFPAS PGAALVGPHG PLASGQLAAF HIAAPLPVTA TRWDFGDGSP
EVDAAGPAAS HRYVLPGRYH VTAVVALGVS SALLGTNVQV EAAPAALELV CPSSVQSDES
LKLSIQNRGG SGLEAAYSIV ALGEELARVV HPLCPSDTEI FPGNGHCYRL VVEKAAWLQA
QEQCRAWAGA ALAMVDSPAV QRFLVSRVTR SLDVWIGFST VQGAETGLAP QGEAFSLESC
QNWLPGEPHP ATAEHCVRLG PTGWCNTDLC SAPHSYVCEL RPGGPVQDAE NLLVGAPSGD
LQGPLTPLTP QDGLSAPHEP VEVMVFPGLS LSHEAFLTTA EFGTQELRRP AQLRLQVYRL
LSTAGTPENG SEPESRSPDN RTQLVPECMP GGRWCPAANV CVPLDASCHP QANGCTSGPG
LPGALYALWR EFLFSVPAGP PAQYSVTLHG QDVLMLPGDL VGLQHDAGPG ALLHCSPAPG
HPGPQALYLS ANASAWLPHL PAQLEGTRDC PACALRLLAA TEQLTVLLGL RPNPGLRLPG
HYEVRAEVGN GVSRHNLSCS FNVVSPVAGL RVIYPAPHNG HLYVPTNGSA LVLQVDSGAN
ATATARWPGG NVSTRFEAAC PALVATLLPG CPWETNDTQF SVVALPWLSE GEHVVEVVAE
NSASQANLSL RVTAEEPICG LRATPSPEAR VLQGVLVRYS PVVEAGSDVV FRWTINDKQS
LTFQNVVFNV IYQSAAVFKL SLTASNHVSN VTVNYNVTVE RMNRMQGLWV STVPAVLPPN
ATLALTAGVL VDSAVEVAFL WTFGDGEQAL RQFHPPYNES FPVPDPSVAQ VLVEHNVTHT
YAAPGEYILT VLTSNAFENL TQQVPVSVRA ALPSMAVGVS DSVLVAGRPI TFYPHPLPSP
GGVLYTWDFG DSSPVLTQSQ PTANHTYASR GTYRVHLEVN NTVSSALAQA DVRVFEELRG
LSVNMSLAVE QGAPVVVSAA VQTGDDITWT FDMGDGTVLS GPEDTVEHVY LRAQNCTVTV
GAASPAGRLA QSLHVLVFVL EVLRIEPAAC IPTQPDARLT AYVTGNPAHY LFDWTFGDGS
SNTTVRGRPT VTHNFTRSGT FPLALVLSSP VNKAHYFTSI CVEPEVGNVT LQPERQFVQL
GDEVRLVACV WPPFPYRYAW DFGTEEAAPA RAGGPEVTFT YRDPGSYLVT VTVSNNVSAA
NDSALVEVQE PVVVTDIKVN SSLVLELQQP YLFSAVGRGR PASYLWDLGD GGRLEGPEVT
HAYNSIGDFT VRVAGWNDVS RSEAWLNVTV KRRVRGLVVN ASRTVVPLNG SVSFSTSLEA
GSDVRYSWVL CDRCTPIPGG PTISYTFRSV GTFSIIVTAE NEVGSAQDSI FVYVLQLIEG
LQVAGCGSYF PTNHTAQLQA VVRDGTNVSY SWTAWWDRGP ALAGSGKGFS LTALEAGTYH
VQLRATNMLG SAWADCTVDF VEPVGWLMVT ASPNPAAVNT SVTLSAKLAG GSGVLYTWSL
EEGLSWETPE PFTTHSFPTP GLHLVTVTAG NPLGSASATV EVGVQVPVSG LSIRASESGG
SFVAAGSSVP FWGQLATGTN VSWCWAVPGG SSKRGPHVTM VFPDAGTFSV QLNASNAVSW
VSATHNLTVE EPIVGLVLWA SSKVVAPGQL VHFQILLAAG SAVTFRLQVG GASPAVLPGP
RFSHSFPRVG DHVVSVQGEN HVSWAQAQVR IVVLEAVSGL QVPNCCEPGI ATGTERNFTA
RVQRGSRVAY AWYFSLQKVQ GDSLVILSGR DVTYTPVAAG LLEIQVRAFN ALGSENRTLV
LEVQDAVQYV ALRSGPCFTN RSAWFEAATS PSPRRVAYHW DFGDGAPGQD TDEPRAEHCY
LRPGDYRVQV NASNLVSFFV AQATVTVQVL ACREPEVDVV LPLQVLMRRS QRNYLEAHVD
LRDCVTYQTE YRWEVYRTAS CQRPGRPTRV ALPGVDVSRP QLVLPRLALP VGHYCFVFVV
SFGDTPLARS IQANVTVAPE RLVPIIEGGS YRVWSDTQDL VLDGSESYDP NLEDGDQTPL
SFHWACVAST QREAGGCALN FGPRGSSVVT IPRERLAAGV EYTFSLTVWK AGRKEEATNQ
TVLIRRGRVP IVSLECVSCK AQAVYEVSRS SYVYLEGRCL NCSSGSKRGR WAARTFSNKT
LVLDETTTST GSAGMRLVLR RGVLRDGEGY TFTLTVLGHS GEEEGCASIR LSPNRPPLGG
SCRLFPLGNV HALTTKVHFE CTGWHDAEDA GAPLVYALLL RRCRQGHCEE FCVYKGSLSS
YGAVLPPGFR PHFEVGLAVV VQDQLGAAVV ALNRSLAIAL PEPSGGTTGL TVWLHGLTAS
VLPGLLRQAD PQHVIEYSLA LVTVLNEYEQ ALDVAAEPEH ERQRRAQIRK NVTQTLVSLR
VHTVDDIQQI AAALAQSMGP SRELVCRSCL KQTLHKLEAM MRILQAETTA GTVTPTAIGD
SILNITGDLI HLASSDVWGP QPSELGAESP SRMVASQAYN LTSALMRILM RSRVLNEEPL
TLAGEEIVAQ GKRSDPRSLL CYGGAPGPGC HFSIPEAFSG ALANLSDVVQ LIFLVDSNPF
PFGYISNYTV STKVASMAFQ TQAGAQIPIE RLASERAITV KVPNNSDWAA RGHRSSADSV
VVQPQASVSA VVTLDSSNPA AGLHLQLNYT LLDGRYLSEE PEPYLAVYLH SEPRPNEHNC
SASRRIRPES LEGADHRPYT FFIAPGTGDQ AGSYHLNLTS HFRWSALKVS VGLYTSLCQY
FSEENMVWRT EGLLPLEETS PHQAVCLTRH LTAFGASLFV PPSHVHFVFP EPTAGVNYIV
MLTCAVCLVT YAVMAAILHK LDQLDASRGR AIPFCGQRGR FKYEILVKTG WGRGSGTTAH
VGIMLYGVDS RSGHRHLDGD RAFHRNSLDI FQIATPHSLG SVWKIRVWHD NKGLSPAWFL
QHVIVRDLQT ARSAFFLVND WLSVETEANG GLVEKEVLVA SDAALLRFRR LLVAELQRGF
FDKHIWLSIW DRPPRSRFTR IQRATCCVVL ICLFLGANAV WYGAVGDSTY SAGRVSRLRP
LSVDTVAVGL VSSVIVYPIY LAVLFLFRMS RSKVAGGLSP TPARQQVLDI DSCLDSSVLD
SSFLTFSGLH AEQAFAGQMK SDLFLDDSKS LVCWPSSEGT LSWPDLLSDP SIVGSNPRQL
ARGQAGHGLG PEEDSFSLAS PYSPAKSSAS DEDLIQQVLA KGVSSPAPTQ DTHMETDLLT
SLSSTPGEKT ETLELQRLGE LGPPSPGLTW ERPQAARLSR TGLVEGPRKR LLPAWCTSLA
HGLSLLLVAV AVAVSGWVGV GFPPGVSVAW LLSSTTSFLA SFLGWEPLKV LLEALYFSLV
AKRLHPDEDD TLVESPAVTP VCARVPRVRP PHGFALFLAK EEARKVKRLH GMLRSLLVYM
LFLLVTLLAS YGDASCHGHA YRLQSAIKQE LHSRTFLAIT RSEELWPWMA HVLLPYVHGN
QSSPELGPPR LRQVRLQEAL CPDPPGPRVH TCSAAGGFST SDYDVGWESP HNGSGTWAYS
APDLLGAWSW GSCAVYDSGG YVQELGLSLE ESRDRLRFLQ LHNWLDNRSR AVFVELTRYS
PAVGLHAAV
//
