ID G7P3L1_MACFA Unreviewed; 538 AA.
AC G7P3L1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=IBB domain-containing protein {ECO:0000259|PROSITE:PS51214};
DE Flags: Fragment;
GN ORFNames=EGM_14077 {ECO:0000313|EMBL:EHH53437.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH53437.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH53437.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394}.
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DR EMBL; CM001279; EHH53437.1; -; Genomic_DNA.
DR AlphaFoldDB; G7P3L1; -.
DR eggNOG; KOG0166; Eukaryota.
DR Proteomes; UP000009130; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF10; IMPORTIN SUBUNIT ALPHA-6; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW ProRule:PRU00561}.
FT DOMAIN 1..59
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 169..202
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 211..239
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH53437.1"
FT NON_TER 538
FT /evidence="ECO:0000313|EMBL:EHH53437.1"
SQ SEQUENCE 538 AA; 60445 MW; E4C838BE2B37BB86 CRC64;
DAMASPGKDN YRMKSYKNKA LNPQEMRRRR EEEGIQLRKQ KREEQLFKRR NVSLPRNDES
MLESPIQDPD ISSTVPIPEE EVVTTDMVQM IFSNNADQQL TATQKFRKLL SKEPNPPIDQ
VIQKPGVVQR FVKFLERNEN CTLQFEAAWA LTNIASGTFL HTKVVIETGA VPIFIKLLNS
EHEDVQEQAV WALGNIAGDN AECRDFVLNC EILPPLLELL TNSNRLTTTR NAVWALSNLC
RGKNPPPNFS KVSPCLNVLS RLLFSSDPDV LADVCWALSY LSDGPNDKIQ AVIDSGVCRR
LVELLMHNDY KVVSPALRAV GNIVTGDDIQ TQVILNCSAL PCLLHLLSSP KESIRKEACW
TVSNITAGNR AQIQAVIDAN IFPVLIEILQ KAEFRTRKEA AWAITNATSG GTPEQIRYLV
ALGCIKPLCD LLTVMDSKIV QVALNGLENI LRLGEQESKQ NGIGVNPYCA LIEEAYGLDK
IEFLQSHENQ EIYQKAFDLI EHYFGVEEDD PSIVPQVDEN QQQFIFQQQE APMDGFQL
//
