ID G7WLW6_METH6 Unreviewed; 893 AA.
AC G7WLW6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=Mhar_0322 {ECO:0000313|EMBL:AET63709.1};
OS Methanothrix harundinacea (strain 6Ac) (Methanosaeta harundinacea).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanotrichales; Methanotrichaceae; Methanothrix.
OX NCBI_TaxID=1110509 {ECO:0000313|EMBL:AET63709.1, ECO:0000313|Proteomes:UP000005877};
RN [1] {ECO:0000313|EMBL:AET63709.1, ECO:0000313|Proteomes:UP000005877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6Ac {ECO:0000313|EMBL:AET63709.1,
RC ECO:0000313|Proteomes:UP000005877};
RX PubMed=22590603; DOI=10.1371/journal.pone.0036756;
RA Zhu J., Zheng H., Ai G., Zhang G., Liu D., Liu X., Dong X.;
RT "The genome characteristics and predicted function of methyl-group
RT oxidation pathway in the obligate aceticlastic methanogens, Methanosaeta
RT spp.";
RL PLoS ONE 7:E36756-E36756(2012).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP003117; AET63709.1; -; Genomic_DNA.
DR AlphaFoldDB; G7WLW6; -.
DR STRING; 1110509.Mhar_0322; -.
DR KEGG; mhi:Mhar_0322; -.
DR PATRIC; fig|1110509.7.peg.363; -.
DR HOGENOM; CLU_002472_3_1_2; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 146065at2157; -.
DR Proteomes; UP000005877; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000005877}.
FT DOMAIN 691..707
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 831..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 617..624
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 893 AA; 97863 MW; 45900389256DE651 CRC64;
MAKISPLMDQ YFGMKEECGD ALLLFRMGDF YETFGPDAEI AARVLNITLT SRQKDKEGNR
IPLAGIPHHA LDAYLPKLVA AGYKVAICEQ VEDPRKAKGL VKREIIRVIT PGTILEPSML
EEGSNNYLAS IVEDDGKIGL SLLDVSTGEF LATELLATGG KLSTELAKFR PAECLIPRSA
ESLVGDGEGM MVQRLDDADF ALVGARARLA DHFGGERVER WGLPAHPAAA RACGAVLTYL
QSARLPALDH IAEVRLYSPE DFMVLDETTL RNLEIFRNIR DRSKRGTLVD FLDETTTPGG
SRTLRKWLQM PLLSHEDIER RLDAVEELVG DPLLRADLRE ALRGGGDLER VVGRTSCGTA
SPKDLRALKG SIEGLPRIVA ILTAARSEEL VRLRERLEIG PLGEVADLIG RAIADDPPSA
IREGGIIRDG YDPELDGLRS LLREGRGWIA RMERQERDRT GIKSLRVGYN NVFGYYIEVT
KANLSAVPPE YIRKQTLAGG ERFITPELKE MESRVLSAQE RSASLEEEIF ISVRREAAAK
SREILERGEA LGELDVLVTL AAVAADGEFV RPQLNDRGEI SMRASRHPIL ERAMRGGFVA
NDVDLDGRSN RVIILTGPNM AGKSTYMRQI ALAIILAQIG SFVPAAFASI SPVDRIFTRV
GAYDDLSAGQ STFMIEMTEL AKILSSATSK SLILLDEIGR GTSTFDGLAI AWSVTEHIHN
RVRGKAVFAT HYHQLTQLAG VLPGVKNYNM AVKEEGETVL FLRTVVPGAT DRSYGIHVAK
LAGVPEAVVA RAKEILREIE GEAVIEPLAG GPRRRRGGPK YTQLIFFQEP KPRAEGEDGP
GFMGEGHAPT DGGGVEILKE MRDLDVNGLT PLEAINKLSE YQRRLLEDSD GEN
//