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Database: UniProt
Entry: G7NTP3_MACFA
LinkDB: G7NTP3_MACFA
Original site: G7NTP3_MACFA 
ID   G7NTP3_MACFA            Unreviewed;       825 AA.
AC   G7NTP3;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   13-SEP-2023, entry version 36.
DE   RecName: Full=Breast cancer anti-estrogen resistance protein 3 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=EGM_00847 {ECO:0000313|EMBL:EHH50080.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1] {ECO:0000313|EMBL:EHH50080.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH50080.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
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DR   EMBL; CM001276; EHH50080.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7NTP3; -.
DR   Proteomes; UP000009130; Chromosome 1.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd10337; SH2_BCAR3; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR   PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR   PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00017; SH2; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          154..253
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          548..818
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          31..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   825 AA;  92639 MW;  9C3DD9191B37731A CRC64;
     MAAGKFASLP RNMPVNHQFP LASSMDLLSS KSPLTEHRPD AYQDVSIHGT LPRKKKGPPP
     IRSCDDFSHM GTLPHSKSPR QNSPVTQDSI QESPWQDRHC ETFTFRDPHL LDPTLEYVKF
     SKERHIMDRT PEKLKKELEE ELLLSSEDLR SHAWYHGRIP RQVSENLVQR DGDFLVRDSL
     SSPGNFVLTC QWKNLAQHFK INRTVLRLSE AYSRVQYQFE MESFDSIPGL VRCYVGNRRP
     ISQQSGAIIF QPINRTVPLR CLEERYGISP GQAREGSLTE GRPDVTKRMS LTMGGVQARE
     QNLPRGNLLR NKEKSGSQPA CLDHMQDRRA LSLKAHQSES YLPIGCKLPP QSSGVDTSPC
     PNSPVFRTGS EPALSPAVVR RVSSDARAGE ALRGSDSQLC PKPPPKPCKV PFLKAPSSPS
     AWLNSEANYC ELNPAFATGC GRGAKLPLCA QGSPTELLTA KQNGALGPRN SGINYLILDD
     DDRERPWEPA AAQTEKGQWD KGEFVAPLLE TVSSFRPNDF ESKFLPPENK PLETAMLKRA
     KELFTNNDPK VIAQHILSMD CRVARILEVS EEMRRNMGVS SGLELITLPH GHQLRLDIIE
     RHSTMAIGIA VYILGCTGTL EDRAATLSKV IQVAVELKDS MGDLYSFSAL MKALEMPQIT
     RLEKTWTALR HQYTQTAILY EKQLKPFSKI LHEGRESTCV PPNNVSVPLL MPLVTLMERQ
     AVTFEGTDMW EKNDQSCEIM LNHLATARLM AEATDSYRMN AERILAGFQP DEEMNEICKT
     EFQMRLLWGS KGAQVNQAER YEKFNQILTA LSRKLEPPPV KQAEL
//
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