GenomeNet

Database: UniProt
Entry: G7WN24_METH6
LinkDB: G7WN24_METH6
Original site: G7WN24_METH6 
ID   G7WN24_METH6            Unreviewed;       559 AA.
AC   G7WN24;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   25-OCT-2017, entry version 32.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   OrderedLocusNames=Mhar_0498 {ECO:0000313|EMBL:AET63880.1};
OS   Methanosaeta harundinacea (strain 6Ac).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosaetaceae; Methanosaeta.
OX   NCBI_TaxID=1110509 {ECO:0000313|EMBL:AET63880.1, ECO:0000313|Proteomes:UP000005877};
RN   [1] {ECO:0000313|EMBL:AET63880.1, ECO:0000313|Proteomes:UP000005877}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6Ac {ECO:0000313|EMBL:AET63880.1,
RC   ECO:0000313|Proteomes:UP000005877};
RX   PubMed=22590603; DOI=10.1371/journal.pone.0036756;
RA   Zhu J., Zheng H., Ai G., Zhang G., Liu D., Liu X., Dong X.;
RT   "The genome characteristics and predicted function of methyl-group
RT   oxidation pathway in the obligate aceticlastic methanogens,
RT   Methanosaeta spp.";
RL   PLoS ONE 7:E36756-E36756(2012).
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP003117; AET63880.1; -; Genomic_DNA.
DR   RefSeq; WP_014586065.1; NC_017527.1.
DR   STRING; 1110509.Mhar_0498; -.
DR   EnsemblBacteria; AET63880; AET63880; Mhar_0498.
DR   GeneID; 12509667; -.
DR   KEGG; mhi:Mhar_0498; -.
DR   PATRIC; fig|1110509.7.peg.550; -.
DR   eggNOG; arCOG04857; Archaea.
DR   eggNOG; COG4058; LUCA.
DR   KO; K00399; -.
DR   OMA; GRVCDGG; -.
DR   OrthoDB; POG093Z00ZI; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000005877; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005877};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000005877};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262}.
FT   DOMAIN        7    276       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      324    450       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       155    155       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     265    265       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     279    279       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   559 AA;  61358 MW;  BB377FBE9E2E4EFC CRC64;
     MGKIHTKKLF VKALNKKFGR DFDLSGTKTV YERLGPEQNA RKREFMEASK KLEGKRGISM
     YNPYLHAGGV PLGQRQLVPY KLSTTEYIVE GDDLHFVNNP AMQQMWDDIR RTIVVGLDMA
     HEVLEKRLGK EVTPETINNY LEILNHAMPG AAVVQEHMVE THPALVDDCN VRMFTGDDDL
     ADEIDDQYLI DVNKLFPAEQ AEEIKAAMGK TSWQAIHIPT IVSRTCDGGT TSRWSAMQLS
     MTFIDAYNMC AGEAAVADLA FAAKHAAVIQ MADMLPARRA RGPNEPGGLS FGFLADMVQT
     SRVKPFDPPQ VSLNVVAAGA MLYDQIWLGS YMSGGVGFTQ YATAAYTNDV LDDFSYYACD
     YGVDKFGDWG KAPATLETSK DIATETTLYA MEQYESFPTL LEDHFGGSQR SAVMAAASAI
     GSACLTGNSQ SGLAAWYLSH LIHKDGWGRM GFFGYDLQDQ CGPTNVFSYQ GDEGSPLELR
     GANYPNYAMN VGHQGEYAGI SSAAHAGRFD AYACNPLIKV CFANPALIFT WDDIRKGYGM
     GGAREFRAAG ERSLVMPAV
//
DBGET integrated database retrieval system