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Database: UniProt
Entry: G7RUX3_KLEPN
LinkDB: G7RUX3_KLEPN
Original site: G7RUX3_KLEPN 
ID   G7RUX3_KLEPN            Unreviewed;       336 AA.
AC   G7RUX3;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   24-JAN-2024, entry version 94.
DE   SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:ALI93472.1};
DE   SubName: Full=Phosphonate dehydrogenase {ECO:0000313|EMBL:AET17078.1, ECO:0000313|EMBL:AEV55093.1};
DE            EC=1.20.1.1 {ECO:0000313|EMBL:NGN76078.1, ECO:0000313|EMBL:SLT06270.1};
DE   SubName: Full=Phosphonate dehydrogenase PtxD {ECO:0000313|EMBL:NGN76078.1};
DE   SubName: Full=VanH-D_1_AB242319 {ECO:0000313|EMBL:VCY43321.1};
GN   Name=ptxD {ECO:0000313|EMBL:AET17078.1};
GN   ORFNames=B5L96_00010 {ECO:0000313|EMBL:OVF79777.1}, BANRA_05232
GN   {ECO:0000313|EMBL:VCY43321.1}, BL124_00009190
GN   {ECO:0000313|EMBL:ROG99185.1}, EAO17_27755
GN   {ECO:0000313|EMBL:RRE94536.1}, G4V31_28875
GN   {ECO:0000313|EMBL:NGN76078.1}, HC139_27920
GN   {ECO:0000313|EMBL:NJK06860.1}, NCTC13443_07152
GN   {ECO:0000313|EMBL:STV75314.1}, PUUH_pUUH2392p0004
GN   {ECO:0000313|EMBL:AET17078.1}, SAMEA3499874_05292
GN   {ECO:0000313|EMBL:SXG19382.1}, SAMEA3538658_05308
GN   {ECO:0000313|EMBL:SYK86287.1}, SAMEA3720909_05457
GN   {ECO:0000313|EMBL:SWF77838.1}, SAMEA3721128_05140
GN   {ECO:0000313|EMBL:SWG54282.1}, SAMEA3727687_05262
GN   {ECO:0000313|EMBL:SWR95787.1}, SAMEA4370542_05602
GN   {ECO:0000313|EMBL:SLT06270.1};
OS   Klebsiella pneumoniae.
OG   Plasmid PU25001 {ECO:0000313|EMBL:ALI93472.1},
OG   Plasmid pBK32179 {ECO:0000313|EMBL:AGC23594.1},
OG   Plasmid pKN-LS6 {ECO:0000313|EMBL:AGO62381.1},
OG   Plasmid pKP007 {ECO:0000313|EMBL:AHG55724.1},
OG   Plasmid pKP02022 {ECO:0000313|EMBL:AHG55939.1},
OG   Plasmid pKP09085 {ECO:0000313|EMBL:AHG55520.1},
OG   Plasmid pKPN-IT {ECO:0000313|EMBL:AEV55093.1}, and
OG   Plasmid pUUH239.2 {ECO:0000313|EMBL:AET17078.1}.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:AET17078.1};
RN   [1] {ECO:0000313|EMBL:AEV55093.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ST258 {ECO:0000313|EMBL:AEV55093.1};
RC   PLASMID=pKPN-IT {ECO:0000313|EMBL:AEV55093.1};
RX   PubMed=22252815; DOI=10.1128/AAC.05308-11;
RA   Garcia-Fernandez A., Villa L., Carta C., Venditti C., Giordano A.,
RA   Venditti M., Mancini C., Carattoli A.;
RT   "Klebsiella pneumoniae ST258 Producing KPC-3 Identified in Italy Carries
RT   Novel Plasmids and OmpK36/OmpK35 Porin Variants.";
RL   Antimicrob. Agents Chemother. 56:2143-2145(2012).
RN   [2] {ECO:0000313|EMBL:AET17078.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=U-0608239 {ECO:0000313|EMBL:AET17078.1};
RC   PLASMID=pUUH239.2 {ECO:0000313|EMBL:AET17078.1};
RX   PubMed=21990049; DOI=10.1093/jac/dkr405;
RA   Sandegren L., Linkevicius M., Lytsy B., Melhus A., Andersson D.I.;
RT   "Transfer of an Escherichia coli ST131 multiresistance cassette has created
RT   a Klebsiella pneumoniae-specific plasmid associated with a major nosocomial
RT   outbreak.";
RL   J. Antimicrob. Chemother. 67:74-83(2012).
RN   [3] {ECO:0000313|EMBL:AGC23594.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BK32179 {ECO:0000313|EMBL:AGC23594.1};
RC   PLASMID=pBK32179 {ECO:0000313|EMBL:AGC23594.1};
RX   PubMed=23295924; DOI=10.1128/AAC.02332-12;
RA   Chen L., Chavda K.D., Melano R.G., Jacobs M.R., Levi M.H., Bonomo R.A.,
RA   Kreiswirth B.N.;
RT   "Complete sequence of a bla(KPC-2)-harboring IncFII(K1) plasmid from a
RT   Klebsiella pneumoniae sequence type 258 strain.";
RL   Antimicrob. Agents Chemother. 57:1542-1545(2013).
RN   [4] {ECO:0000313|EMBL:AGO62381.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LS6 {ECO:0000313|EMBL:AGO62381.1};
RC   PLASMID=pKN-LS6 {ECO:0000313|EMBL:AGO62381.1};
RX   PubMed=23800906; DOI=10.1093/jac/dkt235;
RA   Villa L., Capone A., Fortini D., Dolejska M., Rodriguez I., Taglietti F.,
RA   De Paolis P., Petrosillo N., Carattoli A.;
RT   "Reversion to susceptibility of a carbapenem-resistant clinical isolate of
RT   Klebsiella pneumoniae producing KPC-3.";
RL   J. Antimicrob. Chemother. 68:2482-2486(2013).
RN   [5] {ECO:0000313|EMBL:AHG55520.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ST15 {ECO:0000313|EMBL:AHG55939.1}, ST23
RC   {ECO:0000313|EMBL:AHG55724.1}, and ST48 {ECO:0000313|EMBL:AHG55520.1};
RC   PLASMID=pKP007 {ECO:0000313|EMBL:AHG55724.1}, pKP02022
RC   {ECO:0000313|EMBL:AHG55939.1}, and pKP09085
RC   {ECO:0000313|EMBL:AHG55520.1};
RX   PubMed=24257316; DOI=10.1093/jac/dkt464;
RA   Shin J., Soo Ko K.;
RT   "Single origin of three plasmids bearing blaCTX-M-15 from different
RT   Klebsiella pneumoniae clones.";
RL   J. Antimicrob. Chemother. 69:969-972(2014).
RN   [6] {ECO:0000313|EMBL:ALI93472.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=U25 {ECO:0000313|EMBL:ALI93472.1};
RC   PLASMID=PU25001 {ECO:0000313|EMBL:ALI93472.1};
RX   PubMed=26872343; DOI=10.1590/0074-02760150423;
RA   Rafiq Z., Sam N., Vaidyanathan R.;
RT   "Whole genome sequence of Klebsiella pneumoniae U25, a hypermucoviscous,
RT   multidrug resistant, biofilm producing isolate from India.";
RL   Mem. Inst. Oswaldo Cruz 111:144-146(2016).
RN   [7] {ECO:0000313|EMBL:OVF79777.1, ECO:0000313|Proteomes:UP000196447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=39383 {ECO:0000313|EMBL:OVF79777.1,
RC   ECO:0000313|Proteomes:UP000196447};
RA   Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K.,
RA   Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B.,
RA   Adams M.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:RRE94536.1, ECO:0000313|Proteomes:UP000275975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLPN_104 {ECO:0000313|EMBL:RRE94536.1,
RC   ECO:0000313|Proteomes:UP000275975};
RX   PubMed=30373801;
RA   Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA   Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT   "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial
RT   Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella
RT   pneumoniae Clinical Isolates.";
RL   Antimicrob. Agents Chemother. 0:0-0(2018).
RN   [9] {ECO:0000313|EMBL:STV75314.1, ECO:0000313|Proteomes:UP000255518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13443 {ECO:0000313|EMBL:STV75314.1,
RC   ECO:0000313|Proteomes:UP000255518};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|Proteomes:UP000257587, ECO:0000313|Proteomes:UP000258808}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EuSCAPE_AT002 {ECO:0000313|EMBL:SXG19382.1,
RC   ECO:0000313|Proteomes:UP000257587}, EuSCAPE_BE100
RC   {ECO:0000313|EMBL:SWR95787.1, ECO:0000313|Proteomes:UP000259946},
RC   EuSCAPE_HR098 {ECO:0000313|EMBL:SWG54282.1,
RC   ECO:0000313|Proteomes:UP000259884}, EuSCAPE_IT290
RC   {ECO:0000313|EMBL:SYK86287.1, ECO:0000313|Proteomes:UP000258808},
RC   EuSCAPE_UK014 {ECO:0000313|EMBL:SWF77838.1,
RC   ECO:0000313|Proteomes:UP000259364}, and VRES1272
RC   {ECO:0000313|EMBL:SLT06270.1, ECO:0000313|Proteomes:UP000191996};
RG   Pathogen Informatics;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:ROG99185.1, ECO:0000313|Proteomes:UP000283322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRK0165 {ECO:0000313|EMBL:ROG99185.1,
RC   ECO:0000313|Proteomes:UP000283322};
RA   Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA   Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:VCY43321.1, ECO:0000313|Proteomes:UP000278966}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kpneu025 {ECO:0000313|EMBL:VCY43321.1};
RA   Noll B N.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:NGN76078.1, ECO:0000313|Proteomes:UP000479475}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2429 {ECO:0000313|EMBL:NGN76078.1,
RC   ECO:0000313|Proteomes:UP000479475};
RA   Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V.,
RA   Sopova J.V., Sidorenko S.V.;
RT   "Klebsiella pneumoniae genome sequencing and assembly.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:NJK06860.1, ECO:0000313|Proteomes:UP000551791}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMB8492 {ECO:0000313|EMBL:NJK06860.1,
RC   ECO:0000313|Proteomes:UP000551791};
RA   Miller-Ensminger T., Wolfe A.J., Putonti C.;
RT   "Draft genome sequences of bacterial isolates from the female urobiome.";
RL   Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR   EMBL; CP002474; AET17078.1; -; Genomic_DNA.
DR   EMBL; JN233704; AEV55093.1; -; Genomic_DNA.
DR   EMBL; JX430448; AGC23594.1; -; Genomic_DNA.
DR   EMBL; JX442974; AGO62381.1; -; Genomic_DNA.
DR   EMBL; KF719970; AHG55520.1; -; Genomic_DNA.
DR   EMBL; KF719971; AHG55724.1; -; Genomic_DNA.
DR   EMBL; KF719972; AHG55939.1; -; Genomic_DNA.
DR   EMBL; KT203286; ALI93472.1; -; Genomic_DNA.
DR   EMBL; JAAKYD010000061; NGN76078.1; -; Genomic_DNA.
DR   EMBL; JAAUVU010000076; NJK06860.1; -; Genomic_DNA.
DR   EMBL; NDBK01000001; OVF79777.1; -; Genomic_DNA.
DR   EMBL; MPYG04000071; ROG99185.1; -; Genomic_DNA.
DR   EMBL; RDAM01000002; RRE94536.1; -; Genomic_DNA.
DR   EMBL; FWJM01000042; SLT06270.1; -; Genomic_DNA.
DR   EMBL; UGKT01000003; STV75314.1; -; Genomic_DNA.
DR   EMBL; UJHH01000058; SWF77838.1; -; Genomic_DNA.
DR   EMBL; UJHY01000035; SWG54282.1; -; Genomic_DNA.
DR   EMBL; UJQI01000043; SWR95787.1; -; Genomic_DNA.
DR   EMBL; UKAW01000039; SXG19382.1; -; Genomic_DNA.
DR   EMBL; UKXO01000054; SYK86287.1; -; Genomic_DNA.
DR   EMBL; UWWS01000002; VCY43321.1; -; Genomic_DNA.
DR   RefSeq; WP_004152693.1; NZ_WWPX01000055.1.
DR   RefSeq; YP_005351251.1; NC_016966.1.
DR   RefSeq; YP_007366485.1; NC_020132.1.
DR   RefSeq; YP_008146272.1; NC_021654.1.
DR   RefSeq; YP_008998919.1; NC_023332.1.
DR   RefSeq; YP_008999123.1; NC_023333.1.
DR   RefSeq; YP_008999338.1; NC_023334.1.
DR   GeneID; 78234983; -.
DR   KEGG; kpne:KU54_00065; -.
DR   KEGG; kpnu:LI86_26935; -.
DR   KEGG; kpx:PMK1_a00057; -.
DR   PATRIC; fig|573.1347.peg.5490; -.
DR   Proteomes; UP000191996; Unassembled WGS sequence.
DR   Proteomes; UP000196447; Unassembled WGS sequence.
DR   Proteomes; UP000255518; Unassembled WGS sequence.
DR   Proteomes; UP000257587; Unassembled WGS sequence.
DR   Proteomes; UP000258808; Unassembled WGS sequence.
DR   Proteomes; UP000259364; Unassembled WGS sequence.
DR   Proteomes; UP000259884; Unassembled WGS sequence.
DR   Proteomes; UP000259946; Unassembled WGS sequence.
DR   Proteomes; UP000275975; Unassembled WGS sequence.
DR   Proteomes; UP000278966; Unassembled WGS sequence.
DR   Proteomes; UP000283322; Unassembled WGS sequence.
DR   Proteomes; UP000479475; Unassembled WGS sequence.
DR   Proteomes; UP000551791; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0050609; F:phosphonate dehydrogenase activity; IEA:UniProtKB-EC.
DR   CDD; cd12157; PTDH; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR10996:SF257; ZGC:136493; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719,
KW   ECO:0000313|EMBL:NGN76078.1}; Plasmid {ECO:0000313|EMBL:AET17078.1}.
FT   DOMAIN          6..326
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          110..294
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   336 AA;  36397 MW;  83F8C6C2EB8DD408 CRC64;
     MLPKLVITHR VHDEILQLLA PHCELVTNQT DSTLTREEIL RRCRDAQAMM AFMPDRVDAD
     FLQACPELRV VGCALKGFDN FDVDACTARG VWLTFVPDLL TVPTAELAIG LAVGLGRHLR
     AADAFVRSGE FQGWQPQFYG TGLDNATVGI LGMGAIGLAM AERLQGWGAT LQYHEAKALD
     TQTEQRLGLR QVACSELFAS SDFILLALPL NADTQHLVNA ELLALVRPGA LLVNPCRGSV
     VDEAAVLAAL ERGQLGGYAA DVFEMEDWAR ADRPRLIDPA LLAHPNTLFT PHIGSAVRAV
     RLEIERCAAQ NIIQVLAGAR PINAANRLPK AEPAAC
//
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