ID G7RV42_KLEPN Unreviewed; 423 AA.
AC G7RV42;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE SubName: Full=DNA polymerase V subunit {ECO:0000313|EMBL:AET17147.1, ECO:0000313|EMBL:STX11701.1};
DE SubName: Full=Y-family DNA polymerase {ECO:0000313|EMBL:NGN75968.1};
GN Name=umuC {ECO:0000313|EMBL:AET17147.1};
GN Synonyms=umuC_6 {ECO:0000313|EMBL:STX11701.1};
GN ORFNames=G4V31_28230 {ECO:0000313|EMBL:NGN75968.1}, NCTC11679_06159
GN {ECO:0000313|EMBL:STX11701.1}, PUUH_pUUH2392p0075
GN {ECO:0000313|EMBL:AET17147.1};
OS Klebsiella pneumoniae.
OG Plasmid pKP007 {ECO:0000313|EMBL:AHG55793.1},
OG Plasmid pKP02022 {ECO:0000313|EMBL:AHG56008.1}, and
OG Plasmid pUUH239.2 {ECO:0000313|EMBL:AET17147.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573 {ECO:0000313|EMBL:AET17147.1};
RN [1] {ECO:0000313|EMBL:AET17147.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=U-0608239 {ECO:0000313|EMBL:AET17147.1};
RC PLASMID=pUUH239.2 {ECO:0000313|EMBL:AET17147.1};
RX PubMed=21990049; DOI=10.1093/jac/dkr405;
RA Sandegren L., Linkevicius M., Lytsy B., Melhus A., Andersson D.I.;
RT "Transfer of an Escherichia coli ST131 multiresistance cassette has created
RT a Klebsiella pneumoniae-specific plasmid associated with a major nosocomial
RT outbreak.";
RL J. Antimicrob. Chemother. 67:74-83(2012).
RN [2] {ECO:0000313|EMBL:AHG55793.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ST15 {ECO:0000313|EMBL:AHG56008.1}, and ST23
RC {ECO:0000313|EMBL:AHG55793.1};
RC PLASMID=pKP007 {ECO:0000313|EMBL:AHG55793.1}, and pKP02022
RC {ECO:0000313|EMBL:AHG56008.1};
RX PubMed=24257316; DOI=10.1093/jac/dkt464;
RA Shin J., Soo Ko K.;
RT "Single origin of three plasmids bearing blaCTX-M-15 from different
RT Klebsiella pneumoniae clones.";
RL J. Antimicrob. Chemother. 69:969-972(2014).
RN [3] {ECO:0000313|EMBL:STX11701.1, ECO:0000313|Proteomes:UP000255239}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STX11701.1,
RC ECO:0000313|Proteomes:UP000255239};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:NGN75968.1, ECO:0000313|Proteomes:UP000479475}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2429 {ECO:0000313|EMBL:NGN75968.1,
RC ECO:0000313|Proteomes:UP000479475};
RA Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V.,
RA Sopova J.V., Sidorenko S.V.;
RT "Klebsiella pneumoniae genome sequencing and assembly.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; CP002474; AET17147.1; -; Genomic_DNA.
DR EMBL; KF719971; AHG55793.1; -; Genomic_DNA.
DR EMBL; KF719972; AHG56008.1; -; Genomic_DNA.
DR EMBL; JAAKYD010000047; NGN75968.1; -; Genomic_DNA.
DR EMBL; UGMG01000003; STX11701.1; -; Genomic_DNA.
DR RefSeq; WP_014386156.1; NZ_WXZY01000067.1.
DR RefSeq; YP_005351320.1; NC_016966.1.
DR RefSeq; YP_008999192.1; NC_023333.1.
DR RefSeq; YP_008999407.1; NC_023334.1.
DR KEGG; kpnk:BN49_pII0006; -.
DR PATRIC; fig|573.1362.peg.106; -.
DR Proteomes; UP000255239; Unassembled WGS sequence.
DR Proteomes; UP000479475; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR CDD; cd01700; PolY_Pol_V_umuC; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR025188; DUF4113.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11076:SF34; PROTEIN UMUC; 1.
DR Pfam; PF13438; DUF4113; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00023199};
KW Plasmid {ECO:0000313|EMBL:AET17147.1};
KW SOS mutagenesis {ECO:0000256|ARBA:ARBA00023199};
KW SOS response {ECO:0000256|ARBA:ARBA00023236}.
FT DOMAIN 2..189
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 423 AA; 47565 MW; 7380FD238B051858 CRC64;
MFALADVNSF YASCEKVFRP DLRGKPVVVL SNNDGCVIAR SAEAKLLGIK MGTPWFQLKE
AQFPEKLYVF SSNYELYASL SNRVVALLEE LSPRVEQYSI DECFLDARGI GHCMDLEDFG
RQLRGHVLSG TGLTIGVGFG ATKTLAKSAQ WASKEWPQFR GVLALSPENP RRTAKLLSLQ
PVEEIWGVGN RIAKKLHVMG ITTALQLSLT NPTFIRKNFN VVLERTVREL NGESCISLEE
APPPKQQIVC SRSFGQRITT YEEMRQAVCQ YAERAAEKLR GERQYCRHIS TFIKTSPFAV
NEPYYGNVAT EKLNTPTRDT RDIIAAAVRS LDRIWLDGHR YAKAGIMLND FSPNGVAQLN
LFDDVQPRPH SDALMKVLDG INHSGLGKVW FAGRGIAPDW QMKREMLSPA YTTRWKELPV
ARF
//
