ID   G7XF62_ASPKW            Unreviewed;      1199 AA.
AC   G7XF62;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Rho guanyl nucleotide exchange factor {ECO:0000313|EMBL:GAA85209.1};
GN   ORFNames=AKAW_03323 {ECO:0000313|EMBL:GAA85209.1};
OS   Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS   awamori var. kawachi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA85209.1};
RN   [1] {ECO:0000313|EMBL:GAA85209.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA85209.1};
RX   PubMed=22045919; DOI=10.1128/EC.05224-11;
RA   Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA   Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT   "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT   for brewing the Japanese distilled spirit shochu.";
RL   Eukaryot. Cell 10:1586-1587(2011).
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DR   EMBL; DF126453; GAA85209.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7XF62; -.
DR   STRING; 1033177.G7XF62; -.
DR   VEuPathDB; FungiDB:AKAW_03323; -.
DR   eggNOG; KOG4305; Eukaryota.
DR   InParanoid; G7XF62; -.
DR   Proteomes; UP000006812; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04435; DEP_fRom2; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041675; PH_5.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF15405; PH_5; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00036; CNH; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
FT   DOMAIN          331..406
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          501..693
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          877..1175
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          1..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          454..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..88
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..192
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1199 AA;  135493 MW;  7F79361DE109F1CF CRC64;
     MADLGGQQGR NYRPYGHPSA FQRDAAFSEI FGGAPGRSQT MTSQTPQFSQ DRAHTMSSHV
     PHPQMQRGPP PPARQMQNGY PPGPPNGYYQ PYGGSAATMT SQHPSQNPPR PYPGRSAYPQ
     PQRLDSRPNH GPQYPDAKGY ARPVPHPALN SDAYRSRSMA RLGGPPIYQP PSSGFNHTSA
     TYSRQQPYNA GAAPMTPQGR VVPERNQNER SMSLTTYSTD RDHAHTTQTG RVIPPRRQPS
     GPSPPPEASS YPADVINAYD VNGKSRPPSD GSMNSRTMSM ASTVVPDRTM SMQSQIAPKP
     SNTSTLVQSN SRRSKVPLVY PALLSRVADV FRERITLAER QKNGLSYQNA FSGAEAVDLI
     AYIIKTMDRN LALLLGRALD AQKFFHDVTY DHRLRDAPGE LYQFKETMGE EAPSSEVNGV
     FTLLTECYSP TCTRDSLCYS IACPRRLEQQ ARLNLKPQPG LRSSASKGSL HGDDDDNDNQ
     KLWINMVPKE ISDGIDDREK KRQEIIFEIM YTERDFVKDL EYLRDFWMRP LRSAGNANLS
     PIPEHRREKF IRTVFGNCLE VLKVNGGLCE ALNARQKENH VVKTVGDIFL QHVPRFDPFI
     KYGANQLYGK YEFEKEKASN PAFARFVEET ERLKESRKLE LNGYLTKPTT RLARYPLLLE
     QVAKNTADDN PDKQDIPKAI KLIKDFLSRV NAESGRAENH FNLVQLNSAL KFPPGEYVDL
     KLTEENRQML TKMAFKKTPT DSSEVTAYLF DHAVLLVRIK IVNKREEYRV YRKPIPLELL
     VIAQMDEVIP RVGVAKRPSS SLLSNKAAAN PPTTKDGLPI TFRHLGKGGY EQTLYATSPT
     QRRKFIEMVE EQQRKLRERN SNFYNKTVLC EKFFTSVNRV NCLVPVDGGR KLVYGTDSGI
     YLSERWPKDK SARPRRVLDV SQVTQMDTLE EYQLLLVLSN KTLSSYPMEA LEISESQNTV
     AKRPKKIQGH ANFFKAGIGL GRHLVCSVKT SALSTTIKVY EPMDNLAKGK KKSAVSKMFQ
     SGQDSLKLFK EFYIPAESSS IHFLRSTLCV GCARGFEVVS LETTETQSLL DQADTSLDFV
     ARKENVKPIH IERMNGEFLL NYSDFSFFVN RNGWRARPDW KISWEGNPNA FALSYPYILA
     FEPNFIEIRH IETSELVHIM TGKNIRMLHS STREILYAYE DESGEDVVAS LDFWNKPQH
//