ID G7PL03_MACFA Unreviewed; 198 AA.
AC G7PL03;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=BPTI/Kunitz inhibitor domain-containing protein {ECO:0000259|PROSITE:PS50279};
DE Flags: Fragment;
GN ORFNames=EGM_04137 {ECO:0000313|EMBL:EHH55012.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH55012.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH55012.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; CM001287; EHH55012.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PL03; -.
DR ABCD; G7PL03; 1 sequenced antibody.
DR eggNOG; KOG4295; Eukaryota.
DR Proteomes; UP000009130; Chromosome 12.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd22614; Kunitz_TFPI1_2-like; 1.
DR CDD; cd22615; Kunitz_TFPI1_TFPI2_3-like; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 2.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR008296; TFPI-like.
DR PANTHER; PTHR10083; KUNITZ-TYPE PROTEASE INHIBITOR-RELATED; 1.
DR PANTHER; PTHR10083:SF328; TISSUE FACTOR PATHWAY INHIBITOR; 1.
DR Pfam; PF00014; Kunitz_BPTI; 2.
DR PIRSF; PIRSF001620; TFPI; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 2.
DR SUPFAM; SSF57362; BPTI-like; 2.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 2.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 2.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696}.
FT DOMAIN 19..69
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 111..161
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH55012.1"
FT NON_TER 198
FT /evidence="ECO:0000313|EMBL:EHH55012.1"
SQ SEQUENCE 198 AA; 22838 MW; D1D2B007D5BE6262 CRC64;
DNVNRIIQTA LQQEKPDFCF LEEDPGICRG YITRYFYNNQ SKQCERFKYG GCLGNMNNFE
TLEECKNTCE DGLNGFQVDN YGTQLNAVNN SQTPQSTKVP SFFEFHGPSW CLAPADRGLC
RANENRFYYN SVIGKCRPFK YSGCGGNENN FTSKRECLRA CKKGFIQRIS KGGLIKTKRK
RKKQRVKIAY EEVFVKNM
//
