ID G7V5S0_THELD Unreviewed; 1241 AA.
AC G7V5S0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Molybdopterin oxidoreductase {ECO:0000313|EMBL:AER66980.1};
GN OrderedLocusNames=Tlie_1249 {ECO:0000313|EMBL:AER66980.1};
OS Thermovirga lienii (strain ATCC BAA-1197 / DSM 17291 / Cas60314).
OC Bacteria; Synergistota; Synergistia; Synergistales; Thermovirgaceae;
OC Thermovirga.
OX NCBI_TaxID=580340 {ECO:0000313|EMBL:AER66980.1, ECO:0000313|Proteomes:UP000005868};
RN [1] {ECO:0000313|Proteomes:UP000005868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1197 / DSM 17291 / Cas60314
RC {ECO:0000313|Proteomes:UP000005868};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Saunders E.,
RA Kyrpides N., Mavromatis K., Ivanova N., Last F.I., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Spring S., Schroeder M., Brambilla E.-M.,
RA Klenk H.-P., Eisen J.A.;
RT "The complete genome of chromosome of Thermovirga lienii DSM 17291.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AER66980.1, ECO:0000313|Proteomes:UP000005868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1197 / DSM 17291 / Cas60314
RC {ECO:0000313|Proteomes:UP000005868};
RX PubMed=22768366; DOI=10.4056/sigs.2726028;
RA Goker M., Saunders E., Lapidus A., Nolan M., Lucas S., Hammon N.,
RA Deshpande S., Cheng J.F., Han C., Tapia R., Goodwin L.A., Pitluck S.,
RA Liolios K., Mavromatis K., Pagani I., Ivanova N., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Chang Y.J., Jeffries C.D.,
RA Brambilla E.M., Rohde M., Spring S., Detter J.C., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Genome sequence of the moderately thermophilic, amino-acid-degrading and
RT sulfur-reducing bacterium Thermovirga lienii type strain (Cas60314(T)).";
RL Stand. Genomic Sci. 6:230-239(2012).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP003096; AER66980.1; -; Genomic_DNA.
DR RefSeq; WP_014163396.1; NC_016148.1.
DR AlphaFoldDB; G7V5S0; -.
DR STRING; 580340.Tlie_1249; -.
DR KEGG; tli:Tlie_1249; -.
DR eggNOG; COG0493; Bacteria.
DR eggNOG; COG3383; Bacteria.
DR HOGENOM; CLU_000422_0_0_0; -.
DR OrthoDB; 9803192at2; -.
DR Proteomes; UP000005868; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 3.10.20.740; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR028261; DPD_II.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF14691; Fer4_20; 1.
DR Pfam; PF12838; Fer4_7; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00419; ADXRDTASE.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR SUPFAM; SSF51971; Nucleotide-binding domain; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005868}.
FT DOMAIN 3..81
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
FT DOMAIN 605..637
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 649..678
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 687..747
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 1241 AA; 136727 MW; 825BCBD5972FAD79 CRC64;
MERTVSVILN GKTVKGYPGQ KILDLCAENG IEIPTLCYDK HLSLYGGCSI CLVEVKGARS
LVRACATPIQ EGMEIETHTE RVKGARKLAL ELLLSDHVGD CRPPCQLACP ARADVKSYVN
LAAEGKFRSA LDVLHQGITL PASIGRVCPA PCQEKCRRHF VDEEPVSIRE IKRYIGDWGL
SQGDLGEIPQ IKENGKSVAI VGGGPAGLSA AYYLRLKGYK VTIFEKESKL GGMMRYGIPD
YRLPQEILEK ECQWLLAHGI ETRMNTALGK DVTLEELKKQ YDAVLLAMGC WKSTPMRVPG
EDLPGVIGGI EFLYKVNNKQ ETGIGKKVAI IGGGNTAMDA ARCSLREGAE KVYVVYRRTR
EEMPAEDIEI EEAMEEGVEF IFLAAPTAIE GNSRVESIVC EKMALGAPDA SGRRRPIPTG
ETFTLEVDTV IAAIGQRIDL SSLPQDIHDG KWLKVDEHFA TPYEGVFVCG DQKTGPGIAV
EAIGSGHWAA ESIHHYLTEG IPHRPFECDV VRDDLGPEDF LDVEKQPMEK PLILEPQERL
SKPYEEFNKG LTEEQVTIDG SRCMKCGCPD IHECKLREYS IEYEASPDAF PKELYSRPDR
PEEANTYYIR NMDKCIQCGV CVRTCEEIAN CHAIDFQKRG IKTFVGPGVD RTIEHSDCIF
CGLCVQNCPT GALVERTSFG ISRPSKTKLS KTICTYCSVG CELVAHTDLL TGRIDNVTAD
LDNQMSINKG KICAKGRFDW QFVNRDDRIK TPLIKVNGTF QEASWVEALE FVSKKLMAIK
DQYGSDSIGF CASNHCTNEE NYLLQRFARE VVGTNNVDTV DSTYYMPVIN GLTSTLGTVA
MTNDFDSLKN ANVILLLEAN LAETHPVAEM WIKELKKASS TKLLISNSTP TKLDRYADIT
LQQNKGTAVA LLNGLMHIIV EEGLYNSDYV MNNTENFGEL KKLLSEYSPS KVAAITGIPE
KALREAARTF ASGPNSAIIF GDCLLQLENA EETVKSIANL ALLCGMLGRP GTGIYPVVGA
SNTVGAFDMG CTPRLLPGYL PSNDETARSK VEAIWNCSLP TREGHGILDM IDKASKGELK
AMYIMGSDIA KKLSCKDALS NLDLLVVQDI FLNETAQLAD VVLPAACWGE KDGTKTNACR
VVQKTSKAAE APQDARPDWW ILTQLAEACG RSWSFENPES IMNEISNVAD IYGGITYDRL
NTKGLAWPCW NLKHEGTPIL FTEGFHNRKA RFAPCEWKSA N
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