ID   G7PMC7_MACFA            Unreviewed;       337 AA.
AC   G7PMC7;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 55.
DE   SubName: Full=Pleckstrin {ECO:0000313|Ensembl:ENSMFAP00000040721.2};
GN   Name=PLEK {ECO:0000313|Ensembl:ENSMFAP00000040721.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000040721.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000040721.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000040721.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   STRING; 9541.ENSMFAP00000040721; -.
DR   Ensembl; ENSMFAT00000014990.2; ENSMFAP00000040721.2; ENSMFAG00000054603.1.
DR   Ensembl; ENSMFAT00000089233.1; ENSMFAP00000054488.1; ENSMFAG00000054603.1.
DR   VEuPathDB; HostDB:ENSMFAG00000041132; -.
DR   eggNOG; ENOG502QQIA; Eukaryota.
DR   GeneTree; ENSGT00940000157885; -.
DR   OrthoDB; 51135at2759; -.
DR   Proteomes; UP000233100; Chromosome 13.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04445; DEP_PLEK1; 1.
DR   CDD; cd13301; PH1_Pleckstrin_2; 1.
DR   CDD; cd13302; PH2_Pleckstrin_2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037370; Pleckstrin.
DR   InterPro; IPR037371; PLEK_DEP.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12092; PLECKSTRIN; 1.
DR   PANTHER; PTHR12092:SF1; PLECKSTRIN; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00169; PH; 2.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00233; PH; 2.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT   DOMAIN          1..88
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          123..208
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          231..334
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   337 AA;  38439 MW;  945F4B3035E8C9E4 CRC64;
     MGSVFNTWKP MWVVLLEDGI EFYKKKSDNS PKGMIPLKGS TLTSPCQDFG KRMFVFKITT
     TKQQDHFFQA AFLEERDAWV RDIKKGIKCI EGGQKFARKS TRRSIRLPET IDLGALYLSM
     KDTEKGIKEL NLEKDKKIFN HCFTGNCVID WLVSNQSVRN RQEGLMIASS LLNEGYLQPA
     GDMSKSAVDG TAENPFLDNP DAFYYFPDSG FFCEENSSDD DVILKEEFRG VIIKQGCLLK
     QGHRRKNWKV RKFILREDPA YLHYYDPAGA EDPLGAIHLR GCVVTSVESN SNGRKSEEEN
     LFEIITADEV HYFLQAASPK ERTEWIKAIQ VASRTGK
//