ID G7Q1M4_MACFA Unreviewed; 470 AA.
AC G7Q1M4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Mixed lineage kinase domain-like protein {ECO:0000313|EMBL:EHH60562.1};
GN ORFNames=EGM_11948 {ECO:0000313|EMBL:EHH60562.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH60562.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH60562.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; CM001295; EHH60562.1; -; Genomic_DNA.
DR AlphaFoldDB; G7Q1M4; -.
DR SMR; G7Q1M4; -.
DR eggNOG; KOG0192; Eukaryota.
DR Proteomes; UP000009130; Chromosome 20.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0070266; P:necroptotic process; ISS:UniProtKB.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd21037; MLKL_NTD; 1.
DR Gene3D; 1.20.930.20; Adaptor protein Cbl, N-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR036537; Adaptor_Cbl_N_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR44329:SF313; MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR44329; SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:EHH60562.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000313|EMBL:EHH60562.1}.
FT DOMAIN 193..469
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT COILED 55..82
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 148..175
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 470 AA; 54735 MW; C2707B8A875D8B4B CRC64;
MENLKHIITL GQVIHKQCEE MKYCKKQCRR LGHRVLGLVE SLEMLQDQGK RSVPSEKLTT
VMNRFKAALE KANEEIEKFS NRSNICRFLT ASQDKILFED VNKNLNDVWK ELSLLLQIEQ
RMPVSRISQG ASWAQEDQQD ADEDRRAFQM LRRDNEEIEA SLRRLEINMK EIKETLRQHL
LPKCMQIPQE QIKEIKKEQL SGSPWILLRE NKVSTLYKGE YHRAPVTIKV FNNPQAGSIA
IVRQTFNDEI KIMKKFESPN ILRIFGICID ETVTPPQFSI VMEYCELGTL RELLDREEDL
TLSKRIVLVL GAARGLYWLH HSEEPELHGK IRSSNFLVTQ GYQVKLAGFE LRKTQTSISL
KTKREKTDRV KSTAYISPQK LENIYHRYDV KSEIYSFGIV LWEIVTGRIP FEGCNSEKIY
ELVAVKRQQE PLGEDCPSEL REIIDECRAH DPSVRPSVDE ILKKLSTFTK
//
