GenomeNet

Database: UniProt
Entry: G7NWN3_MACFA
LinkDB: G7NWN3_MACFA
Original site: G7NWN3_MACFA 
ID   G7NWN3_MACFA            Unreviewed;      4951 AA.
AC   G7NWN3;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   22-NOV-2017, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH50900.1};
GN   ORFNames=EGM_01799 {ECO:0000313|EMBL:EHH50900.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH50900.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH50900.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CM001276; EHH50900.1; -; Genomic_DNA.
DR   Proteomes; UP000009130; Chromosome 1.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4264   4283       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4484   4504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4558   4577       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4694   4715       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4752   4773       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4828   4851       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    149       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      156    201       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      209    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    327       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      335    392       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      583    793       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1009   1206       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1321   1546       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4007   4042       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4396   4429       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4951 AA;  563135 MW;  66C0C44EBB5EDC73 CRC64;
     MMKWFCSAPQ PSTKNNRNYA WQQKDLATDF VSWSPLLIPR MCPQTSPSAP LCWSSPSLSG
     PCRRCWLTPW RNQKGQVDVE KWLFSLKTAQ GGGHRTLLYG HAILLRHSYS GMYLCCLSTS
     RSSTDKLAFD VGLQEDTTGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV SSERYLHLSY
     GNGSLHVDAA FQQTLWSVAP ISSGSEAAQG YLIGGDVLRL LHGHMDECLT VPSGEHGEEQ
     RRTVHYEGGA VSVHARSLWR LETLRVAWSG SHIRWGQPFR LRHVTTGKYL SLMEDKNLLL
     MDKEKADVKS TAFTFRSSKE KLDVGVRKEV DGMGTSEIKY GDSVCYIQHV DTGLWLTYQS
     VDVKSVRMGS IQRKAIMHHE GHMDDGISLS RSQHEESRTA RVIRSTVFLF NRFIRGLDAL
     SKKAKATTVD LPIESVSLSL QDLIGYFHPP DEHLEHEDKQ NRLRALKNRQ NLFQEEGMIN
     LVLECIDRLH VYSSAAHFAD VAGREAGESW KSILNSLYEL LAALIRGNRK NCAQFSGSLD
     WLISRLERLE ASSGILEVLH CVLVESPEAL NIIKEGHIKS IISLLDKHGR NHKVLDVLCS
     LCVCHGVAVR SNQHLICDNL LPGRDLLLQT RLVNHVSSMR PNIFLGVSEG SAQYKKWYYE
     LMVDHTEPFV TAEATHLRVG WASTEGYSPY PGGGEEWGGN GVGDDLFSYG FDGLHLWSGC
     IARTVSSPNQ HLLRTDDVIS CCLDLSAPSI SFRINGQPVQ GMFENFNIDG LFFPVVSFSA
     GIKVRFLLGG RHGEFKFLPP PGYAPCYEAV LPKEKLKVEH SREYKQERTY TRDLLGPTVS
     LTQAAFTPIP VDTSQIVLPP HLERIREKLA ENIHELWVMN KIELGWQYGP VRDDNKRQHP
     CLVEFSKLPE QERNYNLQMS LETLKTLLAL GCHVGISDEH AEDKVKKMKL PKNYQLTSGY
     KPAPMDLSFI KLTPSQEAMV DKLAENAHNV WARDRIRQGW TYGIQQDVKN RRNPRLVPYT
     LLDDRTKKSN KDSLREAVRT LLGYGYNLEA PDQDHAARAE VCSGTGERFR IFRAEKTYAV
     KAGRWYFEFE TVTAGDMRVG WSRPGCQPDQ ELGSDERAFA FDGFKAQRWH QGNEHYGRSW
     QAGDVVGCMV DMNEHTMMFT LNGEILLDDS GSELAFKDFD VGDGFIPVCS LGVAQVGRMN
     FGKDVSTLKY FTICGLQEGY EPFAVNTNRD ITMWLSKRLP QFLQVPSNHE HIEVTRIDGT
     IDSSPCLKVT QKSFGSQNSH TDIMFYRLSM PIECAEVFSK TVAGGLPGAG LFGPKNDLED
     YDADSDFEVL MKTAHGHLVP DRVDKDKEAT KPEFNNHKDY AQEKPSRLKQ RFLLRRTKPD
     YSTSHSARLT EDVLADDRDD YDFLMQTSTY YYSVRIFPGQ EPANVWVGWI TSDFHQYDTG
     FDLDRVRTVT VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE IGCVVDAASG
     LLTFIANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL SAGLFKSEHK
     NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG WLVQCLDPLQ FMSLHIPEEN
     RSVDILELTE QEELLKFHYH TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL YAIENKYMPG
     LLRAGYYDLL IDIHLSSYAT ARLMMNNEYI VPMTEETKSI TLFPDENKKH GLPGIGLSTS
     LRPRMQFSSP SFVSVSNECY QYSPEFPLDI LKAKTIQMLT EAVKEGSLHA RDPVGGTTEF
     LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAT PEEESDTLEK ELSVDDAKLQ
     GAGEEEAKGG KRPKEGLLQM KLPEPVKLQM CLLLQYLCDC QVRHRIEAIV AFSDDFVAKL
     QDNQRFRYNE VMQALNMSAA LTARKTKEFR SPPQEQINML LNFKDDKSEC PCPEEIRDQL
     LDFHEDLMTH CGIELDEDGS LDGNSDLTIR GRLLSLVEKV TYLKKKQAEK PVESDSKKSS
     TLQQLISETM VRWAQESVIE DPELVRAMFV LLHRQYDGIG GLVRALPKTY TINGVSVEDT
     INLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG MHETVMEVMV
     NVLGGGESKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS VGLASPAMRG
     STPLDVAAAS VMDNNELALA LREPDLEKVV RYLAGCGLQS CQLLVSKGYP DIGWNPVEGE
     RYLDFLRFAV FCNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAA MEEAIKIAED
     PSRDGPSPNS GSSKTLDTEE EEDDTIHMGN AIMTFYAALI DLLGRCAPEM HLIHAGKGEA
     IRIRSILRSL IPLGDLVGVI SIAFQMPTIA KDGNVVEPDM SAGFCPDHKA AMVLFLDRVY
     GIEVQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL NRYLCTAVLP LLTRCAPLFA
     GTEHHASLID SLLHTVYRLS KGCSLTKAQR DSIEVCLLSI CGQLRPSMMQ HLLRRLVFDV
     PLLNEHAKMP LKLLTNHYER CWKYYCLPGG WGNFGAASEE ELHLSRKLFW GIFDALSQKK
     YEQELFKLAL PCLSAVAGAL PPDYMESNYV SMMEKQSSMD SEGNFNPQPV DTSNITIPEK
     LEYFINKYAE HSHDKWSMDK LANGWIYGEI YSDSSKVQPL MKPYKLLSEK EKEIYRWPIK
     ESLKTMLAWG WRIERTREGD SMALYNRTRR ISQTSQVSVD AAHGYSPRAI DMSNVTLSRD
     LHAMAEMMAE NYHNIWAKKK KMELESKGGG NHPLLVPYDT LTAKEKAKDR EKAQDILKFL
     QINGYAVSRG FKDLELDTPS IEKRFAYSFL QQLIRYVDEA HQYILEFDGG SRGKGEHFPY
     EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA SNKEKEMVTS LFCKLGVLVR
     HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGLESVKSA LRAFLDNAAE DLEKTMENLK
     QGQFTHTRNQ PKGVTQIINY TTVALLPMLS SLFEHIGQHQ FGEDLILEDV QVSCYRILTS
     LYALGTSKSI YVERQRSALG ECLAAFAGAF PVAFLETHLD KHNIYSIYNT KSSRERAALS
     LPTNVEDVCP NIPSLEKLME EIVELAESGI RYTQMPHVME VILPMLCSYM SRWWEHGPEN
     NPERAEMCCT ALNSEHMNTL LGNILKIIYN NLGIDEGAWM KRLAVFSQPI INKVKPQLLK
     THFLPLMEKL KKKAAMVVSE EDHLKAEARG DMSEAELLIL DEFTTLARDL YAFYPLLIRF
     VDYNRAKWLK EPNPEAEELF RMVAEVFIYW SKSHNFKREE QNFVVQNEIN NMSFLITDTK
     SKMSKAAVSD QERKKMKRKG DRYSMQTSLI VAALKRLLPI GLNICAPGDQ ELIALAKNRF
     SLKDTEDEVR DIIRSNIHLQ GKLEDPAIRW QMALYKDLPN RTDDTSDPEK TVERVLDIAN
     VLFHLEQKSK RVGRRHYCLV EHPQRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRA
     VNLFLQGYEK SWIETEEHYF EDKLIEDLAK PGADPPEEDE GTKRVDPLHQ LILLFSRTAL
     TEKCKLEEDF LYMAYADIMA KSCHDEEDDD GEEEVKSFEE KEMEKQKLLY QQARLHDRGA
     AEMVLQTISA SKGETGPMVA ATLKLGIAIL NGGNSTVQQK MLDYLKEKKD VGFFQSLAGL
     MQSCSVLDLN AFERQNKAEG LGMVTEEGSG EKVLQDDEFT CDLFRFLQLL CEGHNSDFQN
     YLRTQTGNNT TVNIIISTVD YLLRVQESIS DFYWYYSGKD VIDEQGQRNF SKAIQVAKQV
     FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM KLSQDSSQIE LLKELMDLQK
     DMVVMLLSML EGNVVNGTIG KQMVDMLVES SNNVEMILKF FDMFLKLKDL TSSDTFKEYD
     PDGKGVISKR DFHKAMESHK HYTQSETEFL LSCAETDENE TLDYEEFVKR FHEPAKDIGF
     NVAVLLTNLS EHMPNDTRLQ TFLELAESVL NYFQPFLGRI EIMGSAKRIE RVYFEISESS
     RTQWEKPQVK ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT IFEMQLAAQI SESDLNERSA
     NKEESEKERP EEQGPRMAFF SILTVKSALF ALRYNILTLM RMLSLKSLKK QMKKVKKMTV
     KDMVTAFFSS YWSIFMTLLH FVASVFRGFF RIICSLLLGG SLVEGAKKIK VAELLANMPD
     PTQDEVRGDG EEGERKTLEA ALPSEDLTDL KELTEESDLL SDIFGLDLKR EGGQYKLIPH
     NPNAGLSDLM SNPVPMPEVQ EKFQEQKAKE EEKEEKEETK SEPEKAEGED GEKEEKAKED
     KGKQKLRQLH THRYGEPEVP ESAFWKKIIA YQQKLLNYFA RNFYNMRMLA LFVAFAINFI
     LLFYKVSTSS VVEGKELPTR SSSENAKVTS LDSSSHRIIA VHYVLEESSG YMEPTLRILA
     ILHTVISFFC IIGYYCLKVP LVIFKREKEV ARKLEFDGLY ITEQPSEDDI KGQWDRLVIN
     TQSFPNNYWD KFVKRKVMDK YGEFYGRDRI SELLGMDKAA LDFSDAREKK KPKKDSSLSA
     VLNSIDVKYQ MWKLGVVFTD NSFLYLAWYM TMSVLGHYNN FFFAAHLLDI AMGFKTLRTI
     LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDGDTPDMKC DDMLTCYMFH
     MYVGVRAGGG IGDEIEDPAG DEYEIYRIIF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ
     QEQVKEDMET KCFICGIGND YFDTVPHGFE THTLQEHNLA NYLFFLMYLI NKDETEHTGQ
     ESYVWKMYQE RCWEFFPAGD CFRKQYEDQL N
//
DBGET integrated database retrieval system