ID G7X568_ASPKW Unreviewed; 615 AA.
AC G7X568;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Serine/threonine-protein kinase ATG1 {ECO:0000256|ARBA:ARBA00018572};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE AltName: Full=Serine/threonine-protein kinase atg1 {ECO:0000256|ARBA:ARBA00019599};
GN ORFNames=AKAW_00346 {ECO:0000313|EMBL:GAA82231.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA82231.1};
RN [1] {ECO:0000313|EMBL:GAA82231.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA82231.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; DF126447; GAA82231.1; -; Genomic_DNA.
DR AlphaFoldDB; G7X568; -.
DR STRING; 1033177.G7X568; -.
DR VEuPathDB; FungiDB:AKAW_00346; -.
DR eggNOG; KOG0615; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR InParanoid; G7X568; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR045269; Atg1-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24348:SF22; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR PANTHER; PTHR24348; SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT DOMAIN 1..284
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 383..415
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 491..523
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 524..558
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 559..591
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 290..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 615 AA; 68841 MW; A557240BCD429890 CRC64;
MDEIAKSFRL NVTAVSESCN REILQHSSDD AGKDNGRTVV IWNRKDDLTK DVYLEKSQSG
QLRVVKQVTT TDKSINYSKP LFVQFIGWFP YKNHVCLAME YCPYGDLKSY YTRPIPEAEA
RNICTQLLDG LEVLHSLGIV HRDIKPENVL VFQKTPMKVK ITDFGVSKRA LEGQTEHRTA
CGTMGFMAPE VLHLVDDTKE DSTFTSAVDI WSLGCLLYYI LTKQTPFSKY ELLRDYAKGR
TAFPDGHLKE YHVSRQGRKF IERLLDPLPE ARPSASADLT SYWTIPDTGE ESIYPEPPSP
GDADPSGFSR AFGDSTQPPI NDAQWIGFPD VPFELGPLSD NDMDYFSTEL WNFVKSARTF
DRASTVKLQA LLTTHASPSR LHNGYTALHI ASESAPAEWV KLLLEYGADA HIRTEPGRET
SLHLSTSKGD LEDFTKKSEL LLAIRAVREG INAQNSNGDT VLHLAIARFG TVSAIQPLLD
AEASTNIKGR QGRTPLLYAL YLEQEAVATE LLDRDSDPHA LDNGGFSALH YAIASRTISI
QFIKRLLDAG VDVNWKNEDD RTPLYLAAQK SKQEVMRLLL DHGAIPELGN PRLDIRVNQV
QFATKIGLKS LWPFS
//
