ID G7NTP3_MACFA Unreviewed; 825 AA.
AC G7NTP3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 13-SEP-2023, entry version 36.
DE RecName: Full=Breast cancer anti-estrogen resistance protein 3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGM_00847 {ECO:0000313|EMBL:EHH50080.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH50080.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH50080.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; CM001276; EHH50080.1; -; Genomic_DNA.
DR AlphaFoldDB; G7NTP3; -.
DR Proteomes; UP000009130; Chromosome 1.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 154..253
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 548..818
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 31..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 92639 MW; 9C3DD9191B37731A CRC64;
MAAGKFASLP RNMPVNHQFP LASSMDLLSS KSPLTEHRPD AYQDVSIHGT LPRKKKGPPP
IRSCDDFSHM GTLPHSKSPR QNSPVTQDSI QESPWQDRHC ETFTFRDPHL LDPTLEYVKF
SKERHIMDRT PEKLKKELEE ELLLSSEDLR SHAWYHGRIP RQVSENLVQR DGDFLVRDSL
SSPGNFVLTC QWKNLAQHFK INRTVLRLSE AYSRVQYQFE MESFDSIPGL VRCYVGNRRP
ISQQSGAIIF QPINRTVPLR CLEERYGISP GQAREGSLTE GRPDVTKRMS LTMGGVQARE
QNLPRGNLLR NKEKSGSQPA CLDHMQDRRA LSLKAHQSES YLPIGCKLPP QSSGVDTSPC
PNSPVFRTGS EPALSPAVVR RVSSDARAGE ALRGSDSQLC PKPPPKPCKV PFLKAPSSPS
AWLNSEANYC ELNPAFATGC GRGAKLPLCA QGSPTELLTA KQNGALGPRN SGINYLILDD
DDRERPWEPA AAQTEKGQWD KGEFVAPLLE TVSSFRPNDF ESKFLPPENK PLETAMLKRA
KELFTNNDPK VIAQHILSMD CRVARILEVS EEMRRNMGVS SGLELITLPH GHQLRLDIIE
RHSTMAIGIA VYILGCTGTL EDRAATLSKV IQVAVELKDS MGDLYSFSAL MKALEMPQIT
RLEKTWTALR HQYTQTAILY EKQLKPFSKI LHEGRESTCV PPNNVSVPLL MPLVTLMERQ
AVTFEGTDMW EKNDQSCEIM LNHLATARLM AEATDSYRMN AERILAGFQP DEEMNEICKT
EFQMRLLWGS KGAQVNQAER YEKFNQILTA LSRKLEPPPV KQAEL
//