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Database: UniProt
Entry: G7XFS8_ASPKW
LinkDB: G7XFS8_ASPKW
Original site: G7XFS8_ASPKW 
ID   G7XFS8_ASPKW            Unreviewed;      1675 AA.
AC   G7XFS8;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=AKAW_03901 {ECO:0000313|EMBL:GAA85787.1};
OS   Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS   awamori var. kawachi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA85787.1};
RN   [1] {ECO:0000313|EMBL:GAA85787.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA85787.1};
RX   PubMed=22045919; DOI=10.1128/EC.05224-11;
RA   Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA   Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT   "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT   for brewing the Japanese distilled spirit shochu.";
RL   Eukaryot. Cell 10:1586-1587(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966,
CC         ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; DF126454; GAA85787.1; -; Genomic_DNA.
DR   STRING; 1033177.G7XFS8; -.
DR   VEuPathDB; FungiDB:AKAW_03901; -.
DR   eggNOG; KOG0968; Eukaryota.
DR   InParanoid; G7XFS8; -.
DR   Proteomes; UP000006812; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   CDD; cd05778; DNA_polB_zeta_exo; 1.
DR   CDD; cd05534; POLBc_zeta; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR   Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR   PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU000442}; Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN          823..1003
FT                   /note="DNA-directed DNA polymerase family B exonuclease"
FT                   /evidence="ECO:0000259|Pfam:PF03104"
FT   DOMAIN          1074..1520
FT                   /note="DNA-directed DNA polymerase family B
FT                   multifunctional"
FT                   /evidence="ECO:0000259|Pfam:PF00136"
FT   DOMAIN          1572..1644
FT                   /note="C4-type zinc-finger of DNA polymerase delta"
FT                   /evidence="ECO:0000259|Pfam:PF14260"
FT   REGION          464..625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        470..509
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..524
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..554
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        603..625
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1675 AA;  191098 MW;  9EC3E5F7CDC357FD CRC64;
     MEPFQVRLNC VDHYQATPSE LDPPLPYRDG AAGKNDRSKV PVIRIFGATE TGQKVCVHVH
     GAFPYLYVEY DGDLETEKVS SAIRSLRLSI DHALAVSYNR NENAKKIAFV AHITLVKGVP
     FYGYHVGYKF YFKIYLMNPI YMTRLADLLL QGAVLKRPLQ PYESHLQFVP QWMCDYSLYG
     CAYLKCSKVK FRSPVPEYFE LTDLSHRWHD RSVQPDDLLD DSLFPKQSHC PLEVDICVQD
     ILNRSEISER PIHQDFTELF KQMTSDERLV PSMAGLWQDE TRRRKKRLGL EPGSSPFDPN
     ELVSLSVNPR DTFRGGWIHE EEYREMAAQT VNEEKQQNGG GDVTFDDLLS QKPFAQDVKT
     AMQSVEDFYP DKNNFDKYQQ QPVEPDTAAN AEVNVDESAA WPVVSDDDLY LSDDDIFDVL
     PGEDNDREAA SALDENQAGD ILDLTQDEPE YSVDDLNAYE MSATRKAGSD EMVGRTESRE
     PSHNNMRKRK RFFDDTPSQM LDRPRKSRIA EVQVNSTTPK IEDTANTLDA DAVVRGKSSQ
     KKPSQSTVRS KRPEQSGRLN FPVVKDPNDP MTILRFSQDG APSSKELREL EKDLASSGPE
     VISKDTRAEN SSSQPQSSVT VTSPDAGIDP QIFEIASGFY AAFNVPMNAR ICFLRNFSPS
     TSEVASTPHS YDYPSVIYQK AHYSDESDVP DRARDYAGRE FRLEGNGIHY LPDFDPSGRS
     MAMLGEYTPP RDKNEQEVVD QQLREFSTSR FWEFGPVPPS RSEVIEWFEK CQAEEKADAA
     QPQAPKQVQM KANVLSQIEG PTQKNGYGFK YSQKGRSTSV EHQTQYMSIM SLEVHVNTRG
     VLLPNPEEDE ITCVFWCLQS EDEDLDANGT VPGVHVGMIS QSEHDRPDTK ASKALRIDWE
     HETSELDLIN RVVDIVRWHD PDIITGYEVH NSSWGYLIER ARKKYDFDIC DELSRVKSQA
     HGRFGKDADR WGFNHTSSIR VTGRHMINIW RAMRGELNLL QYTQENVAFH LLHRRVPHYS
     FQDLTDWYRS GKPRNILKVV EYFVSRVQMD LEILESNELI PRTSEQARLL GIDFFSVFSR
     GSQFKVESLM FRIAKPENFI LVSPSRKQVG QQNALECLPL VMEPQSDFYT SPLVVLDFQS
     LYPSIMIAYN YCYSTFLGRA HQWRGRNKMG FTDYKRQPRI LELLQDKINI APNGMIYAKP
     EVRKSLLARM LAEILETRVM VKNGMKLDKD DKALQRLLNN RQLALKLIAN VTYGYTSASF
     SGRMPCSEIA DSIVQSGRET LEKAIAFIHS VERWGAEVVY GDTDSLFVYL KGRTRDEAFT
     IGEEIAKAVT SINPHPVKLK FEKVYHPCVL LAKKRYVGFK YEHRDQKEPE FDAKGIETVR
     RDGTPAEQKI EEKALKLLFR TADLSQVKRY FQSQCTKIMQ GRVSVQDFCF AREVRLGTYS
     DRGLPPPGAL ISTKKMIADP RSEPQYGERV PYVVVTGAPG ARLIDRCVPP ETLLHDPHLD
     LDADYYITKN LIPPLERIFN LVGANVRQWY DEMPKVQRVR RVEGAMIRGP GGGGGGGGGR
     RTLESYMRAS TCIVCKTKLR DTDTPLCGNC SRQPHLAMFE LVSRQRAAEK RVVDLQRICR
     SCMGVTFGDE VKCDSKDCPV FYSRTRDEAN WRYTKAVLDP VVGLLRDRCE KELEW
//
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