ID G7PKQ7_MACFA Unreviewed; 3550 AA.
AC G7PKQ7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Xin actin-binding repeat-containing protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGM_04023 {ECO:0000313|EMBL:EHH54916.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH54916.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH54916.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- FUNCTION: Protects actin filaments from depolymerization.
CC {ECO:0000256|ARBA:ARBA00002375}.
CC -!- DOMAIN: Xin repeats bind F-actin. {ECO:0000256|PROSITE-
CC ProRule:PRU00721}.
CC -!- SIMILARITY: Belongs to the Xin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00721}.
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DR EMBL; CM001287; EHH54916.1; -; Genomic_DNA.
DR eggNOG; ENOG502SF50; Eukaryota.
DR Proteomes; UP000009130; Chromosome 12.
DR GO; GO:0030054; C:cell junction; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR InterPro; IPR012510; Actin-binding_Xin_repeat.
DR InterPro; IPR030072; XIRP1/XIRP2.
DR PANTHER; PTHR22591; XIN; 1.
DR PANTHER; PTHR22591:SF1; XIN ACTIN-BINDING REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08043; Xin; 18.
DR PROSITE; PS51389; XIN; 27.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00721}.
FT REPEAT 536..551
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 571..586
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 611..626
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 648..663
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 686..701
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 726..741
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 764..779
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 802..817
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 835..850
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 869..884
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 906..921
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 942..957
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1011..1026
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1049..1064
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1088..1103
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1121..1136
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1159..1174
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1194..1209
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1233..1248
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1269..1284
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1306..1321
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1344..1359
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1381..1396
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1415..1430
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1446..1461
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1484..1499
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1519..1534
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REGION 27..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2273..2325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2340..2443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2804..2832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3036..3183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3232..3257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3519..3550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2286..2321
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2362..2376
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2377..2414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3036..3066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3067..3105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3133..3154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3163..3179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3241..3256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3550 AA; 402125 MW; 761BBA7A7CA6FEBA CRC64;
MFPMQKGSLN LLRQKWESCD YQRSECYPRD SRSTILQPQE SKLLEPEEEV VSAPEPLDPT
SLPCSGELTL SSKPEGKDSV DKSNTTREYG RPEVLKEDSL SSRRRIERFS IALDELRSVF
EAPKSGNKSA EHGGKEVEIE RSLCSPAFKS HPGSQLEDSV KDSDEKGEET SCDKMSPESG
HSHIFEAIAG PNKPESGFAE DSAALGEVVS DLHEVVSLKE RMARYQAAVS RGDCRSFSAN
MMEESEMCTV PGGLAKVKKQ FEDEITSSRN TFAQYQYQHQ NRSEQEAIHS SQVGTSKSSQ
ELARNEQEGS KVQKIDVHGT EMVSHLEKHT KEINQASQFH QYVQETVIDT PEDEEIPKVS
TKLLKEQFEK SAQEKILYSD KEMTTPAKQI KIESECEETL KPSSVVSTSS TSCISTSQRK
ETSTTRYSDH SVTSSTLAQI NATSSGMTEE FPPPPPDVLQ TSVDATAFSQ SPELPSPPRR
LPVPKDVYSK QRNLYELNRL YKHIHPELRK NLEKDYISEV SEIVSSQMNS GSSVSADVQQ
ARYVFENTND SSQKDLNSER EYLEWDEILK GEVQSIRWIF ENQPLDSINN GSPDEGDISR
GVADQEIIAG GDVKYTTWMF ETQPIDTLGA HSSDTVENAE KIPELARGDV CTARWMFETR
PLDSMNKMHQ SQEESAVTIS KDITGGNVKT VRYMFETQHL DQLGQLHSVD EVHLLQLRSE
LKEIKGNVKR SIKCFETQPL YVIRDGSGQM LEIKTVHRED VEKGDVRTAR WMFETQPLDT
INKDITEIKI VRGISMEENV KGGVSKAKWL FETQPLEKIK ESEEVIIEKE TIIGTDVSRK
CWMFETQPLD ILKEVPDADP LQHEEIIGGD VQTTKHLFET LPIEALKDSP DIGKLQKITA
SEEEKGDVRH QKWIFETQPL EDIRKDKKEY TRTVKLEEVD RGDVKNYTHI FESNNLIKFD
ASHKIEVEGV TRGAVELNKS LFETTPLYAI QDPLGKYHQV KTVQQEEIIR GDVRSCRWLF
ETRPIDQFDE SIHKFQIIRG ISAQEIQTGN VKSAKWLFET QPLDSIKYFS DVEETESKTE
QARDIIKGDV KTCKWLFETQ PMESLYEKVS LMTSSEEIHK GDVKTCTWLF ETQPLDAIKD
DSETKVKLQT VKQEEIQGGD VRTTCFLFET ENLDSIQGEE VKEIKPVEMD IQAGDVSSMR
YKFENQSLDS ISSSSEEVLK KIKTLKTEDI QKGNVLNCRW LFENQPIDKI KESQEGDECV
KTVTDIQGGD VRKGCFIFET FSLDEIKEES DYISTKKTIT EEVMQGDVKS YRMLFETQPL
YAIQDREGSY HEVTTVKKEE VIHGDVRGTR WLFETKPLDS INKSETVYVI KAVTQEDIQK
GDVSSVRYRF ETQPLDQISE ESHNIVPTVD HIQGGNVKTS KQFFESENFD KNNYIRTVSV
NEIQKGNVKT STWLFETHTI DELRGEGLEY ENIKTVTQED VQKGDVKQAV WLFENQTFDS
IMEAHKGVTK VTKEEIPPSD VKTTTWLFET TPLHEFNENR IEKIEIIGKS IKKTLEDLYS
QKVIQAPGII IEADEVGDVR MAKYKLMNQA SPEIQKEEII RADLRNIMVN LLSKRDYTKR
EILVSEEEKG NVNLTKTQLL NKSTEFHAEK EEIVKGDVQH AIKNLFSEER SVKKGILIQE
DERGDINMTI YCLLHENDGD TIEREEVIGG DVRRTIHNLL SSTSNNKISE RAKIDASERG
NVQFFTTCIE AGALDYLKQL HTESNETLTA KKQEGEKEII GGDVEGTKLL LKKRQSLVER
TVSETDIIPG DVHNTVKVFM TEPQSTLGKT PKEEIIKGDL ASTLNSLSQA VNQKTVTKTE
EIIKGDMLAT LKSLKESTRR WKESKQPDAI PGDIEKAIEC LEKATNTRTE ILKKELLKDD
LETSLRSLKE AQRSFKEVDK EGVIKKDAHV VMAGSSGEQK TDIHQVAVQR NKNSLLQPKS
GPFEPAAEWQ GGADTLSQTM GKSCHGNLVE ERTEVNLPKA PKGSVKIVID REQNNDALEK
SLRRLSNSHH KSIKNVLESG DKMGVWTDIT GEQHLRDEYM SRQLTSTVSV KNNLKTKESD
REVRELKKDD DFNSVQSADK TIGKQQTYER RNDHQKTEAF HIKSPKKTEN IKILTDTQNS
KPSPTQHPVS MPVGGTYKIS GDFQKQTLLK QETKYSNKNI KQKNINFQPM WQPLPVEQDT
TSVTEVKVSE KNHNTFKTTN KKQETDVHLK SQDFLMKTNT STDLKTAMER SLNPINFNPE
NNVKESECPL PPPSPPPPPP SNASSEIEFP LPPPPPLMMF PEKNGFIPSL STEKIKAEFE
SFPGLPLPPP SVDEKSERES PSMFLPPPPP PTPSQNPAHL LSSSAPEKHS GAFMQQYSQK
EASNSQNSQA KIITGKSGVL PPPTLPKPKL PKHIKDNKNH FSPKVELTNS LSDMECKITT
SKDQKKVMMM TSSEHIETKQ NVISKSLDER KQLFVDSANC LSHTVPGTSA PKKKQIAPLI
KSHSFPESSG QQSPKPYMRK FKTPLMIAEE KYRQQKEELE KQKQESSYYN IVKTESQNQH
ISEVEKEMPL RKTNEEVSVS GIDSEHTVVQ PNAGSQSNAR VLGVCSDNQL STTSPVTVTA
KRLHHVLAAS EDKDKMKKEV LQSARDIMQS KSACEIKQSH QECSTQQTQQ NQYLEQLHLP
QSKPISPNFK VKTIKLPTLD HTLNETDHSY ESHKQQSEVD VQTFAKQQYL ETKKTEASTE
CSHKQSLAER HYQLPKKEKR VTIKLPTESI QKNHEDKLQI VPGKQEEFAG SDRGKLPGSE
EKNKGPSMIS RKEERLITER KQEVLKNKSA PKVVKQKVID AHLDSQTQNF QQTQIQTSES
KAEHKKWPQP YNSLQEEKCL QVKGIQQKQV FSNTKDSKQE ITQNKSFFSA VKESQQDDGK
CAINIVEFLR KREELQQILS RVKQFEAEPN KSGLKTFQTL LNTIPGWLIS EEKREYAVHI
AMENNLEKVK EEITHIKTQA EDMLVSYENI IQTAMMSSKT GKSGNKPTSL DETSSKVSNV
HVSNNKNSEQ KENKIAKEKT GQHQVAAHRE AAVHSHVKTH QEIKLDESNI PPPSLKTRPP
SPTFITIEST VRRTETPTKD ELSQSPKKDS YVEPPPRRPM SQTSEIHRAN TSPSPPRSRS
EQLVRLKDTT AKLSKGAIPC PAVTPVPIVE KRSEIIMSPA TLRRQIKIET RGRDSPPTIT
IPVNIHHTPS GSSRESMEAQ EEIRKVEKRT TYVHNAGLNS TDPIVPDTES YDAVEIIRKV
EVPPRLSEHT QRYEAANRTV QMAENFVNDR ENEINRWFRE FEHGPVSEAK SNRRVYANGE
TNHNIQQESH TFCQEEFGLT SLGNTSFTDF SCKHPRELQE KIPVKQPRIC SETRSLSEHF
SGMDAFESQI VESKMKTSSS HSSEAGKSGC DFKHAPPTYE DVIAGHILDI SDSPKEVRKN
FQKTWQESGR VFKSLGYATS DSSATEMRTA FQEESAFISE TAAPRQGNMY TLSKDSLSNG
VPSGRQAEFS
//