ID G7PR62_MACFA Unreviewed; 695 AA.
AC G7PR62;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=G-protein-signaling modulator 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGM_06516 {ECO:0000313|EMBL:EHH56978.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH56978.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH56978.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SIMILARITY: Belongs to the GPSM family.
CC {ECO:0000256|ARBA:ARBA00006600}.
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DR EMBL; CM001290; EHH56978.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PR62; -.
DR eggNOG; KOG1130; Eukaryota.
DR Proteomes; UP000009130; Chromosome 15.
DR GO; GO:0030695; F:GTPase regulator activity; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45954:SF2; G-PROTEIN-SIGNALING MODULATOR 1; 1.
DR PANTHER; PTHR45954; LD33695P; 1.
DR Pfam; PF02188; GoLoco; 2.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 3.
DR SMART; SM00390; GoLoco; 2.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50877; GOLOCO; 2.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 281..314
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 499..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 76502 MW; CB241986F76E47F2 CRC64;
MPSPAVEGPP LALSLAEKAV CKVVYGAPRP RPLLLPVGLE LWLYVQKMRN LQRKRMEASC
LELALEGERL CKAGDFKAGV AFFEAAVQVG TEDLKTLSAI YSQLGNAYFY LKEHGRALEY
HKHDLLLART IGDRMGEAKA SGNLGNTLKV LGRFDEAAVC CQRHLSIAQE QGDKVGEARA
LYNIGNVYHA KGKQLSWNAA NATQDPGHLP PDVRETLCKA SEFYERNLSL VKELGDRAAQ
GRAYGNLGNT HYLLGNFTEA TTFHKERLAI AKEFGDKAAE RRAYSNLGNA HVFLGRFDVA
AEYYKKTLQL SRQLRDQAVE AQACYSLGNT YTLLQDYERA AEYHLRHLLI AQELADRVGE
GRACWSLGNA YVSMGRPAQA LTFAKKHLQI SQEIGDRHGE LTARMNVAQL QLVLGRLTSP
AASEKPDLAG YEAQGLLAEG QEVVTYCPAG CSGASTPPHL PLEHLVQGGL LSSDPGARPK
RTQRLSAETW DLLRLPLERE QNGDSHHAGD WRGPSRDSLP IPVRSRKYQE GPDAERRPRE
GSHSPLDSAD VRVHVPRTSI PRAPSSDEEC FFDLLTKFQS SRMDDQRCPL DDGQAGAAEA
TAAPTLEDRI AQPSMTASPQ TEEFFDLIAS SQSRRLDDQR ASVGSLPGLR ITHSNAGHLR
GHGEPQEPGD DFFNMLIKYQ VMFEGLLGDS ASVTR
//
