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Database: UniProt
Entry: G7P0X3_MACFA
LinkDB: G7P0X3_MACFA
Original site: G7P0X3_MACFA 
ID   G7P0X3_MACFA            Unreviewed;       839 AA.
AC   G7P0X3;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   16-MAR-2016, entry version 10.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=EGM_12998 {ECO:0000313|EMBL:EHH52542.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH52542.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH52542.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CM001278; EHH52542.1; -; Genomic_DNA.
DR   Proteomes; UP000009130; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    403    427       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    447    466       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    545    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    572    596       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    662       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    770    795       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       93    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   839 AA;  96171 MW;  985369C351FEBCB9 CRC64;
     MASVFRSEEM CLSQLFLQVE AAYCCVAELG ELGLVQFKDL NMNVNSFQRK FVNEVRRCES
     LERILRFLED EMQNEIAVQL PEKSPLTPLP REMITLETVL EKLEGELQEA NQNQQALKKS
     FLELTELKYL LKKTQDFFET ETNLADDFFT EDTSGLLELK AVPAHMTGKL GFIAGVINRE
     RMASFERLLW RICRGNVYLK FSEMDAPLED PVTKEEIQKN IFIIFYQGEQ LRQKIKKICD
     GFRATVYPCP EPAVERREML ESVNVRLEDL ITVITQTESH RQRLLQEAAA NWHSWLIKVQ
     KMKAVYHILN MCNIDVTQQC VIAEIWFPVA DATRIKRALE QGMELSGSSM APIMTTVQSK
     TAPPTFNRTN KFTAGFQNIV DAYGVGSYRE INPAPYTIIT FPFLFAVMFG DCGHGTVMLL
     AALWMVLNER RLLSQKTDNE IWNTFFHGRY LILLMGIFSI YTGLIYNDCF SKSLNIFGSS
     WSVQPMFRNG TWNTHVMEEN PYLQLDPAIP GVYFGNPYPF GIDPIWNLAS NKLTFLNSYK
     MKMSVILGIV QMVFGVILSL FNHIYFRRTL NIILQFIPEM IFILCLFGYL VFMIIFKWCC
     FDVHVSQHAP SILIHFINMF LFNYSDSSNA PLYKHQQEVQ SFFVVMALIS VPWMLLIKPF
     ILRASHRKSQ VRAASRIQED ATENIEGDSS SPSSSSGQRT SAHGAQDDHG EEFNFGDIFV
     HQAIHTIEYC LGCISNTASY LRLWALSLAH AQLSEVLWTM VMNNGLQMRG WGGIVGVFII
     FAVFAVLTVA ILLIMEGLSA FLHALRLHWV EFQNKFYVGD GYKFSPFSFK HILDGTAEE
//
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